MON1_SCHPO
ID MON1_SCHPO Reviewed; 513 AA.
AC Q10150;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Vacuolar fusion protein mon1;
GN Name=mon1; ORFNames=SPAC1D4.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC endocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAA93212.1; -; Genomic_DNA.
DR PIR; T38044; T38044.
DR RefSeq; NP_593016.1; NM_001018415.2.
DR AlphaFoldDB; Q10150; -.
DR SMR; Q10150; -.
DR BioGRID; 278920; 78.
DR STRING; 4896.SPAC1D4.03c.1; -.
DR MaxQB; Q10150; -.
DR PaxDb; Q10150; -.
DR EnsemblFungi; SPAC1D4.03c.1; SPAC1D4.03c.1:pep; SPAC1D4.03c.
DR GeneID; 2542459; -.
DR KEGG; spo:SPAC1D4.03c; -.
DR PomBase; SPAC1D4.03c; -.
DR VEuPathDB; FungiDB:SPAC1D4.03c; -.
DR eggNOG; KOG0997; Eukaryota.
DR HOGENOM; CLU_014574_3_0_1; -.
DR InParanoid; Q10150; -.
DR OMA; TKTCAIT; -.
DR PhylomeDB; Q10150; -.
DR PRO; PR:Q10150; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000329; C:fungal-type vacuole membrane; ISO:PomBase.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006914; P:autophagy; ISO:PomBase.
DR GO; GO:0006623; P:protein targeting to vacuole; ISO:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport; Vacuole.
FT CHAIN 1..513
FT /note="Vacuolar fusion protein mon1"
FT /id="PRO_0000116468"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 58003 MW; 17458C42CD5BB10A CRC64;
MEPTSEHSSI KEEVENDNVH RSHESECGSL LLNPGNVLMA APSVSEDDQE VSRSTPELRS
HVENVEQLLS DILHDNSSPL NVSTSVSSSS NNTAVDEIIK LLSLISFDLA KQKRTYLIFS
SSGKPVFSNI VDDSIEPSTV GALQAIISSF EVSKEELTSF STFSNVIVVL SKNPLYLVGV
SPSTTLSAAY LLSELNLLYC QILTGVTAKA MQLTLNSRPN FDLRRLIGSN EQFLKELCDQ
LNDYELVPTL NAISPLPLRS SFRDQLSQLL LRETPKSLLF TFIAIRGRLV CMVKAKKLLL
HANDLYLLFL SLFRTQSFND SMEHWVPVCF PTLNPDAYIY IYSYFLCKDT VLIMGSSESG
VFFEMQSVKC KVAQEIQDHG WLKKLIYCEE MDRTTPRNPG SPCISHYLFY SKKYSQFYTP
GYSFSTPNFN TRTLYAIYAS LHDQAFHKKN SFSINMTVHE SLLLFTWSTA SFDFHCIANA
TTSSQLLIAN VNKILRWIRR EENRLFIQTN LSF
