ID   MON2_SCHPO              Reviewed;        1616 AA.
AC   Q09853;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Protein MON2 homolog;
GN   Name=mon2; ORFNames=SPAC23D3.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=16219684; DOI=10.1242/jcs.02599;
RA   Efe J.A., Plattner F., Hulo N., Kressler D., Emr S.D., Deloche O.;
RT   "Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-
RT   to-vacuole transport pathway and is required for Golgi homeostasis.";
RL   J. Cell Sci. 118:4751-4764(2005).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-660, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Required for traffic between late Golgi and early endosomes.
CC       Required for endocytosis and maintenance of vacuolar structure (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Note=Late Golgi.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MON2 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA91248.1; -; Genomic_DNA.
DR   PIR; T38288; S62504.
DR   RefSeq; NP_594550.1; NM_001019979.2.
DR   AlphaFoldDB; Q09853; -.
DR   SMR; Q09853; -.
DR   BioGRID; 277988; 1.
DR   STRING; 4896.SPAC23D3.13c.1; -.
DR   iPTMnet; Q09853; -.
DR   MaxQB; Q09853; -.
DR   PaxDb; Q09853; -.
DR   PRIDE; Q09853; -.
DR   EnsemblFungi; SPAC23D3.13c.1; SPAC23D3.13c.1:pep; SPAC23D3.13c.
DR   GeneID; 2541486; -.
DR   KEGG; spo:SPAC23D3.13c; -.
DR   PomBase; SPAC23D3.13c; -.
DR   VEuPathDB; FungiDB:SPAC23D3.13c; -.
DR   eggNOG; KOG1848; Eukaryota.
DR   HOGENOM; CLU_001169_1_0_1; -.
DR   InParanoid; Q09853; -.
DR   OMA; DETIDCQ; -.
DR   PhylomeDB; Q09853; -.
DR   PRO; PR:Q09853; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005768; C:endosome; ISO:PomBase.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:PomBase.
DR   GO; GO:0006897; P:endocytosis; ISO:PomBase.
DR   GO; GO:0006623; P:protein targeting to vacuole; ISO:PomBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032629; DCB_dom.
DR   InterPro; IPR026829; Mon2-like.
DR   InterPro; IPR032817; Mon2_C.
DR   InterPro; IPR032691; Sec7_N.
DR   PANTHER; PTHR10663:SF333; PTHR10663:SF333; 1.
DR   Pfam; PF16213; DCB; 1.
DR   Pfam; PF16206; Mon2_C; 1.
DR   Pfam; PF12783; Sec7_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..1616
FT                   /note="Protein MON2 homolog"
FT                   /id="PRO_0000116419"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         660
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   1616 AA;  181451 MW;  CB44B34EE2D568DA CRC64;
     MSLYDSLLSN LQSINVDTRK KNADLKKLAD GSLKFLYTNK NLSQDSLVSK LKGNEAFYKP
     FLFCCAKKIE RHIYISLNSI QLLAINDALS PDILESLFNS LNAVIQLGQD SQLRVLQIIP
     IICTHYAASM KLPILISLFR ICFNLHNSKN SVVSNAAAAT LRQIVILVFD YLDYDTLAHK
     QEADLFLDSL SLFKGLCSLL SAGKSESLNV DHISTTFGLE LLESILVNHH RLFQIPEFQD
     SVRKDLLPII TASLASMSDF PVALRISRIL NIIFQHYVTS LTLDIEVIFS FIISSLDNSE
     AAWKKALFLE VLRSIFSNTN LLYLMYTLFD GNEGRKPIIK KLVTSLSRIV NEKPSVIGVG
     SRVVLADTFE DYSSTSSGNP PSSMEKVSGS FTGTKPEQII GICRATILKT PCIEQFDKQE
     PPIIPFAYLV YLAMCSLASI SNGIADFVFQ FYEDVGKKEF TLLIEGIKCE NFDSKEDSTA
     RPQNIIKCQY GLISENWTSF LVAYSTFVSS ALAVELLKFC LNSYVNFVSV CTLFGLETPR
     DALLTTLSNK AVPSNLLSGN MTHSASSSIS HNGRLSTSTM FSVEGLKEAA TTIAAIASYD
     SNHDEKQKCF SLREILFLRC LSSIAKVVGE KMGKGWKILF ETFDKADIIL NRSPTSKHLS
     TSSLNRVNSS NSNFQDSKSF STLMDYELVS YKNELSELMY VTSSYSQPAY MEFLESLLAV
     ITSSSVHPIQ TLTAPRQSFN EDLLSANTKN SVYKTSANRS ISGGIRLLRK SSEVFYSFSI
     LETVCSCNLD RFLDSKLDHS GWSLISKSLS EVFKIINVAP ELRTRAANCL ANILVDVASR
     LSNENSPDSY AFQEIFFESL GMLLPVTEVS DNTSRGVEYD ISTIGLEALV SILETVGHHV
     LHGWQYVFEM LRFNCLNGAT CFGSEKGAKI VRLAFSCLQL ICTDFLASLD TSNYLDLMDT
     LLVFCRQLED ANVSLTAVGL FWNVSDTLKN MFSTSDFSCA YNSVEDLYAF TSMKSKEILP
     EVLWIMLLVH LADLCENSWA SVRNGAAQIL FRIFNSQCSK LGTNAWASCC QLVIMKLLHS
     QPIQNVSDVN NKKDEDDHEQ TSCLIISGIA DVFSENMSLL LNVNGILDVL EEAFQLMLRL
     HSDIYPKICI SNFKALRELS FSISEFGKEN ATFTLLIKLV FINWGRFCEV SFSERRLANI
     SQEGLTLLIE SVVFLLKAYN FGIEEIKDSL LQVRKAVFYE ESTSFALDVD FLSSLQLAVE
     SLTDLLISKF KLNHLVLELW SDVLTYAFNE EKTIRASLPT LICLSKKIFE NAENVVENHS
     LDFLNRGTMQ HMFESLLVPM RLKYRCPKAS RVNQSTLPIW VLASKCFVRL MINCFKDLKG
     SDAIEDAEKM QCLFLLTVEA TNSIISPNAD YEYVWSLEDV FENEDVSSLK QLHNLWKPHL
     QLNCLSDEVA QYYITLCKGS FYYQMRNTED MVISRSNLDI QKEAARNFFP STESPVSNRR
     QRIAVDCFSI LLDDYNSSYE HVSLTIRPIL QSRLCWSLKR YVADKSVSGY LPLSKSQEMD
     MSTVAECLNN HPSLYSNPIH YLLRKAYHTT NASPVATSLN AILGQLTLKN EVLNAI