MON2_CAEEL
ID MON2_CAEEL Reviewed; 1646 AA.
AC Q19338; G5EBK9; Q21561;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Monensin-resistant homolog 2;
GN Name=mon-2; ORFNames=F11A10.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=16219684; DOI=10.1242/jcs.02599;
RA Efe J.A., Plattner F., Hulo N., Kressler D., Emr S.D., Deloche O.;
RT "Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-
RT to-vacuole transport pathway and is required for Golgi homeostasis.";
RL J. Cell Sci. 118:4751-4764(2005).
RN [3]
RP POSSIBLE FUNCTION.
RX PubMed=18497747; DOI=10.1038/emboj.2008.102;
RA Kanamori T., Inoue T., Sakamoto T., Gengyo-Ando K., Tsujimoto M.,
RA Mitani S., Sawa H., Aoki J., Arai H.;
RT "Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C.
RT elegans stem cell divisions.";
RL EMBO J. 27:1647-1657(2008).
CC -!- FUNCTION: May be required for traffic between late Golgi and early
CC endosomes.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q19338-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q19338-2; Sequence=VSP_043941;
CC -!- SIMILARITY: Belongs to the MON2 family. {ECO:0000305}.
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DR EMBL; Z68297; CAA92597.1; -; Genomic_DNA.
DR EMBL; Z68507; CAA92597.1; JOINED; Genomic_DNA.
DR EMBL; Z68297; CCD31054.1; -; Genomic_DNA.
DR EMBL; Z68507; CCD31054.1; JOINED; Genomic_DNA.
DR PIR; T20740; T20740.
DR RefSeq; NP_001255622.1; NM_001268693.1. [Q19338-1]
DR RefSeq; NP_001255623.1; NM_001268694.1. [Q19338-2]
DR AlphaFoldDB; Q19338; -.
DR SMR; Q19338; -.
DR BioGRID; 43246; 2.
DR STRING; 6239.F11A10.4b; -.
DR EPD; Q19338; -.
DR PaxDb; Q19338; -.
DR PeptideAtlas; Q19338; -.
DR PRIDE; Q19338; -.
DR EnsemblMetazoa; F11A10.4a.1; F11A10.4a.1; WBGene00008685. [Q19338-1]
DR EnsemblMetazoa; F11A10.4b.1; F11A10.4b.1; WBGene00008685. [Q19338-2]
DR GeneID; 178153; -.
DR KEGG; cel:CELE_F11A10.4; -.
DR UCSC; F11A10.4; c. elegans. [Q19338-1]
DR CTD; 178153; -.
DR WormBase; F11A10.4a; CE17656; WBGene00008685; mon-2. [Q19338-1]
DR WormBase; F11A10.4b; CE46488; WBGene00008685; mon-2. [Q19338-2]
DR eggNOG; KOG1848; Eukaryota.
DR GeneTree; ENSGT00940000174858; -.
DR HOGENOM; CLU_001169_2_0_1; -.
DR InParanoid; Q19338; -.
DR OMA; DETIDCQ; -.
DR OrthoDB; 411011at2759; -.
DR PhylomeDB; Q19338; -.
DR PRO; PR:Q19338; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00008685; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR026829; Mon2-like.
DR InterPro; IPR032817; Mon2_C.
DR InterPro; IPR032691; Sec7_N.
DR PANTHER; PTHR10663:SF333; PTHR10663:SF333; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF16206; Mon2_C; 1.
DR Pfam; PF12783; Sec7_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Golgi apparatus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..1646
FT /note="Monensin-resistant homolog 2"
FT /id="PRO_0000297906"
FT VAR_SEQ 1497
FT /note="L -> LAS (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043941"
SQ SEQUENCE 1646 AA; 181546 MW; 4B13B919952F895A CRC64;
MSINAVDSKK LVEALLGDLR LLSQEAKKKQ NHVKEAAESG VVRIRNISTA SVGDTVLITN
LRAACTELLH PLVLSCETRH TRLVQIALQG IQRLVQHRIL SQNGATIVTN ELWSLVEAEC
EELRVLQTVP PLVSSELIVT GNTLAKCIVM CFRLHFAKDP IVINAASAAV RQLVSTVFER
VIQEDGIFST ELTVVNPSGG RPSPRAAPPT LRPCAADAYM LFKDLCLLIN GEAPIWLVGI
QETTRTLGLE LLESLLKGFP SVFIRHTEFG DLLKDDVCPL IIRLFSPNVK AMHISSQHPS
SRTSNASFNN YPPTISHERQ SFPISMRLVR IVTLIVQFYQ TILHTECEIF ISTLLKFVDG
DRKGWQRPLA LESLHRIVSS TDLVKWMTES FDCRPNSTHV LEQVAIGLST VVQQCLVCTT
FSSDQENEID RSQEDGGPGF LSKGLWVPYV EHLTSKKTIL LDSLDRMDAV AIPEGYVLSR
CCVALCDMTQ AVYAAIDKLC LVDENSEAGS SETKLEIAKV AYANSQPSIL AAIGSLLAAS
TDEIVSDQLL CCLSTLISAG CRVGADADLH RSVYVLAIMS LPSPSYLNQF AGIAPPSPAN
KRDAPVSEQV FDLEAWPSTT QVTASGPPCP CPVVSTELWN KQVLLTSKNL QAARTFIASI
TTHIKELNNL WYLCMATCEH LSWLLAMRPT QVGQFERETR DDHSNVPTVV TNAALSDIAM
LSSLMDKVAP AIAALPDKSF LSVIDALIRL SDESLAVAAT GRESSLFPLA VLYKVCSLSL
MRLQVFWQKA ANHFIKVCNH TSVSMRDWAA VALTSLAKHA VKSKTSMDAK SQQEMIISSL
LALCSIPHIQ VRRRQLDCVM SLMQTDGAFL LSTSWPNVIQ IISAIIDSDT ECELSLVRQG
YLGLRLVSSD FLQSIPFDCI SGLVEAISRY SKQNTDQNIS LSALTLLWTI SDFIYRKMES
VGNDASEAVW MVLYTCLSES CVDSRFAVRK SACQTLLQTV TAHGHALRSA AWHSVIWQIM
IPLLDKVRSQ TRCASTEKSN GELIMHHSRD TEQKQWTETC IHTISAISKI FNSQRKSLLA
LNDFGAVWEA FLGYLDWAAC YENAELSLSA IRSYQEVLLG KISSQTLNVN SHEKSNGSDS
TIDAITPELP QAQWVESWKV WLRISRGLAR QGCAAMANSV NADSKSISST PRMNSSSSSL
ASLAPGIYVP GPSHLTAILH VFPPLFDKVA KSITVDDLKY ESLPAVLESM MNVPIPSEQA
PFVLPSATTH LTPTQEALLE AVKIVFVECT LSGTSLRAAI PDQIRLLLKF ASMATQRISP
NKVAPGGQKS YRDYALTTIV PFSEYSLRIA IEFFTSTSQN PEVANSLIAI DIIKFLGEPL
YMKYTCISAS TWKLAATSLM SVLRTSIPYA RQNPEVFRGL WSAICDTMER WLFTPNKSTR
LAADERKRDE LMECQAIEII RSEMLAYASR LPQEDVQRLI ALLHRGSISQ IDSTDVLDSH
TQRNELAKAC FDALLMSSDG AHTNTEEDEG RGILGNVAVT SLLQRCTQVM SDFCKDWSAA
GDLRLPRSRI LEIISALQAV DSLIARLARD PKMTELYSHL VSLFPSVVDV MPCCHADPQL
EHQLIKTIKS YQTLFLLQNI PQATVE
