MON1_NEUCR
ID MON1_NEUCR Reviewed; 678 AA.
AC Q870Q4;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Vacuolar fusion protein mon1;
DE AltName: Full=Autophagy-related protein 13;
GN Name=apg-13; Synonyms=mon1; ORFNames=B1D14.310, NCU09220;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC endocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR EMBL; BX295539; CAD79674.1; -; Genomic_DNA.
DR EMBL; CM002236; EAA29928.3; -; Genomic_DNA.
DR RefSeq; XP_959164.3; XM_954071.3.
DR AlphaFoldDB; Q870Q4; -.
DR SMR; Q870Q4; -.
DR STRING; 5141.EFNCRP00000008880; -.
DR EnsemblFungi; EAA29928; EAA29928; NCU09220.
DR GeneID; 3875286; -.
DR KEGG; ncr:NCU09220; -.
DR VEuPathDB; FungiDB:NCU09220; -.
DR HOGENOM; CLU_014574_5_0_1; -.
DR InParanoid; Q870Q4; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport; Vacuole.
FT CHAIN 1..678
FT /note="Vacuolar fusion protein mon1"
FT /id="PRO_0000278864"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 73728 MW; 6E9FF5FD686C2D60 CRC64;
MDRDTEAGSN DGTNDNNDTT IPPHTPESNI EAVDHVPPVP RRPSPKLSDD GASGALHVAA
ASRPTTQVST IDISTLSFPD GSRGTFSTSA TSATSATSAT RSVASPQSSA SGYTSPRTDL
VETVSVASYP ATLRPPGDLA DLVTGEFNRR SRAWSMLRTQ SSSVQPFEAS RTGACDSLTG
FEKEFDNIPE LGEKGITDEQ RLSLWKSKMK HYMILSSAGK PIWSRHGDTS LINSYMGVVQ
TIISFYEGAK DPLLGFTAGN ARFVISTQGP LYFVAISRLG ESDAQLRSQL DALYMQILST
LTLPTLKNIF VHRPSTDLRK PLEGTESLLS SLADSFTKGS PSALLGALEC LRLRKSHRAT
INNAFLKCRS DKLLYGLIVA GGKLVSVIRP RKHSLHPSDL QLIFNMLFES GGIRAGGGEN
WVPLCLPAFN NRGYLYMYVS FFDSVETAEE NNSNNTNNPE QPPQPPPPKP VTSPDEEIAI
ILISADKESF FELKSMRDKL ALQLAKNGSL ALIQSAARQG RPRIETILNT KPLSKEAGQG
QGQGQLSHFL YKSRANVQFC QSSLSPAFET SSPPLPSSSP SENGSSQKTT EKLVSRRRLM
TLYHHLHASI HAKHSHLKVL HLVSEDAASL AWITPVFEFY CVAGPNMSSG IMTQCANKVV
QWAKREEERL FIIGGGVF
