MOR1A_CHICK
ID MOR1A_CHICK Reviewed; 300 AA.
AC Q2YHT7; Q2YHT6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cell surface glycoprotein CD200 receptor 1-A;
DE AltName: Full=CD200 cell surface glycoprotein receptor 1-A;
DE AltName: Full=Cell surface glycoprotein OX2 receptor 1-A;
DE Flags: Precursor;
GN Name=CD200R1A;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PHOSPHORYLATION,
RP GLYCOSYLATION, AND TISSUE SPECIFICITY.
RC STRAIN=M11;
RX PubMed=18062907; DOI=10.1016/j.molimm.2007.10.012;
RA Viertlboeck B.C., Hanczaruk M.A., Schmitt F.C., Schmitt R., Goebel T.W.;
RT "Characterization of the chicken CD200 receptor family.";
RL Mol. Immunol. 45:2097-2105(2008).
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass
CC type I membrane protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=ggCD200R-B1;
CC IsoId=Q2YHT7-1; Sequence=Displayed;
CC Name=2; Synonyms=ggCD200R-B1sv;
CC IsoId=Q2YHT7-2; Sequence=VSP_035000, VSP_035001;
CC -!- TISSUE SPECIFICITY: Highly expressed in macrophages, peripheral blood
CC lymphocytes (PBL) and peripheral blood mononuclear cells (PBMC). Weakly
CC expressed in bursa, thymus, spleen, liver and brain.
CC {ECO:0000269|PubMed:18062907}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:18062907}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:18062907}.
CC -!- SIMILARITY: Belongs to the CD200R family. {ECO:0000305}.
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DR EMBL; AM076728; CAJ28370.1; -; mRNA.
DR EMBL; AM076729; CAJ28371.1; -; mRNA.
DR RefSeq; NP_001072952.1; NM_001079484.1. [Q2YHT7-1]
DR AlphaFoldDB; Q2YHT7; -.
DR SMR; Q2YHT7; -.
DR STRING; 9031.ENSGALP00000029812; -.
DR PaxDb; Q2YHT7; -.
DR Ensembl; ENSGALT00000084079; ENSGALP00000063880; ENSGALG00000019231. [Q2YHT7-2]
DR GeneID; 768673; -.
DR KEGG; gga:768673; -.
DR CTD; 768673; -.
DR VEuPathDB; HostDB:geneid_768673; -.
DR eggNOG; ENOG502SPS1; Eukaryota.
DR GeneTree; ENSGT00390000014496; -.
DR HOGENOM; CLU_069156_0_1_1; -.
DR InParanoid; Q2YHT7; -.
DR PhylomeDB; Q2YHT7; -.
DR TreeFam; TF335960; -.
DR Reactome; R-GGA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR PRO; PR:Q2YHT7; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000019231; Expressed in spleen and 13 other tissues.
DR ExpressionAtlas; Q2YHT7; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR21462; PTHR21462; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Secreted;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..300
FT /note="Cell surface glycoprotein CD200 receptor 1-A"
FT /id="PRO_0000346450"
FT TOPO_DOM 25..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..124
FT /note="Ig-like V-type"
FT DOMAIN 122..206
FT /note="Ig-like C2-type"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 210..244
FT /note="SYRDLILCIAIILSFLIIITFMAVIYYLKLHGCRF -> YSVTEANLLILFL
FT HIPHRMTQWRWNPILLTCRRKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18062907"
FT /id="VSP_035000"
FT VAR_SEQ 245..300
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18062907"
FT /id="VSP_035001"
SQ SEQUENCE 300 AA; 33519 MW; 6B73422A52E820D1 CRC64;
MEIAGKAVCV FLLLAIIKLR RSEGINRVSA NLGHNTVMTC PTRTNISMVT WKINPKTGHQ
CTLAYRIDKD STGKTNCSDR INWRSRPDWD QALEIQQVGK ADEGNYTCEV VNADGNFHRL
YHLTVIVAPR MALYCDDYGN PVCEAETEKS AAEISWVPES NSTPRADSHD NGTVTVVSWF
AARSTNGKNP TCIVSHATLN ETKSINCSSS YRDLILCIAI ILSFLIIITF MAVIYYLKLH
GCRFCHRSKP PDIIPTYSSQ DDTVEVEPYT TYVQKENVIY NSVSDLTLRQ NLPQGQSPAT
