ID   MON1_CRYNJ              Reviewed;         619 AA.
AC   P0CO82; Q55TC3; Q5KJ15;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; OrderedLocusNames=CND01000;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; AE017344; AAW43007.1; -; Genomic_DNA.
DR   RefSeq; XP_570314.1; XM_570314.1.
DR   AlphaFoldDB; P0CO82; -.
DR   SMR; P0CO82; -.
DR   STRING; 5207.AAW43007; -.
DR   PaxDb; P0CO82; -.
DR   EnsemblFungi; AAW43007; AAW43007; CND01000.
DR   GeneID; 3256977; -.
DR   KEGG; cne:CND01000; -.
DR   VEuPathDB; FungiDB:CND01000; -.
DR   eggNOG; KOG0997; Eukaryota.
DR   HOGENOM; CLU_014574_2_0_1; -.
DR   InParanoid; P0CO82; -.
DR   OMA; TNSTCEY; -.
DR   OrthoDB; 829786at2759; -.
DR   Proteomes; UP000002149; Chromosome 4.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..619
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000278860"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  68569 MW;  9741FB4FA0FC38D7 CRC64;
     MTSESEPNTS LPFSPIQQTL PATPSRSTSQ VSMVSAEALL SHSSPTKQLT PSHRSSLPSA
     LPYNTLLNAP AGSPALRARA STASSSRAPS VLDDARVEHN DSETQVLEIT PPMDNYELDG
     GSDHTSLPSD ASSIKGKEKQ RSNDRNEIET VGAGGEMALP SGDARKGLKE LVRRSTTADK
     GYGGHDHRRL SEKLSQNENL QILITQSDKM SYSPRLYYVL TNAGKPVFCS HTRPSEDDVT
     NLMGVAQALI SIFADDDDRL RYIIKGNHRV AFLLKAPLYL FCVSDWGEPE HVLRLQLEYI
     HLQILSVVSS TQLLRLFQRR SNADLSTLLE GTEPFLSNLI DCSQYDFSFL TSTLQPLRMA
     PALRDTSAAA LMPPSKFKDL LYVLLIAGGH IVTVLRPRKH SIHPSDLHLL LNTIASSSAL
     RTTETWLPIC FPKFNPSGFV HAYISYVLED VGLVFVSADR EAFEDLRVWK DMVLEKLEQD
     KTLSRIQEAI PLHPYTISSV GCPGLRHFIY KSRQHVQITQ PIWEAPYEDG STNQKRLVTT
     YQKLHDAVHA KSGQASALKL VYISTEHEAC LVWATKPFEL YITVSPQLSK SAVVAAANNV
     AKWVLAEEGR IFLKDAPVF