ID   MON1_CRYNB              Reviewed;         620 AA.
AC   P0CO83; Q55TC3; Q5KJ15;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; OrderedLocusNames=CNBD5300;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; AAEY01000021; EAL21154.1; -; Genomic_DNA.
DR   RefSeq; XP_775801.1; XM_770708.1.
DR   AlphaFoldDB; P0CO83; -.
DR   SMR; P0CO83; -.
DR   EnsemblFungi; EAL21154; EAL21154; CNBD5300.
DR   GeneID; 4935919; -.
DR   KEGG; cnb:CNBD5300; -.
DR   VEuPathDB; FungiDB:CNBD5300; -.
DR   HOGENOM; CLU_014574_2_0_1; -.
DR   Proteomes; UP000001435; Chromosome 4.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Transport; Vacuole.
FT   CHAIN           1..620
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000410148"
FT   REGION          1..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  68671 MW;  7EE9F2470388D9B5 CRC64;
     MTSESEPNTS LPFSPIQQTL PATPSRSTSQ VSMVSAEALL SHSSPTKQLT PSHRSSLPSA
     LPYNTLLNAP AGSPALRARA STASSSRAPS VLDDARVEHN DSETQVLEIT PPMDNYELDG
     GSDHTSLPSD ASSIKGKEKQ RSNDRNEIET VGAGGEMALP SGDARKGLKE LVRRSTTADK
     GYGGHDHRRL SEKLSQTDEN LQILITQSDK MSYSPRLYYV LTNAGKPVFC SHTRPSEDDV
     TNLMGVAQAL ISIFADDDDR LRYIIKGNHR VAFLLKAPLY LFCVSDWGEP EHVLRLQLEY
     IHLQILSVVS STQLLRLFQR RSNADLSTLL EGTEPFLSNL IDCSQYDFSF LTSTLQPLRM
     APALRDTSAA ALMPPSKFKD LLYVLLIAGG HIVTVLRPRK HSIHPSDLHL LLNTIASSSA
     LRTTETWLPI CFPKFNPSGF VHAYISYVLE DVGLVFVSAD REAFEDLRVW KDMVLEKLEQ
     DKTLSRIQEA IPLHPYTISS VGCPGLRHFI YKSRQHVQIT QPIWEAPYED GSTNQKRLVT
     TYQKLHDAVH AKSGQASALK LVYISTEHEA CLVWATKPFE LYITVSPQLS KSAVVAAANN
     VAKWVLAEEG RIFLKDAPVF