ID   MON1_CANAL              Reviewed;         565 AA.
AC   Q5A723; A0A1D8PSL7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; OrderedLocusNames=CAALFM_CR03960CA; ORFNames=CaO19.8109;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31134.1; -; Genomic_DNA.
DR   RefSeq; XP_717342.2; XM_712249.2.
DR   AlphaFoldDB; Q5A723; -.
DR   SMR; Q5A723; -.
DR   STRING; 237561.Q5A723; -.
DR   GeneID; 3640963; -.
DR   KEGG; cal:CAALFM_CR03960CA; -.
DR   CGD; CAL0000177089; orf19.8109.
DR   VEuPathDB; FungiDB:CR_03960C_A; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   HOGENOM; CLU_025637_0_0_1; -.
DR   InParanoid; Q5A723; -.
DR   OMA; NDHGFLY; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..565
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000278856"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  64521 MW;  0DB9DBEABB1513FE CRC64;
     MSFPKTLNVP DKSSLLVPQT TKASATGPTT AVSYETASSE IRSIRESPYL PSSPVDSQQF
     DGRSIISTSG MSEYIADLND LPSIRHDINP TSIKTGGTGS RSFKFSNCFQ TLDSELSNMD
     FFTKYISISK GDDKAQFNNK LKHFFIFSSA GKPIYSMNGS DDIVIGYMGI LTTIVSSFQE
     NFNQELQVLE LGQGLKIVAV NKSPIILISI SKLSFETVES VHLQLDTLYC YLIGILSKSV
     IDKHFNNRLN YDLRRILSPL DFENLDELCL NLTYGIPNTS DRTQDSTFGL YTSQVLLPLS
     RESVKIRHTL RSKLNSIVNT NNEDVLFTIL LSGNGKILNY LHPKQHNLPN KDLNMLLFII
     HSLLKNQSQQ DEDLWLPLCM PTFNDHGFLY VFVRQWQDLV LMLISGSKNS FDALKLSANE
     ICTKLNNKQE LAVKLINELS IPLSIEVPFV FKHFIYKDIR LNQFVMSELP THEFSSFQFL
     KCYNELKVSQ AKIIKHDNNL NYKKLTYLQD RDITGFMLMD KYYEFYCIIE RSSEQETITS
     KKLIQISSQI IRWCKKNHAR LFVTI