MON1_ORYSJ
ID MON1_ORYSJ Reviewed; 567 AA.
AC Q5JL08; B9EX08; Q0JFK1;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Vacuolar fusion protein MON1 homolog {ECO:0000305};
GN Name=MON1 {ECO:0000305};
GN OrderedLocusNames=Os01g0976000 {ECO:0000312|EMBL:BAF07477.2},
GN LOC_Os01g74460 {ECO:0000305};
GN ORFNames=P0020E09.1 {ECO:0000312|EMBL:BAD87032.1},
GN P0459B04.31 {ECO:0000312|EMBL:BAD87849.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Plays an important role in membrane trafficking through the
CC secretory apparatus. In complex with CCZ1, acts as a guanine exchange
CC factor (GEF) for Rab7 protein family. Promotes the exchange of GDP to
CC GTP, converting it from an inactive GDP-bound form into an active GTP-
CC bound form. The active form is involved in protein trafficking from
CC prevacuolar compartments (PVCs) to vacuoles. May serve as a linker
CC between Rab5 and Rab7 protein families in PVCs and mediate PVC
CC maturation. {ECO:0000250|UniProtKB:Q9SKN1}.
CC -!- SUBUNIT: Interacts with CCZ1A, CCZ1B and RABF2B.
CC {ECO:0000250|UniProtKB:Q9SKN1}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q9SKN1}.
CC Prevacuolar compartment {ECO:0000250|UniProtKB:Q9SKN1}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR EMBL; AP003228; BAD87032.1; -; Genomic_DNA.
DR EMBL; AP003627; BAD87849.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF07477.2; -; Genomic_DNA.
DR EMBL; AP014957; BAS76467.1; -; Genomic_DNA.
DR EMBL; CM000138; EEE56104.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5JL08; -.
DR SMR; Q5JL08; -.
DR STRING; 4530.OS01T0976000-01; -.
DR PaxDb; Q5JL08; -.
DR PRIDE; Q5JL08; -.
DR EnsemblPlants; Os01t0976000-01; Os01t0976000-01; Os01g0976000.
DR Gramene; Os01t0976000-01; Os01t0976000-01; Os01g0976000.
DR eggNOG; KOG0997; Eukaryota.
DR HOGENOM; CLU_014574_3_1_1; -.
DR InParanoid; Q5JL08; -.
DR OMA; TNSTCEY; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:EnsemblPlants.
DR GO; GO:0099402; P:plant organ development; IEA:EnsemblPlants.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:EnsemblPlants.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Endosome; Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..567
FT /note="Vacuolar fusion protein MON1 homolog"
FT /id="PRO_0000438480"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6..22
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 457
FT /note="F -> L (in Ref. 5; EEE56104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 567 AA; 63751 MW; 1AB0B30FE1BE148B CRC64;
MDMDPPTNNP SPPGPPDSPP PEKRLASLSL RTSHLPPDFE IHDDYDDDDD EGYLTAVSRV
GSISTSASAW KDDLEDADVA PPSPSSSGYA AERGTSLASS AAANDDPQPQ PDDDDWPRDK
KHLHEDDTSA SWRKRKKHFF ILSNSGKPIY SRYGDEHKLA GFSATLQAII SFVENSGDHI
KFVRAAKHQI VFLVKGPIYL VCISCTEESY EGLRGQLELM YGQMLLILTK SVNRCFEKNP
KFDMAPLLGG TDAVFLSLIH AFSWNPATFL HAYTCLPLAQ STRQAASAVL QDIADSGVLF
ALLMCEHKVI SLVGAQKATL HPDDIFLLSN FILSSESFRT SESFSPICLP RYNSMAFLYA
YVHFFDENTY LTLLTARSDA FYDLKDSRSR IQNVLLKANV LVEVQRSLRE SALRIEDLPA
DPSSQSVSPP PQFSQDLHFQ LLSSEMAIGG PAGLWHFIYK SIYLDQYVSS EFPLIISNPK
QQKRLYKAYQ KLYASMHDKA TGPHKTQFRR DEDYVLFCWI TQDFELYAAF NPLADKSQAI
KVCNRVCQWI RDLENEIFVY GESTLSW
