MON1_EMENI
ID MON1_EMENI Reviewed; 614 AA.
AC Q5BBI7; C8VLX1;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Vacuolar fusion protein mon1;
GN Name=mon1; ORFNames=AN2093;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC endocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF86164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000032; EAA64925.1; -; Genomic_DNA.
DR EMBL; BN001307; CBF86164.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_659697.1; XM_654605.1.
DR AlphaFoldDB; Q5BBI7; -.
DR SMR; Q5BBI7; -.
DR STRING; 162425.CADANIAP00008765; -.
DR EnsemblFungi; EAA64925; EAA64925; AN2093.2.
DR GeneID; 2874637; -.
DR KEGG; ani:AN2093.2; -.
DR eggNOG; KOG0997; Eukaryota.
DR HOGENOM; CLU_014574_5_0_1; -.
DR InParanoid; Q5BBI7; -.
DR OrthoDB; 829786at2759; -.
DR Proteomes; UP000000560; Chromosome VII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport; Vacuole.
FT CHAIN 1..614
FT /note="Vacuolar fusion protein mon1"
FT /id="PRO_0000278861"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 66632 MW; 536FFFD2C9CD5559 CRC64;
MDTKDSNSSQ ALAIDGGAQT RPTDDHASLT KRLTQPRSDR SQSPEGRPPP LPPRPETLIL
LEDGGAAPGT PRPNVSAVHP GLQSRATTAV SLAEISQNDR GKDALAVRSF PGTVRAKASL
SHLATPKDGS DAGDSASVTS YVPYSESGDV ENIFGSLASS EVGIAQEEST GLMQFPEFQA
DDVEDDFASE LEPVGEIGEG GENEGTVLAY GSTTAETDQL IDLVLEKWKA KRKHYIILSA
AGKPIWTRHG DGGLISTYVG IIQTIISSYE DSNDRLNGFT AGDTKFTVVA KGPLYLVAIS
RILESDTQLK LQLEALYMQI LSTLTLPALT HLFSVRPSTD LKRPLQGSET LLSTLADSFT
KGSPSTLLSA LECLKIRKSH RQTINNTLLK TKVSKLLYGL VVAGGRLVSV VRPKKHSLHP
GDLQLLFNMI FEAEAVKAGG GESWIPVCLP GFNSSGYLYI FFELQAMKNA LVEKLEENGS
INNIKEAIDK GRPSTTDIVP GSVLHHFVYK SRVNVQFIMS AYDPEFSTIT RRRRLISTYN
NLHASVHAKH THVKVHHCVT QSSSSFAWIT PVFELYCVAG PHANRNALAQ SASKVVQWVQ
KEEERLFIIS GAVF
