MORC4_MOUSE
ID MORC4_MOUSE Reviewed; 928 AA.
AC Q8BMD7; A2RTG5; Q4KMM6; Q8BX95; Q9CS96;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=MORC family CW-type zinc finger protein 4;
DE AltName: Full=Zinc finger CW-type coiled-coil domain protein 2;
GN Name=Morc4; Synonyms=Zcwcc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-714 (ISOFORMS 1/2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Head, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=B5/EGFP; TISSUE=Brain, and Trophoblast stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Histone methylation reader which binds to non-methylated
CC (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and
CC trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The
CC order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0
CC (By similarity). {ECO:0000250|UniProtKB:Q8TE76}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TE76}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BMD7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BMD7-2; Sequence=VSP_015277, VSP_015278;
CC -!- DOMAIN: The CW-TYPE zinc finger mediates its binding to trimethylated
CC histone H3K4me3. {ECO:0000250|UniProtKB:Q8TE76}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH98483.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH98483.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAB30759.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK017472; BAB30759.1; ALT_INIT; mRNA.
DR EMBL; AK032807; BAC28032.1; -; mRNA.
DR EMBL; AK048519; BAC33356.1; -; mRNA.
DR EMBL; BC098483; AAH98483.1; ALT_SEQ; mRNA.
DR EMBL; BC132497; AAI32498.1; -; mRNA.
DR CCDS; CCDS53203.1; -. [Q8BMD7-2]
DR CCDS; CCDS57777.1; -. [Q8BMD7-1]
DR RefSeq; NP_001180238.1; NM_001193309.1. [Q8BMD7-1]
DR RefSeq; NP_083689.2; NM_029413.4. [Q8BMD7-2]
DR AlphaFoldDB; Q8BMD7; -.
DR SMR; Q8BMD7; -.
DR STRING; 10090.ENSMUSP00000033811; -.
DR iPTMnet; Q8BMD7; -.
DR PhosphoSitePlus; Q8BMD7; -.
DR PaxDb; Q8BMD7; -.
DR PRIDE; Q8BMD7; -.
DR ProteomicsDB; 291381; -. [Q8BMD7-1]
DR ProteomicsDB; 291382; -. [Q8BMD7-2]
DR Antibodypedia; 386; 31 antibodies from 11 providers.
DR Ensembl; ENSMUST00000033811; ENSMUSP00000033811; ENSMUSG00000031434. [Q8BMD7-2]
DR Ensembl; ENSMUST00000087401; ENSMUSP00000084663; ENSMUSG00000031434. [Q8BMD7-1]
DR GeneID; 75746; -.
DR KEGG; mmu:75746; -.
DR UCSC; uc009ukn.2; mouse. [Q8BMD7-1]
DR UCSC; uc009uko.2; mouse. [Q8BMD7-2]
DR CTD; 79710; -.
DR MGI; MGI:1922996; Morc4.
DR VEuPathDB; HostDB:ENSMUSG00000031434; -.
DR eggNOG; KOG1845; Eukaryota.
DR GeneTree; ENSGT00940000161221; -.
DR HOGENOM; CLU_011516_3_0_1; -.
DR InParanoid; Q8BMD7; -.
DR OMA; ENHQVFT; -.
DR OrthoDB; 193855at2759; -.
DR PhylomeDB; Q8BMD7; -.
DR TreeFam; TF329118; -.
DR BioGRID-ORCS; 75746; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Morc4; mouse.
DR PRO; PR:Q8BMD7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BMD7; protein.
DR Bgee; ENSMUSG00000031434; Expressed in yolk sac and 207 other tissues.
DR ExpressionAtlas; Q8BMD7; baseline and differential.
DR Genevisible; Q8BMD7; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0035064; F:methylated histone binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR045261; MORC_ATPase.
DR InterPro; IPR041006; Morc_S5.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR23336; PTHR23336; 1.
DR Pfam; PF17942; Morc6_S5; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..928
FT /note="MORC family CW-type zinc finger protein 4"
FT /id="PRO_0000096540"
FT ZN_FING 417..469
FT /note="CW-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT REGION 474..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 758..867
FT /evidence="ECO:0000255"
FT COMPBIAS 474..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 426
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 429
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 450
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT BINDING 461
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT VAR_SEQ 879..883
FT /note="ALARL -> LITRV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015277"
FT VAR_SEQ 884..928
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015278"
FT CONFLICT 221
FT /note="W -> C (in Ref. 1; BAC28032)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="F -> Y (in Ref. 1; BAB30759)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="K -> E (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="E -> K (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="L -> S (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
FT CONFLICT 690
FT /note="G -> D (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
FT CONFLICT 743
FT /note="C -> R (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
FT CONFLICT 750
FT /note="N -> S (in Ref. 2; AAH98483)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 928 AA; 105740 MW; 42F3D54527506628 CRC64;
MLLYRGAPAG PGTPGGGLAR AGSVPQAFRI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN
AVDPDVSART VFIDVEEVKK KPCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQRPIGV
FGNGFKSGSM RLGKDALVFT KNGNTLAVGL LSQTYLECIQ AQAVIVPIVP FSQQNKKMIV
TEDSLPSLEA ILNYSIFNCE KDLLSQFDAI PGKKGTRVLI WNIRRNKDGK SELDFDTDQY
DILVSDFDAE EKEIGGVTSE LPETEYSLRA FCSILYMKPR MKIFLRQKKV TTQMIAKSLA
NVEYDIYKPT STNKQVRITF GFSCKYHNQF GVMMYHNNRL IKAFEKAGCQ LKPTCGEGVG
VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALARKLNAYW KEKISQENFE PLPTSRRIPD
QTWVQCDECL KWRRLPGMVD PSTLPARWFC YYNPHPKFKR CSVPEEQERI DEDLHRSKAK
QQVEAAEKKQ KPMESDKYQV FSNPPKTPPL QDMAELNDKT IGYEQINSPS LLPSVREESR
SPPRLKSLDS SAFQISRKYK LILGEEPVEK RRKIQTEMPL SPIDYSMSGF YRRVEAATAY
PEGENSPDKC SSERSTPPHL IPEYPESNKH TEENREAPAL CPGSQDQDQG FLLPEELEDQ
MPKLVAEESN RSSENIDKDM NKGPFVAVVG VAKGVADSGA PIQLVPFNRE EFVGKRKRAE
SWKRANPYSS AAPAATAGKG KDCQDSRSRN MPKIKTPKES EELKRTTEKL ERVLAERNLF
QQKVEELEQE KNHWHSEYKK AQHELVTYST QETEGIYWSK KHMGYRQAEF QILKAELERT
KEEKQELKEK LKETESHLEV LQKAQVSFRN PEGDDLERAL ARLTRLRVHV SYLLTSVLPH
LELREIGYDS EQVDGILYTV LEANHILD
