MORF5_ARATH
ID MORF5_ARATH Reviewed; 229 AA.
AC Q9C7Y2;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Multiple organellar RNA editing factor 5, chloroplastic/mitochondrial {ECO:0000305};
DE AltName: Full=RNA editing-interacting protein 5 {ECO:0000303|PubMed:23818871};
DE Flags: Precursor;
GN Name=MORF5 {ECO:0000303|PubMed:22411807};
GN Synonyms=RIP5 {ECO:0000303|PubMed:23818871};
GN OrderedLocusNames=At1g32580 {ECO:0000312|Araport:AT1G32580};
GN ORFNames=T9G5.3 {ECO:0000312|EMBL:AAG51246.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22411807; DOI=10.1073/pnas.1202452109;
RA Takenaka M., Zehrmann A., Verbitskiy D., Kugelmann M., Hartel B.,
RA Brennicke A.;
RT "Multiple organellar RNA editing factor (MORF) family proteins are required
RT for RNA editing in mitochondria and plastids of plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5104-5109(2012).
RN [5]
RP FUNCTION, GENE FAMILY, AND DISRUPTION PHENOTYPE.
RX PubMed=23818871; DOI=10.1371/journal.pgen.1003584;
RA Bentolila S., Oh J., Hanson M.R., Bukowski R.;
RT "Comprehensive high-resolution analysis of the role of an Arabidopsis gene
RT family in RNA editing.";
RL PLoS Genet. 9:E1003584-E1003584(2013).
RN [6]
RP HOMODIMERIZATION, INTERACTION WITH MORF8/RIP1; MORF3/RIP3; MORF6/RIP6;
RP MORF7/RIP7 AND MORF9/RIP9, AND SUBCELLULAR LOCATION.
RX PubMed=25583991; DOI=10.1074/jbc.m114.602086;
RA Zehrmann A., Haertel B., Glass F., Bayer-Csaszar E., Obata T., Meyer E.,
RA Brennicke A., Takenaka M.;
RT "Selective homo- and heteromer interactions between the multiple organellar
RT RNA editing factor (MORF) proteins in Arabidopsis thaliana.";
RL J. Biol. Chem. 290:6445-6456(2015).
CC -!- FUNCTION: Involved in organellar RNA editing. Required for the
CC processing of few RNA editing sites in mitochondria.
CC {ECO:0000269|PubMed:23818871}.
CC -!- SUBUNIT: Homodimer and heterodimers with MORF8/RIP1, MORF3/RIP3,
CC MORF6/RIP6, MORF7/RIP7 and MORF9/RIP9. {ECO:0000269|PubMed:25583991}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25583991}.
CC Plastid, chloroplast {ECO:0000269|PubMed:25583991}. Note=Dual targeting
CC to mitochondria and chloroplasts. {ECO:0000269|PubMed:25583991}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:23818871}.
CC -!- SIMILARITY: Belongs to the MORF family.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC055769; AAG51246.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31506.1; -; Genomic_DNA.
DR EMBL; AY063995; AAL36351.1; -; mRNA.
DR EMBL; AY096695; AAM20329.1; -; mRNA.
DR PIR; D86451; D86451.
DR RefSeq; NP_174536.1; NM_102993.4.
DR AlphaFoldDB; Q9C7Y2; -.
DR SMR; Q9C7Y2; -.
DR IntAct; Q9C7Y2; 4.
DR STRING; 3702.AT1G32580.1; -.
DR PaxDb; Q9C7Y2; -.
DR PRIDE; Q9C7Y2; -.
DR ProteomicsDB; 250937; -.
DR EnsemblPlants; AT1G32580.1; AT1G32580.1; AT1G32580.
DR GeneID; 840152; -.
DR Gramene; AT1G32580.1; AT1G32580.1; AT1G32580.
DR KEGG; ath:AT1G32580; -.
DR Araport; AT1G32580; -.
DR TAIR; locus:2206639; AT1G32580.
DR eggNOG; ENOG502QPXC; Eukaryota.
DR HOGENOM; CLU_073703_1_0_1; -.
DR InParanoid; Q9C7Y2; -.
DR OMA; TERYYGF; -.
DR OrthoDB; 1287972at2759; -.
DR PhylomeDB; Q9C7Y2; -.
DR PRO; PR:Q9C7Y2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C7Y2; baseline and differential.
DR Genevisible; Q9C7Y2; AT.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IPI:TAIR.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR GO; GO:0016554; P:cytidine to uridine editing; IEA:InterPro.
DR GO; GO:0080156; P:mitochondrial mRNA modification; IMP:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.80; -; 1.
DR InterPro; IPR039206; MORF/ORRM1/DAG-like.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR31346; PTHR31346; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Mitochondrion; mRNA processing; Plastid; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..57
FT /note="Chloroplast and mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 58..229
FT /note="Multiple organellar RNA editing factor 5,
FT chloroplastic/mitochondrial"
FT /id="PRO_0000432528"
SQ SEQUENCE 229 AA; 26025 MW; 0D7F2B488345AEFD CRC64;
MAKTLARSTA SRITKRLIST SGATTPSPSY ILSRRSTPVF SHAVGFISSL NRFTTIRTRM
DRSGGSYSPL KSGSNFSDRA PTEMAPLFPG CDYEHWLIVM DKPGGENATK QQMIDCYVQT
LAKIIGSEEE AKKKIYNVSC ERYFGFGCEI DEETSNKLEG LPGVLFILPD SYVDQENKDY
GAELFVNGEI VQRPPERQRK IIELTTQRTN DKPKYHDKTR YVRRRENMR
