ID   MON1_ASPFU              Reviewed;         621 AA.
AC   Q4WHL1;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Vacuolar fusion protein mon1;
GN   Name=mon1; ORFNames=AFUA_2G05010;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL87594.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000008; EAL87594.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_749632.1; XM_744539.1.
DR   AlphaFoldDB; Q4WHL1; -.
DR   SMR; Q4WHL1; -.
DR   STRING; 746128.CADAFUBP00002150; -.
DR   PRIDE; Q4WHL1; -.
DR   GeneID; 3507032; -.
DR   KEGG; afm:AFUA_2G05010; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   HOGENOM; CLU_014574_4_0_1; -.
DR   InParanoid; Q4WHL1; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..621
FT                   /note="Vacuolar fusion protein mon1"
FT                   /id="PRO_0000278853"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   621 AA;  67859 MW;  DCFDBF405764B6A4 CRC64;
     MNPNALEQPQ VAPGDDGAGG NNYGTQENSA KEPSKTGSDD SSARLEERPP PLPPRPNTLS
     LLDEGFISPR STRQSSSSSL QAKATTAVSI PDISLLQLND GGKENHPTRG PFGSLRAKAS
     LTQLTASKGS DAGDSASIRS TAPNTELGEA ENVFSDFLAQ ESGDVQQDSS GLLQFPEFRT
     DDVEDDFTSE FEPIGELDDD GRNEELLLER WKSKRKHYLI LSAAGKPIWT RHGDGGLISG
     YIGVILTIIS FYEDANDRLT SFCAGDTKFV IVTKGPLYLV AISRLLESDT QLKLQLEALY
     MQILSTLTLP SLTHLFSVRP STDLKRPLQG SETLLSTLAD SFTKGSPSTF LSALECLKIR
     KSHRQAINNA LLKTKVSSLL YGLVVAGGRL VSVVRPKKHS LHPGDLQLLF NMIFEAEGIK
     AGGGESWIPV CLPGFNSSGY LYMYVSFLDL RENSGTSASE TTTEQSVAII LISPNKEGFF
     EMQEMRNSLV EQLEKNNSIN IIKEAIDGGR PTTTDIVPGT VLHHFLYKSR ANVQFTMSSY
     EPEFTSISRR RSIHAKHAHV KVHHCISQSA SSFAWVTPIF ELYCVASPNA NRNALAQSAS
     KVVQWVQREE ERLFIIGGAV F