MORC1_HUMAN
ID MORC1_HUMAN Reviewed; 984 AA.
AC Q86VD1; B4DYX1; E7ERX1; Q7L8E2; Q9NSG7; Q9Y6D4;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=MORC family CW-type zinc finger protein 1;
DE AltName: Full=Cancer/testis antigen 33;
DE Short=CT33;
GN Name=MORC1 {ECO:0000312|EMBL:AAH50307.1};
GN Synonyms=MORC {ECO:0000312|EMBL:AAD43004.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAD43004.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ILE-470 AND TYR-836.
RX PubMed=10369865; DOI=10.1093/hmg/8.7.1201;
RA Inoue N., Hess K.D., Moreadith R.W., Richardson L.L., Handel M.A.,
RA Watson M.L., Zinn A.R.;
RT "New gene family defined by MORC, a nuclear protein required for mouse
RT spermatogenesis.";
RL Hum. Mol. Genet. 8:1201-1207(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS ILE-470
RP AND TYR-836.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4] {ECO:0000312|EMBL:AAH50307.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-470.
RC TISSUE=Testis {ECO:0000312|EMBL:AAH50307.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-984 (ISOFORM 1), AND VARIANTS
RP ILE-470 AND TYR-836.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Required for spermatogenesis (By similarity). Essential for
CC de novo DNA methylation and silencing of transposable elements in the
CC male embryonic germ cells (By similarity).
CC {ECO:0000250|UniProtKB:Q9WVL5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WVL5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86VD1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86VD1-2; Sequence=VSP_055495;
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DR EMBL; AF084946; AAD43004.1; -; mRNA.
DR EMBL; AK302642; BAG63883.1; -; mRNA.
DR EMBL; AC016948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050307; AAH50307.1; -; mRNA.
DR EMBL; AL353955; CAB89255.1; -; mRNA.
DR CCDS; CCDS2955.1; -. [Q86VD1-1]
DR PIR; T48690; T48690.
DR RefSeq; NP_055244.3; NM_014429.3. [Q86VD1-1]
DR AlphaFoldDB; Q86VD1; -.
DR SMR; Q86VD1; -.
DR BioGRID; 118026; 10.
DR IntAct; Q86VD1; 4.
DR STRING; 9606.ENSP00000232603; -.
DR iPTMnet; Q86VD1; -.
DR PhosphoSitePlus; Q86VD1; -.
DR BioMuta; MORC1; -.
DR DMDM; 269849621; -.
DR EPD; Q86VD1; -.
DR jPOST; Q86VD1; -.
DR MassIVE; Q86VD1; -.
DR MaxQB; Q86VD1; -.
DR PaxDb; Q86VD1; -.
DR PeptideAtlas; Q86VD1; -.
DR PRIDE; Q86VD1; -.
DR ProteomicsDB; 17870; -.
DR ProteomicsDB; 69986; -. [Q86VD1-1]
DR Antibodypedia; 32406; 126 antibodies from 19 providers.
DR DNASU; 27136; -.
DR Ensembl; ENST00000232603.10; ENSP00000232603.5; ENSG00000114487.10. [Q86VD1-1]
DR Ensembl; ENST00000483760.1; ENSP00000417282.1; ENSG00000114487.10. [Q86VD1-2]
DR GeneID; 27136; -.
DR KEGG; hsa:27136; -.
DR MANE-Select; ENST00000232603.10; ENSP00000232603.5; NM_014429.4; NP_055244.3.
DR UCSC; uc003dxl.4; human. [Q86VD1-1]
DR CTD; 27136; -.
DR DisGeNET; 27136; -.
DR GeneCards; MORC1; -.
DR HGNC; HGNC:7198; MORC1.
DR HPA; ENSG00000114487; Tissue enriched (testis).
DR MIM; 603205; gene.
DR neXtProt; NX_Q86VD1; -.
DR OpenTargets; ENSG00000114487; -.
DR PharmGKB; PA30906; -.
DR VEuPathDB; HostDB:ENSG00000114487; -.
DR eggNOG; KOG1845; Eukaryota.
DR GeneTree; ENSGT00940000153998; -.
DR HOGENOM; CLU_011516_0_1_1; -.
DR InParanoid; Q86VD1; -.
DR OMA; LDIWICA; -.
DR OrthoDB; 193855at2759; -.
DR PhylomeDB; Q86VD1; -.
DR TreeFam; TF329118; -.
DR PathwayCommons; Q86VD1; -.
DR SignaLink; Q86VD1; -.
DR BioGRID-ORCS; 27136; 12 hits in 1064 CRISPR screens.
DR ChiTaRS; MORC1; human.
DR GenomeRNAi; 27136; -.
DR Pharos; Q86VD1; Tbio.
DR PRO; PR:Q86VD1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86VD1; protein.
DR Bgee; ENSG00000114487; Expressed in testis and 30 other tissues.
DR Genevisible; Q86VD1; HS.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0044026; P:DNA hypermethylation; IEA:Ensembl.
DR GO; GO:0043046; P:DNA methylation involved in gamete generation; IEA:Ensembl.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:2000143; P:negative regulation of DNA-templated transcription, initiation; IEA:Ensembl.
DR GO; GO:0010529; P:negative regulation of transposition; IEA:Ensembl.
DR GO; GO:0040029; P:regulation of gene expression, epigenetic; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR GO; GO:0032196; P:transposition; IEA:Ensembl.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR041006; Morc_S5.
DR InterPro; IPR011124; Znf_CW.
DR Pfam; PF17942; Morc6_S5; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Developmental protein; Differentiation;
KW Metal-binding; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW Spermatogenesis; Zinc; Zinc-finger.
FT CHAIN 1..984
FT /note="MORC family CW-type zinc finger protein 1"
FT /id="PRO_0000248241"
FT ZN_FING 477..531
FT /note="CW-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT COILED 284..353
FT /evidence="ECO:0000255"
FT COILED 737..761
FT /evidence="ECO:0000255"
FT COILED 900..934
FT /evidence="ECO:0000255"
FT BINDING 486
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 489
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 512
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 523
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT VAR_SEQ 569..589
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055495"
FT VARIANT 153
FT /note="T -> P (in dbSNP:rs35282274)"
FT /id="VAR_051188"
FT VARIANT 322
FT /note="K -> M (in dbSNP:rs17225637)"
FT /id="VAR_051189"
FT VARIANT 462
FT /note="D -> E (in dbSNP:rs3762696)"
FT /id="VAR_059698"
FT VARIANT 470
FT /note="F -> I (in dbSNP:rs4855576)"
FT /evidence="ECO:0000269|PubMed:10369865,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_051190"
FT VARIANT 478
FT /note="M -> V (in dbSNP:rs3762697)"
FT /id="VAR_051191"
FT VARIANT 649
FT /note="M -> I (in dbSNP:rs35421732)"
FT /id="VAR_051192"
FT VARIANT 767
FT /note="S -> N (in dbSNP:rs2290057)"
FT /id="VAR_051193"
FT VARIANT 836
FT /note="H -> Y (in dbSNP:rs2593943)"
FT /evidence="ECO:0000269|PubMed:10369865,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:17974005"
FT /id="VAR_051194"
FT VARIANT 982
FT /note="S -> C (in dbSNP:rs16855035)"
FT /id="VAR_051195"
FT VARIANT 982
FT /note="S -> W (in dbSNP:rs16855035)"
FT /id="VAR_051196"
FT CONFLICT 65
FT /note="F -> C (in Ref. 2; BAG63883)"
FT /evidence="ECO:0000305"
FT CONFLICT 692
FT /note="K -> E (in Ref. 2; BAG63883)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 984 AA; 112881 MW; 613163D31E2317A6 CRC64;
MDDRYPALQR AQLRLDFIHA NSTTHSFLFG ALAELLDNAR DAGAERLDVF SVDNEKLQGG
FMLCFLDDGC GMSPEEASDI IYFGRSKKRL STLKFIGQYG NGLKSGSMRI GKDFILFTKK
EETMTCVFFS QTFCEEESLS EVVVPMPSWL IRTRESVTDD PQKFAMELSI IYKYSPFKTE
AELMQQFDVI YGKCGTLLVI YNLKLLLNGE PELDVKTDKE DILMAGALED FPARWSFRAY
TSVLYFNPWM RIFIQAKRVK TKHLCYCLYR PRKYLYVTSS FKGAFKDEVK KAEEAVKIAE
SILKEAQIKV NQCDRTSLSS AKDVLQRALE DVEAKQKNLK EKQRELKTAR TLSLFYGVNV
ENRSQAGMFI YSNNRLIKMH EKVGSQLKLK SLLGAGVVGI VNIPLEVMEP SHNKQEFLNV
QEYNHLLKVM GQYLVQYCKD TGINNRNLTL FCNEFGYQND IDVEKPLNSF QYQRRQAMGI
PFIIQCDLCL KWRVLPSSTN YQEKEFFDIW ICANNPNRLE NSCHQVECLP SIPLGTMSTI
SPSKNEKEKQ LRESVIKYQN RLAEQQPQPQ FIPVDEITVT STCLTSAHKE NTKTQKIRLL
GDDLKHESLS SFELSASRRG QKRNIEETDS DVEYISETKI MKKSMEEKMN SQQQRIPVAL
PENVKLAERS QRSQIANITT VWRAQPTEGC LKNAQAASWE MKRKQSLNFV EECKVLTEDE
NTSDSDIILV SDKSNTDVSL KQEKKEIPLL NQEKQELCND VLAMKRSSSL PSWKSLLNVP
MEDVNLSSGH IARVSVSGSC KVASSPASSQ STPVKETVRK LKSKLREILL YFFPEHQLPS
ELEEPALSCE LEQCPEQMNK KLKMCFNQIQ NTYMVQYEKK IKRKLQSIIY DSNTRGIHNE
ISLGQCENKR KISEDKLKNL RIKLALLLQK LQLGGPEGDL EQTDTYLEAL LKEDNLLFQN
NLNKVTIDAR HRLPLEKNEK TSEN
