MOODY_DROPS
ID MOODY_DROPS Reviewed; 675 AA.
AC Q29J90;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=G-protein coupled receptor moody {ECO:0000250|UniProtKB:Q9W534};
GN Name=moody {ECO:0000250|UniProtKB:Q9W534}; ORFNames=GA18107;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required in glia to regulate the acute sensitivity to cocaine
CC and to continuously maintain the proper blood-brain barrier (BBB)
CC function. A moody-mediated signaling pathway functions in glia to
CC regulate nervous system insulation and drug-related behaviors (By
CC similarity). {ECO:0000250|UniProtKB:Q9W534}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9W534};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9W534}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; CH379063; EAL32411.2; -; Genomic_DNA.
DR RefSeq; XP_001355354.2; XM_001355318.3.
DR RefSeq; XP_015041049.1; XM_015185563.1.
DR AlphaFoldDB; Q29J90; -.
DR SMR; Q29J90; -.
DR STRING; 7237.FBpp0273001; -.
DR EnsemblMetazoa; FBtr0274563; FBpp0273001; FBgn0078115.
DR EnsemblMetazoa; FBtr0379275; FBpp0339928; FBgn0078115.
DR GeneID; 4816028; -.
DR KEGG; dpo:Dpse_GA18107; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_421673_0_0_1; -.
DR InParanoid; Q29J90; -.
DR OMA; QTCSIMS; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0078115; Expressed in insect adult head and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005919; C:pleated septate junction; IEA:EnsemblMetazoa.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0008366; P:axon ensheathment; ISS:UniProtKB.
DR GO; GO:0048148; P:behavioral response to cocaine; ISS:UniProtKB.
DR GO; GO:0048149; P:behavioral response to ethanol; IEA:EnsemblMetazoa.
DR GO; GO:0035095; P:behavioral response to nicotine; IEA:EnsemblMetazoa.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0060857; P:establishment of glial blood-brain barrier; IEA:EnsemblMetazoa.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0019991; P:septate junction assembly; IEA:EnsemblMetazoa.
DR GO; GO:0007419; P:ventral cord development; IEA:EnsemblMetazoa.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..675
FT /note="G-protein coupled receptor moody"
FT /id="PRO_0000355098"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..359
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..675
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 258..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..507
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..610
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 113..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 675 AA; 72863 MW; 15E50ECCA42AF7C0 CRC64;
MSDETTGSLG DAFSPMDTPT TTIMPPPADV DESGFSHSLL TFAAVMTFLI MIVGICGNLL
TVVALLKCPK VRNVAAAFII SLCIADLLFC ALVLPFQGLR FVQGTWRHGE VLCRLIPFIQ
YGNIGVSLLC IAMITINRYV MITHYSLYNR IYKRHWIAIM IAACWLFSYG MQLPTLLGAW
GRFGYDARLQ TCSIMSDRHG HSSKTTLFIT AFVIPCLVII ACYAKIFWVV HKSEQRLKRH
ATKQNSIPNN LRPLAAATSM PSGDGANPSQ VPAGCRVSSD SSSNYSTDVP DTTPGGAGGG
AGVKQQPSRV KDQREVRAKR NEWRITKMVL AIFLSFVICY LPITIVKVAD KDVEHPSLHI
FSYIMLYLSA CINPIIYVIM NKQYRKAYKT VVFCQPAARL LMPFGKGNGA SSAAEKWKDT
GLSNNHSRTI VSQMSAGATA TATATAAAGT QPQSTSTQGP VQALELTARV PDLISKSSNL
PLPQPLPQIP PAGARPSLTP PPPPSVLTAT HSNGSGSQRL PLKKNNHSYT NSGFNSSVIS
ANPSSSPSPS SSGGGIYRPG IGSMGNGSAS IRRITMVGDD IILEEEELPP TPTASSPPQM
QAPPPPPSSS RQTTMNALNT TPKTPIYMNV DSPKRNQSYS ERNIPVPARE GHDQGVKDSQ
GLPSKLMDKK KFPKD
