ID   MON1_YARLI              Reviewed;         543 AA.
AC   Q6CCU8;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Vacuolar fusion protein MON1;
GN   Name=MON1; OrderedLocusNames=YALI0C06347g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for multiple vacuole delivery pathways including the
CC       cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and
CC       endocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar
CC       compartment membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON1/SAND family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG81815.1; -; Genomic_DNA.
DR   RefSeq; XP_501514.1; XM_501514.1.
DR   AlphaFoldDB; Q6CCU8; -.
DR   SMR; Q6CCU8; -.
DR   STRING; 4952.CAG81815; -.
DR   EnsemblFungi; CAG81815; CAG81815; YALI0_C06347g.
DR   GeneID; 2909308; -.
DR   KEGG; yli:YALI0C06347g; -.
DR   VEuPathDB; FungiDB:YALI0_C06347g; -.
DR   HOGENOM; CLU_014574_1_1_1; -.
DR   InParanoid; Q6CCU8; -.
DR   OMA; TKTCAIT; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR   GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR004353; Mon1.
DR   PANTHER; PTHR13027; PTHR13027; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
DR   PRINTS; PR01546; YEAST73DUF.
PE   3: Inferred from homology;
KW   Autophagy; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport; Vacuole.
FT   CHAIN           1..543
FT                   /note="Vacuolar fusion protein MON1"
FT                   /id="PRO_0000278867"
FT   REGION          41..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  60437 MW;  AAFA923166CCEE55 CRC64;
     MEDGAKDDYI KDIYRHASPN ADTDSFLGSP TVAIDSTLST SNSLSNLNLD TNDSSSSPPA
     HNDDVPDIAE VLQEMLATTE LPSSTTDLDY EPELDLVGGH RRNLGQLNDY GSPRADSFVS
     LDPPSIGTEV EQFLSKKKQF FILSSAGKPI YTLHGSDDVI LGYLGVLQTV VSAYQADESG
     DNLMSFRAGK TLVVVAVEGP LILAAVSKIG ESESQLRAQL DVLYTQILST LTKNQIHRIY
     ANQSNFDLRN LLQGTDVYLD ALTREIVNGS PSILLGALEP LILRKSIREE IDGVLLSCRT
     PSLLYGLIVS DSKLANVIRP KKHSLHPPDL ILLFSMLFNT TSFRDGEHWV PICLPKFNST
     GFLYAYIHFF SKSSALIQIS ADKNAFFELR EAKQQILSQM EDKGLIKALE RAEERGRFKP
     VDVAVPMVRH FLYKSRAHVQ YVMPSYETHY YEPHMQRGLL TFYHQLHAQV NSDSSRGSNN
     GWRFMHLVRN SCIGFAWITP SFELYCVSGP NVSRATLAAS IHSIAKWVSQ HRERLFVIGG
     AVF