MON1_USTMA
ID MON1_USTMA Reviewed; 887 AA.
AC Q4PA36; A0A0D1CR66;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Vacuolar fusion protein MON1;
GN Name=MON1; ORFNames=UMAG_03027;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC endocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC compartment membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR EMBL; CM003146; KIS69048.1; -; Genomic_DNA.
DR RefSeq; XP_011389404.1; XM_011391102.1.
DR AlphaFoldDB; Q4PA36; -.
DR STRING; 5270.UM03027P0; -.
DR EnsemblFungi; KIS69048; KIS69048; UMAG_03027.
DR GeneID; 23563614; -.
DR KEGG; uma:UMAG_03027; -.
DR VEuPathDB; FungiDB:UMAG_03027; -.
DR eggNOG; KOG0997; Eukaryota.
DR HOGENOM; CLU_014574_2_1_1; -.
DR InParanoid; Q4PA36; -.
DR OMA; PIYISHA; -.
DR OrthoDB; 829786at2759; -.
DR Proteomes; UP000000561; Chromosome 7.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; PTHR13027; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 3: Inferred from homology;
KW Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport; Vacuole.
FT CHAIN 1..887
FT /note="Vacuolar fusion protein MON1"
FT /id="PRO_0000278866"
FT REGION 67..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..313
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 96737 MW; 657198FE0B4686F7 CRC64;
MPQAPKSLSI DSDAAVVAAA AADDLVRASS PRPRTTTFTP SRPTVLLTKS WTSATVLPST
TSTRITVGAN TSTATDAASS ISQHEPSTSS NSTRASTPLP ELSPSPFSPQ TAVAEALTRE
QQPAGPSDDS QSRSILPHAS DHSTPCNSDQ ATEVAFHDAA DVEPEAVGTT VSSSIHALDL
LHRVNDRAAA ERASNSESLR SHLSRLSVSR ASSKHRSRSN SRDASTQTRA LPPAFLGTKQ
AAPSAASAVT QTSLRDEAKD GDRQLYDTSS APSHEEEQYP DRKYYILSSA GKPIYISHAS
LSRRKRRREK RRRQRRAESN ESDLNSNESD EEDESSTTQV GVMQALISIF ADEDSDKLRF
IRRGDLLITF LLRAPLYLVC VSSWNEEPST LRQHLEYLYL QVISLVSASQ LTRLFGRMPN
FDLRRLLEGT EGIFDYLVNQ LNANETEDDD AEQGQHQVAT GGVEAKRAVT DWASCHQWWL
QALQPIRITV PNLRDQLTAA LQPPTAEAGS STQPHRPKDL LYVLLCANGR IVTLLRPRKH
SVHPIDLLLL TNMVMGSRSI KRSGGSEDAE IWLPLSMPKF APHGFVHAYV KFLDPESWIG
SRREGSEMVG DAKMTSSELA VIVVTGDKDA FPTVSAWISS LVAQPPAHWA DNTADDAGDA
GDAGSIRTTD IMAKRAASKK QAGKSAKPTQ TELASWMTHF QRHILTLCRH LTDASNIEQG
SPRVSAYTCA ELGLAGLRHF VYRSNSTIQL TSPSLPDPYA SDAVHRKRLL TLYSLVHHQI
HHPLPASASH SESSSSSTTA PPTGMLNGVF GTPASSHPRL SADTRLKMHL VKSHHEQILG
WITSPFELYL CLNPQLSKSA IVAVANSLTK WIKSNENDLF LVNAGSF
