ID   MON1_CHAGB              Reviewed;         656 AA.
AC   Q2HFQ4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; ORFNames=CHGG_00950;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; CH408029; EAQ92715.1; -; Genomic_DNA.
DR   RefSeq; XP_001220171.1; XM_001220170.1.
DR   AlphaFoldDB; Q2HFQ4; -.
DR   SMR; Q2HFQ4; -.
DR   STRING; 38033.XP_001220171.1; -.
DR   EnsemblFungi; EAQ92715; EAQ92715; CHGG_00950.
DR   GeneID; 4387539; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   HOGENOM; CLU_014574_5_0_1; -.
DR   InParanoid; Q2HFQ4; -.
DR   OMA; TNSTCEY; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..656
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000278858"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..38
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  71214 MW;  18736B74D1984D7E CRC64;
     MARETEVESS HDGPPKVTET SPSPSPSPPP PPLPPRQMIS SDSPAQVAPA QAKPTTAVSS
     IDISTVSFPD GSRGTFSTSA PRVGFTPHTN ASGYGTPGRD ATGGDLADSM SVMSFAPTLR
     PHGDLASLVA DGLNKKSRAW NMLRSQSETV QPFESIELGA PGSLAGFERE FDEIPDDKTD
     DIRMAIWKSK MKHYMILSSA GKPIYSRHGD LGLVNSYMGV VQTIISFYEG ANNPLLGFTA
     GNARFVIAIE GPLYFVAISR LNESDAQLRS QLEALYMQIL STLTLPTLKS IFVHRPSTDL
     RKPLEGTESL LSSLADSFTR GSPSTLLGAL ECLKLRKSQR HAINNVFLKN RSEKLLYGLV
     VAGGKLVSVI RPRKHSLHPS DLQLIFNMLF ESGGIKSGGG ESWIPLCLPA FNNRGYLYMY
     VSFFDGNADP AFSAESTAED TPESSTDTNT TNTTEKEDEI ALILISPDKE SFYDLKEMRD
     KLAAQLTKTG HLSLIRSAAR ERRPQIQTIA PGAQIAHFLY KSRANVQFCM SALEPANPNP
     TPGTSSTTPT TVATTATVAS TSTSTLEPEK MLTRRRLMTL YHELHASMHA KHAHLKVLHA
     VSEDAASLAW ITPVFEFYCV AGPNAPRAAM AQGANRVIQW AKREEERLFI IGGGVF