ID   MON2_DROPS              Reviewed;        1701 AA.
AC   Q29L43;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein MON2 homolog;
GN   Name=mon2; ORFNames=GA16450;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: May be required for traffic between late Golgi and early
CC       endosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL32981.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH379061; EAL32981.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_015036558.1; XM_015181072.1.
DR   AlphaFoldDB; Q29L43; -.
DR   STRING; 7237.FBpp0287710; -.
DR   EnsemblMetazoa; FBtr0368749; FBpp0331457; FBgn0076465.
DR   GeneID; 4816705; -.
DR   KEGG; dpo:Dpse_GA16450; -.
DR   eggNOG; KOG1848; Eukaryota.
DR   InParanoid; Q29L43; -.
DR   ChiTaRS; mon2; fly.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0076465; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032629; DCB_dom.
DR   InterPro; IPR026829; Mon2-like.
DR   InterPro; IPR032817; Mon2_C.
DR   InterPro; IPR015403; Sec7_C.
DR   InterPro; IPR032691; Sec7_N.
DR   PANTHER; PTHR10663:SF333; PTHR10663:SF333; 1.
DR   Pfam; PF16213; DCB; 1.
DR   Pfam; PF09324; DUF1981; 1.
DR   Pfam; PF16206; Mon2_C; 2.
DR   Pfam; PF12783; Sec7_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1701
FT                   /note="Protein MON2 homolog"
FT                   /id="PRO_0000297908"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1199..1219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1701 AA;  188689 MW;  FE95D50498E7DB30 CRC64;
     MSFVGGGGGQ DVHKFVEALQ ADFKTLSLET KKKYPQIKEA CEEAISKLCT AGSSQQNSVY
     YTVNQILYPL VQGCETKDLK IIKFCLGMMQ RLITQQVVDQ KGALYITNAL WTLMENNIEE
     VKVLQTVTLL LTTNTVVHGD TLAKALVLCF RLHYTKNPTI VNTAGATIRQ LVSLVFERVY
     LEKDSVPSLQ QQQQQPSSSS NGPVEADGAT AGQDVQTFAS DAFLLFQDLV QLVNAEQPYW
     LVGMTEMTRT FGLELLEAVL TNFSAVFHES NDFRLLLKER VCALVIKLFS PNVKHRQLPA
     PNNGTAPVPA EKPYFPISMR LLRLVSILIQ KYHTILVTEC EIFLSLIIKF LDPDKPAWQR
     ALAVEVIHKL VTRSSLIAFF CKSYDLKNHA TNIVHDMIAA MGSFVRYSLI NASVMLNGQQ
     NGGVLAQPTN ALSTLSGNNQ CGFSFRGAYL PLVATYAPGV SKAVYLEMLD KLDAPNIPDS
     YGISVGHAIL LDMTRSIGGV IQRTPELHPT HNTAVITEEE HQPLCLQLVN SSWSGLLSAF
     IPLVETSMDE ATTENILKAM QNYAALCGML EQLQPRDAFI MAMCRASFPP HYAMSIFANA
     TQSDGDVRCH TRSGSQDLSS QFINSCTPDD FRPQIVAVGT PLPSASLPHS VMQAPVMLTN
     KNLQCMRAIL FLAHNNGGIL GTSWHMVLQT LQHLVWILGL KPSTGGSLQA MPKPAVEANV
     GIQTAVMADL PVLSQMLSQL FESSQYLDDV ALHHLIDALC KLSHEAMELA YANREPSLFA
     VAKLLETGLV NMPRINVLWR PLTNHLLEVC QHRHIRMREW GVEAITYLVK SALQFKHKTP
     LKENMELQTM LLSPLSELST VLHADVRQRQ LDCVLQILNT AGEILSFGWP AIIEIIGAVN
     EHHGEPLIRT AFQCLQLVIT DFLTVMPWRC LPLCISTAAK FGSQTQELNI SLTAIGLMWN
     ISDFFNQNQD KLMSTQLQDV AILPEFPGTV KMPQFDKLWM CLYAKLGELC VDLRPAVRKS
     AGQTLFSTIS AHGSLLNPPT WQALVWQVLF PLLDNVRALS SSASNEKVDA SGNILIHHSR
     NTAQKQWAET QVLTLSGVCR VFNTKRELLQ MLGDFERAWS LILEFIQNAA LSKNGEVSLA
     ALKSLQEIMY HNTTTERTVG GVGGASLKDP QTTQEQDEEI WTIAWNIWLS IGMESTKMST
     TKAQPQPSSN GGSNGSQDSQ EDFYIPSQAF LTALIQIFPA IFHHIQVKFS PTDFDKFCTV
     LTNAVCIPVQ TDAVPYIMST VSDTLLTPLH DGILDCMELI QKEATKPDSH ISQLIPAIFR
     QLLIFSKFAC APPTFQQNVE HKYAKSTSGH YANNASVEVV GMNYIPFGEK SISICVKLYQ
     TTATEESVVQ EQILHDIVKA VRTPLAMKYK CLSSSTWKLA ISSLISVLHT GLKVARAKPQ
     HFASLWDDLA DTLDKFLFPA SVCTIEDRGL EEIVLDETID CHVIELLRDE VLPHAHEMPH
     QFIMQIVVLL NKGSIHSASD TNICYESDWK LREIFAKTCF ETLLQFSLLE DHHATNNNRI
     NANLLPAGAA GAVGKDFAGR LAVTALLHRF QEVLKRFNDD ERQSGKCPLP RFRLSEISFV
     LKAIATLVVS MKKAPASKVN KPAWDQLIGL YPYLVDCTTT TSPEVSRSLR EALLQYTDLL
     QAPRLCGATT NDNSIQSNGQ E