MON2_DROME
ID MON2_DROME Reviewed; 1684 AA.
AC Q9VLT1; A8WHI7; Q961N6; Q9VLT2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 4.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein MON2 homolog;
GN Name=mon2; ORFNames=CG8683;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1202-1684.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=16219684; DOI=10.1242/jcs.02599;
RA Efe J.A., Plattner F., Hulo N., Kressler D., Emr S.D., Deloche O.;
RT "Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-
RT to-vacuole transport pathway and is required for Golgi homeostasis.";
RL J. Cell Sci. 118:4751-4764(2005).
CC -!- FUNCTION: May be required for traffic between late Golgi and early
CC endosomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MON2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK92899.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAT47765.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAT94417.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF52603.4; -; Genomic_DNA.
DR EMBL; BT031133; ABX00755.1; -; mRNA.
DR EMBL; AY051475; AAK92899.1; ALT_INIT; mRNA.
DR EMBL; BT014914; AAT47765.1; ALT_INIT; mRNA.
DR EMBL; BT015188; AAT94417.1; ALT_INIT; mRNA.
DR RefSeq; NP_001033884.2; NM_001038795.3.
DR RefSeq; NP_001285739.1; NM_001298810.1.
DR AlphaFoldDB; Q9VLT1; -.
DR BioGRID; 77411; 8.
DR IntAct; Q9VLT1; 2.
DR STRING; 7227.FBpp0290447; -.
DR PaxDb; Q9VLT1; -.
DR PRIDE; Q9VLT1; -.
DR DNASU; 326157; -.
DR EnsemblMetazoa; FBtr0301229; FBpp0290447; FBgn0031985.
DR EnsemblMetazoa; FBtr0339674; FBpp0308731; FBgn0031985.
DR GeneID; 326157; -.
DR KEGG; dme:Dmel_CG8683; -.
DR UCSC; CG8683-RA; d. melanogaster.
DR CTD; 23041; -.
DR FlyBase; FBgn0031985; mon2.
DR VEuPathDB; VectorBase:FBgn0031985; -.
DR eggNOG; KOG1848; Eukaryota.
DR HOGENOM; CLU_001169_2_0_1; -.
DR InParanoid; Q9VLT1; -.
DR OMA; DETIDCQ; -.
DR OrthoDB; 411011at2759; -.
DR PhylomeDB; Q9VLT1; -.
DR BioGRID-ORCS; 326157; 0 hits in 1 CRISPR screen.
DR ChiTaRS; mon2; fly.
DR GenomeRNAi; 326157; -.
DR PRO; PR:Q9VLT1; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031985; Expressed in seminal fluid secreting gland and 24 other tissues.
DR ExpressionAtlas; Q9VLT1; baseline and differential.
DR Genevisible; Q9VLT1; DM.
DR GO; GO:0005768; C:endosome; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0005519; F:cytoskeletal regulatory protein binding; IPI:FlyBase.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; IMP:FlyBase.
DR GO; GO:0007318; P:pole plasm protein localization; IMP:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR026829; Mon2-like.
DR InterPro; IPR032817; Mon2_C.
DR InterPro; IPR015403; Sec7_C.
DR InterPro; IPR032691; Sec7_N.
DR PANTHER; PTHR10663:SF333; PTHR10663:SF333; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF09324; DUF1981; 1.
DR Pfam; PF16206; Mon2_C; 1.
DR Pfam; PF12783; Sec7_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..1684
FT /note="Protein MON2 homolog"
FT /id="PRO_0000297907"
SQ SEQUENCE 1684 AA; 186993 MW; 49E2FC9077614D50 CRC64;
MSFVGGGGCG GQDVHKFVEA LQADFKTLSL ETKKKYPQIK EACEEAISKL CTAGSSQQNS
VYYTVNQILY PLVQGCETKD LKIIKFCLGM MQRLITQQVV DQKGALYITN ALWTLMENNI
EEVKVLQTVT LLLTTNTVVH GDTLAKALVL CFRLHYAKNP TIVNTAGATI RQLVSLVFER
VYLEKDSVSS LQQQQSSGSP AEGEGGNQDV QTFASDAFLL FQDLVQLVNA DQPYWLLGMT
EMTRTFGLEL LEAVLTNFSA VFHESNDFRL LLKERVCALV IKLFSPNVKH RQLPAPSNGN
APVPAEKPYF PISMRLLRLV AILIQKYHTI LVTECEIFLS LIIKFLDPDK PAWQRALALE
VIHKLVTRSS LIAFFCKSYD LKNHATNIVH DMIAAMGSYI RYSLINASAM LNGQQNGVAN
SLTAMSGSNQ CGFMFRGAYL PLVATYAPGV SKAVYLEMLD KIDASNIPDS YGISVGHAIL
LDMTRSIGGV IQRTPELHPS HNTAVITEEE HKPLCLQLVN SSWSALLSAF IPLVETSIDE
ATTENILKAM QNYAALCGML EQLQPRDAFI MAMCRASFPP HYAMSIFANT TQSDGDLRCH
TRSGSQDLSS QFINSCSGDA GDFRPQIVAV GTPLPSASLP HSVMQAPVML TNKNLQCMRA
ILFLAHNNGG ILGTSWHIVL QTLQHLVWIL GLKPSTGGSL QAMPKPAVEA NVGIQTAVMA
DLPVLSQMLS QLFESSQYLD DVALHHLIDA LCKLSHEAME LAYANREPSL FAVAKLLETG
LVNMPRIKVL WRPLTNHLLE VCQHRHIRMR EWGVEAITYL VKSALQFKHK TPLKENMELQ
TMLLSPLSEL STVLHADVRQ RQLDCVLQIL NTAGEILSFG WPAIIEIIGA VNEHHGEPLI
RTAFQCLQLV ITDFLTVMPW RCLPLCISTA AKFGSQTQEL NISLTAIGLM WNISDFFNQN
QDKLMSTQLQ DVSILPDFPG TVKMPQFDKL WMCLYAKLGE LCVDLRPAVR KSAGQTLFST
ISAHGSLLNP PTWQALVWQV LFPLLDNVRA LSSSASNEKV DASGNILIHH SRNTAQKQWA
ETQVLTLSGV CRVFNTKREL LQMLGDFERA WSLILEFIQN AALSKNGEVS LAALKSLQEI
MYHNTAERTE RALKDPQTAQ EQDEEIWTIA WNIWLSIGME STKMSTSTSA KLQQQNSNGA
ETQEDFYIPS QAFLTALIQI FPAIFQHIQV KFTAADFDKF CTVLTNAVCI PVQTDAVPYI
MSTVSDTLLT PLHDGILDCM ELIQKEATKP DSHISQLIPA IFRQLLIFSK FACAPPTFQQ
SVEHKYAKSS GHYANNASVE VVSMNYIPFG EKSISICVKL YQTTATEDSV VQEQILHDIV
KALRTPLAMK YKCLSSSTWK LAISSLISVL HTGLKVARAK PQHFASLWDD LADTLDKFLF
PASVCTIEDR GLEEIVLDET IDCQVIELLR DEVLPHSHEM PHQFIMQIVV LLNKGSIHSA
SDTNICYESD WKLREIFAKT CFETLLQFSL LEDHANTNNN RLNANVLTAG AAGAGGKDFA
GRLAVTALLH RFQEVLKRFN DDERQSGKCP LPRFRLSEIS FVLKAIATLV VSMKKAPASK
VNKPAWDQLI GLYPYLVDCT TTTSPEVSRS LREALLQYTD LLQAPRSCSA ATSNDNVIQS
NGQE
