ID   MON1_COCIM              Reviewed;         640 AA.
AC   Q1E8Q5; J3KII2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; ORFNames=CIMG_01058;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS35704.2; -; Genomic_DNA.
DR   RefSeq; XP_001247287.2; XM_001247286.2.
DR   AlphaFoldDB; Q1E8Q5; -.
DR   SMR; Q1E8Q5; -.
DR   STRING; 246410.Q1E8Q5; -.
DR   EnsemblFungi; EAS35704; EAS35704; CIMG_01058.
DR   GeneID; 4567519; -.
DR   KEGG; cim:CIMG_01058; -.
DR   VEuPathDB; FungiDB:CIMG_01058; -.
DR   InParanoid; Q1E8Q5; -.
DR   OMA; TNSTCEY; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..640
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000278859"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  70576 MW;  4056844EB7711327 CRC64;
     MDTGKEKDRL DTENPSLIAG NTKQQATSQS SESKTKLAVE KDTDPPLPSR PTTRSATGRS
     KAAPDTVLSI RHASKNVLQS KPTTAVSLQD INSQTFQEGS NDIYSLLGAR SGNEEAIKSK
     CSLSRPGSGK ESDAADSASI KSVIPGEGTP VEVGSIFGDF TGAGQPQPLW DTKRKQVNIF
     DRSEPGLEDD DLSLDFESEF DCVEDIAADD NGDKILEEWR QKRKHYFILS AAGKPIYTRH
     GDDGLISPYI AIIQTIISFH QESSNPLKSF SAGRTKIVIL SQGPLHLVAI SRLLESDSQL
     RNQLDALYMQ ILSTLTLPAL QHIFAVRPST DLRRPLQGTE SLLSSLADSF TKGSPSTLVS
     ALECLKLRKS YRQQINSILL KSRVEPLLYG LVVAGGRLVS VIRPKKHSLH PGDLQLIFNM
     IFEADGVKAG GGESWIPICL PGFNSRGYLY MYVSFLDLHD HLPEDDKDIN KDDAVAIILI
     SADKESFFVL REMRDSVVQE LEKSNSKNII RAAIEKGRPA TTDIVPGTVL RHFLYKSKSN
     VQFTMSSYSP DFTTLVARRR LLSTYHGLHS SVHSKNTHVK VQHCASRFMN SLAWVTPNFE
     LYCVASPNSN RNALSQSANK IAQWVQQEDE RVFIIGGAVF