MORF7_ARATH
ID MORF7_ARATH Reviewed; 188 AA.
AC Q9CAH0;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Multiple organellar RNA editing factor 7, mitochondrial {ECO:0000305};
DE AltName: Full=RNA editing-interacting protein 7 {ECO:0000303|PubMed:23818871};
DE Flags: Precursor;
GN Name=MORF7 {ECO:0000303|PubMed:22411807};
GN Synonyms=RIP7 {ECO:0000303|PubMed:23818871};
GN OrderedLocusNames=At1g72530 {ECO:0000312|Araport:AT1G72530};
GN ORFNames=F28P22.28 {ECO:0000312|EMBL:AAG51843.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22411807; DOI=10.1073/pnas.1202452109;
RA Takenaka M., Zehrmann A., Verbitskiy D., Kugelmann M., Hartel B.,
RA Brennicke A.;
RT "Multiple organellar RNA editing factor (MORF) family proteins are required
RT for RNA editing in mitochondria and plastids of plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5104-5109(2012).
RN [5]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=23818871; DOI=10.1371/journal.pgen.1003584;
RA Bentolila S., Oh J., Hanson M.R., Bukowski R.;
RT "Comprehensive high-resolution analysis of the role of an Arabidopsis gene
RT family in RNA editing.";
RL PLoS Genet. 9:E1003584-E1003584(2013).
RN [6]
RP INTERACTION WITH MORF8/RIP1; MORF5/RIP5 AND MORF6/RIP6, AND SUBCELLULAR
RP LOCATION.
RX PubMed=25583991; DOI=10.1074/jbc.m114.602086;
RA Zehrmann A., Haertel B., Glass F., Bayer-Csaszar E., Obata T., Meyer E.,
RA Brennicke A., Takenaka M.;
RT "Selective homo- and heteromer interactions between the multiple organellar
RT RNA editing factor (MORF) proteins in Arabidopsis thaliana.";
RL J. Biol. Chem. 290:6445-6456(2015).
CC -!- FUNCTION: Involved in organellar RNA editing. Required for the
CC processing of few RNA editing sites in mitochondria.
CC {ECO:0000269|PubMed:23818871}.
CC -!- SUBUNIT: Heterodimers with MORF8/RIP1, MORF5/RIP5 and MORF6/RIP6.
CC {ECO:0000269|PubMed:25583991}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25583991}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=Q9CAH0-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the MORF family.
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DR EMBL; AC010926; AAG51843.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35335.1; -; Genomic_DNA.
DR EMBL; BT030079; ABN04817.1; -; mRNA.
DR PIR; F96749; F96749.
DR RefSeq; NP_177397.1; NM_105912.2. [Q9CAH0-1]
DR AlphaFoldDB; Q9CAH0; -.
DR SMR; Q9CAH0; -.
DR STRING; 3702.AT1G72530.2; -.
DR PaxDb; Q9CAH0; -.
DR PRIDE; Q9CAH0; -.
DR DNASU; 843585; -.
DR EnsemblPlants; AT1G72530.1; AT1G72530.1; AT1G72530. [Q9CAH0-1]
DR GeneID; 843585; -.
DR Gramene; AT1G72530.1; AT1G72530.1; AT1G72530. [Q9CAH0-1]
DR KEGG; ath:AT1G72530; -.
DR Araport; AT1G72530; -.
DR eggNOG; ENOG502S1UF; Eukaryota.
DR PhylomeDB; Q9CAH0; -.
DR PRO; PR:Q9CAH0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9CAH0; baseline and differential.
DR Genevisible; Q9CAH0; AT.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0016554; P:cytidine to uridine editing; IEA:InterPro.
DR GO; GO:0080156; P:mitochondrial mRNA modification; IMP:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR039206; MORF/ORRM1/DAG-like.
DR PANTHER; PTHR31346; PTHR31346; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; mRNA processing; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..20
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 21..188
FT /note="Multiple organellar RNA editing factor 7,
FT mitochondrial"
FT /evidence="ECO:0000255"
FT /id="PRO_0000432530"
FT REGION 169..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 21623 MW; 52AE7A23448BB828 CRC64;
MARIIRRPLN LTAAVRFRLS PLSPFSGNSG SINSETTSWS ELIRVPSLVE GCDYKHWLVL
MKPPNGYPTR NHIVQSFVET LAMALGSEEE AKRSIYSVST KYYYAFGCRI HEPLTYKIRS
LPDVKWVLPD SFIVDGDNRY GGEPFVDGEV VPYDEKYHAD WLRDQTDEDA KSGVVKKKHR
RKRKKKLI
