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MORC1_MOUSE
ID   MORC1_MOUSE             Reviewed;         950 AA.
AC   Q9WVL5;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=MORC family CW-type zinc finger protein 1;
DE   AltName: Full=Protein microrchidia;
GN   Name=Morc1 {ECO:0000312|MGI:MGI:1316740};
GN   Synonyms=Morc {ECO:0000312|EMBL:AAD43003.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAD43003.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=10369865; DOI=10.1093/hmg/8.7.1201;
RA   Inoue N., Hess K.D., Moreadith R.W., Richardson L.L., Handel M.A.,
RA   Watson M.L., Zinn A.R.;
RT   "New gene family defined by MORC, a nuclear protein required for mouse
RT   spermatogenesis.";
RL   Hum. Mol. Genet. 8:1201-1207(1999).
RN   [2] {ECO:0000312|EMBL:AAH30893.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N {ECO:0000312|EMBL:AAH30893.1};
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH30893.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=26275923; DOI=10.1016/j.bbr.2015.08.005;
RA   Schmidt M., Brandwein C., Luoni A., Sandrini P., Calzoni T., Deuschle M.,
RA   Cirulli F., Riva M.A., Gass P.;
RT   "Morc1 knockout evokes a depression-like phenotype in mice.";
RL   Behav. Brain Res. 296:7-14(2016).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=25503965; DOI=10.1038/ncomms6795;
RA   Pastor W.A., Stroud H., Nee K., Liu W., Pezic D., Manakov S., Lee S.A.,
RA   Moissiard G., Zamudio N., Bourc'his D., Aravin A.A., Clark A.T.,
RA   Jacobsen S.E.;
RT   "MORC1 represses transposable elements in the mouse male germline.";
RL   Nat. Commun. 5:5795-5795(2014).
CC   -!- FUNCTION: Required for spermatogenesis (PubMed:10369865,
CC       PubMed:25503965). Essential for de novo DNA methylation and silencing
CC       of transposable elements in the male embryonic germ cells
CC       (PubMed:25503965). Not required for piRNA biosynthesis
CC       (PubMed:25503965). {ECO:0000269|PubMed:10369865,
CC       ECO:0000269|PubMed:25503965}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10369865,
CC       ECO:0000269|PubMed:25503965}.
CC   -!- TISSUE SPECIFICITY: Expressed at very low level in male germ cells.
CC       {ECO:0000269|PubMed:10369865}.
CC   -!- DEVELOPMENTAL STAGE: Detected in embryonic testis at embryonic days
CC       14.5 dpc and peaks at 16.5 dpc. {ECO:0000269|PubMed:25503965}.
CC   -!- DISRUPTION PHENOTYPE: Mice show progressive loss of spermatogonia and
CC       male infertility (PubMed:10369865, PubMed:25503965). Spermatogenesis is
CC       blocked early in meiosis I (PubMed:10369865, PubMed:25503965). Male
CC       germ cells show derepression of transposable elements (TEs) and DNA
CC       hypomethylation of TEs (PubMed:25503965). Mice display increased
CC       depressive-like behavior whereas no behavioral abnormalities regarding
CC       locomotor activity or anxiety-like behavior are detectable and BDNF
CC       levels in the hippocampus are up-regulated (PubMed:26275923).
CC       {ECO:0000269|PubMed:10369865, ECO:0000269|PubMed:25503965,
CC       ECO:0000269|PubMed:26275923}.
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DR   EMBL; AF084945; AAD43003.1; -; mRNA.
DR   EMBL; BC030893; AAH30893.1; -; mRNA.
DR   CCDS; CCDS37351.1; -.
DR   RefSeq; NP_034946.1; NM_010816.1.
DR   AlphaFoldDB; Q9WVL5; -.
DR   SMR; Q9WVL5; -.
DR   STRING; 10090.ENSMUSP00000023330; -.
DR   iPTMnet; Q9WVL5; -.
DR   PhosphoSitePlus; Q9WVL5; -.
DR   PaxDb; Q9WVL5; -.
DR   PeptideAtlas; Q9WVL5; -.
DR   PRIDE; Q9WVL5; -.
DR   ProteomicsDB; 252592; -.
DR   Antibodypedia; 32406; 126 antibodies from 19 providers.
DR   DNASU; 17450; -.
DR   Ensembl; ENSMUST00000023330; ENSMUSP00000023330; ENSMUSG00000022652.
DR   GeneID; 17450; -.
DR   KEGG; mmu:17450; -.
DR   UCSC; uc007zjp.1; mouse.
DR   CTD; 27136; -.
DR   MGI; MGI:1316740; Morc1.
DR   VEuPathDB; HostDB:ENSMUSG00000022652; -.
DR   eggNOG; KOG1845; Eukaryota.
DR   GeneTree; ENSGT00940000153998; -.
DR   HOGENOM; CLU_011516_0_1_1; -.
DR   InParanoid; Q9WVL5; -.
DR   OMA; LDIWICA; -.
DR   OrthoDB; 193855at2759; -.
DR   PhylomeDB; Q9WVL5; -.
DR   TreeFam; TF329118; -.
DR   BioGRID-ORCS; 17450; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Morc1; mouse.
DR   PRO; PR:Q9WVL5; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q9WVL5; protein.
DR   Bgee; ENSMUSG00000022652; Expressed in otic capsule and 33 other tissues.
DR   Genevisible; Q9WVL5; MM.
DR   GO; GO:0001673; C:male germ cell nucleus; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0001662; P:behavioral fear response; IMP:MGI.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0044026; P:DNA hypermethylation; IMP:MGI.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; IMP:MGI.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:2000143; P:negative regulation of DNA-templated transcription, initiation; IMP:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
DR   GO; GO:0010529; P:negative regulation of transposition; IMP:MGI.
DR   GO; GO:0040029; P:regulation of gene expression, epigenetic; IMP:MGI.
DR   GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR   GO; GO:0032196; P:transposition; IMP:MGI.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR041006; Morc_S5.
DR   InterPro; IPR011124; Znf_CW.
DR   Pfam; PF17942; Morc6_S5; 1.
DR   Pfam; PF07496; zf-CW; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS51050; ZF_CW; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Differentiation; Metal-binding;
KW   Nucleus; Reference proteome; RNA-mediated gene silencing; Spermatogenesis;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..950
FT                   /note="MORC family CW-type zinc finger protein 1"
FT                   /id="PRO_0000248242"
FT   ZN_FING         465..530
FT                   /note="CW-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT   REGION          532..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          281..342
FT                   /evidence="ECO:0000255"
FT   COILED          885..916
FT                   /evidence="ECO:0000255"
FT   BINDING         485
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT   BINDING         488
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT   BINDING         511
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT   BINDING         522
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
SQ   SEQUENCE   950 AA;  108310 MW;  0DE2D3D30DB18F43 CRC64;
     MDKYALLQRA KLHLDFIHAN STTHSFLFGA LAELLDNARD AGAVRLDVFS VDNETLQGGF
     MLCFLDDGCG MSPDEASDVI YFGTSKKRLS TLKFIGQYGN GLKSGSMRIG KDCILFTKKE
     ETMTCLFFSQ TFCEKEGLTE VVVPIPSWLT RTRESITDDP QKFFTELSII FKYSPFKTEA
     ELMQQFDMIY GRCGTLLIIY NLKLLLSGEP ELDVTTDKED ILMAEAPEEI PERRSFRAYT
     AVLYFEPRMK IFIQAKRVQT KHLCYSLYKP RKYQYTTSSF KGKFKTEVQK AEEAVKRAEL
     LFKEVQAKVN QPDRIALSST QDALQKALQD VDTKHKSLRQ KQRALRKART LSLFFGVNTE
     DQHQAGMFIY SNNRLIKMYE KVGPQLKMKS LLGAGIIGIV NIPLETMEPS HNKQEFLNVQ
     EYNHLLKVMG QYLIQYCKDI GISNRNLTLF WDEFKYQHSK DTDSSLESLQ WRRRQAMGIP
     FILQCDLCLK WRVLPSSSNY QEKGLPDLWI CASNPNNLEN SCNQIERLPS IPLGTVNRRP
     PSKDERERQL QESVQRYQDK LVEAQPQKSQ LIVTSKIPEF KSSCLSSALK EKSKLGRIQP
     SGADLTQGSP SSVKLSFMQR SQKRSTEDTH SDVEFICMTK IPKKSVKKTV KYLQPGHAPA
     LLENLKLEDT AQVSSREIKK QQSESLVQAG KASTDVASSR DPTVTMVWDQ SSTKVSLKQE
     EEEEVPLIKP DKQELCDDTP VVKGNSSALH WKSLPGVQME DLSPRSGHKI NSVSGDCQLP
     ASPMPSQSMS VEETARKLLS NLREILLYFV PEFQLSSEFE CTSVEELITN PELERCPENI
     NEKLKTCFNQ IQNIYMAQYE KRLKRKMQSI VYEANRRGLL NQVFLGQCEL KRKRTEEKLS
     DLRAKLALLL QKLQLGGPAG DPQQIDAYLE DLLKEDRLPT ALHEKSPESA
 
 
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