MORF6_ARATH
ID MORF6_ARATH Reviewed; 232 AA.
AC O82169;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Multiple organellar RNA editing factor 6, mitochondrial {ECO:0000305};
DE AltName: Full=RNA editing-interacting protein 6 {ECO:0000303|PubMed:23818871};
DE Flags: Precursor;
GN Name=MORF6 {ECO:0000303|PubMed:22411807};
GN Synonyms=RIP6 {ECO:0000303|PubMed:23818871};
GN OrderedLocusNames=At2g35240 {ECO:0000312|Araport:AT2G35240};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22411807; DOI=10.1073/pnas.1202452109;
RA Takenaka M., Zehrmann A., Verbitskiy D., Kugelmann M., Hartel B.,
RA Brennicke A.;
RT "Multiple organellar RNA editing factor (MORF) family proteins are required
RT for RNA editing in mitochondria and plastids of plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5104-5109(2012).
RN [5]
RP GENE FAMILY.
RX PubMed=23818871; DOI=10.1371/journal.pgen.1003584;
RA Bentolila S., Oh J., Hanson M.R., Bukowski R.;
RT "Comprehensive high-resolution analysis of the role of an Arabidopsis gene
RT family in RNA editing.";
RL PLoS Genet. 9:E1003584-E1003584(2013).
RN [6]
RP INTERACTION WITH MORF8/RIP1; MORF1/RIP8; MORF5/RIP5 AND MORF7/RIP7, AND
RP SUBCELLULAR LOCATION.
RX PubMed=25583991; DOI=10.1074/jbc.m114.602086;
RA Zehrmann A., Haertel B., Glass F., Bayer-Csaszar E., Obata T., Meyer E.,
RA Brennicke A., Takenaka M.;
RT "Selective homo- and heteromer interactions between the multiple organellar
RT RNA editing factor (MORF) proteins in Arabidopsis thaliana.";
RL J. Biol. Chem. 290:6445-6456(2015).
CC -!- FUNCTION: Involved in organellar RNA editing. Required for the
CC processing of few RNA editing sites in mitochondria.
CC {ECO:0000269|PubMed:22411807, ECO:0000269|PubMed:23818871}.
CC -!- SUBUNIT: Heterodimers with MORF8/RIP1, MORF3/RIP3, MORF6/RIP6,
CC MORF7/RIP7 and MORF9/RIP9. {ECO:0000269|PubMed:25583991}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25583991}.
CC -!- SIMILARITY: Belongs to the MORF family.
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DR EMBL; AC004667; AAC61814.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09085.1; -; Genomic_DNA.
DR EMBL; AY072439; AAL62431.1; -; mRNA.
DR EMBL; BT003414; AAO30077.1; -; mRNA.
DR PIR; B84766; B84766.
DR RefSeq; NP_181067.1; NM_129076.4.
DR AlphaFoldDB; O82169; -.
DR SMR; O82169; -.
DR IntAct; O82169; 4.
DR STRING; 3702.AT2G35240.1; -.
DR PaxDb; O82169; -.
DR PRIDE; O82169; -.
DR ProteomicsDB; 238305; -.
DR EnsemblPlants; AT2G35240.1; AT2G35240.1; AT2G35240.
DR GeneID; 818091; -.
DR Gramene; AT2G35240.1; AT2G35240.1; AT2G35240.
DR KEGG; ath:AT2G35240; -.
DR Araport; AT2G35240; -.
DR TAIR; locus:2063389; AT2G35240.
DR eggNOG; ENOG502QPXC; Eukaryota.
DR HOGENOM; CLU_073703_1_0_1; -.
DR InParanoid; O82169; -.
DR OMA; HLISRRF; -.
DR OrthoDB; 1287972at2759; -.
DR PhylomeDB; O82169; -.
DR PRO; PR:O82169; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O82169; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IPI:TAIR.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR GO; GO:0016554; P:cytidine to uridine editing; IEA:InterPro.
DR GO; GO:0080156; P:mitochondrial mRNA modification; IMP:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.80; -; 1.
DR InterPro; IPR039206; MORF/ORRM1/DAG-like.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR31346; PTHR31346; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; mRNA processing; Reference proteome; Transit peptide.
FT TRANSIT 1..67
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 68..232
FT /note="Multiple organellar RNA editing factor 6,
FT mitochondrial"
FT /id="PRO_0000432529"
FT REGION 208..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 232 AA; 26368 MW; EDB72A417F084B20 CRC64;
MAKTLSRSTA SCVAKRFFST SNAVASPSPL PSHLISRRFS PTIFHAVGYI PALTRFTTIR
TRMDRSGGSY SPLKSGSNFS DRPPTEMAPL FPGCDYEHWL IVMEKPGGEN AQKQQMIDCY
VQTLAKIVGS EEEARKKIYN VSCERYFGFG CEIDEETSNK LEGLPGVLFV LPDSYVDPEF
KDYGAELFVN GEVVPRPPER QRRMVELTNQ RGSDKPKYHD RIRNVRRREN MR
