MORN1_HUMAN
ID MORN1_HUMAN Reviewed; 497 AA.
AC Q5T089; A6NKZ6; Q8WW30; Q9H852;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=MORN repeat-containing protein 1;
GN Name=MORN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Retinoblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT TYR-330.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T089-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T089-2; Sequence=VSP_019994, VSP_019995;
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DR EMBL; AK024003; BAB14768.1; -; mRNA.
DR EMBL; AL589739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL513477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021704; AAH21704.1; -; mRNA.
DR CCDS; CCDS40.1; -. [Q5T089-1]
DR CCDS; CCDS72688.1; -. [Q5T089-2]
DR RefSeq; NP_001287989.1; NM_001301060.1. [Q5T089-2]
DR RefSeq; NP_079124.1; NM_024848.2. [Q5T089-1]
DR AlphaFoldDB; Q5T089; -.
DR SMR; Q5T089; -.
DR BioGRID; 122989; 3.
DR IntAct; Q5T089; 4.
DR STRING; 9606.ENSP00000367792; -.
DR iPTMnet; Q5T089; -.
DR PhosphoSitePlus; Q5T089; -.
DR BioMuta; MORN1; -.
DR DMDM; 110810454; -.
DR EPD; Q5T089; -.
DR MassIVE; Q5T089; -.
DR PaxDb; Q5T089; -.
DR PeptideAtlas; Q5T089; -.
DR PRIDE; Q5T089; -.
DR ProteomicsDB; 64135; -. [Q5T089-1]
DR ProteomicsDB; 64136; -. [Q5T089-2]
DR Antibodypedia; 1621; 84 antibodies from 18 providers.
DR DNASU; 79906; -.
DR Ensembl; ENST00000378529.7; ENSP00000367790.3; ENSG00000116151.14. [Q5T089-2]
DR Ensembl; ENST00000378531.8; ENSP00000367792.3; ENSG00000116151.14. [Q5T089-1]
DR GeneID; 79906; -.
DR KEGG; hsa:79906; -.
DR MANE-Select; ENST00000378531.8; ENSP00000367792.3; NM_024848.3; NP_079124.1.
DR UCSC; uc001ajb.2; human. [Q5T089-1]
DR CTD; 79906; -.
DR DisGeNET; 79906; -.
DR GeneCards; MORN1; -.
DR HGNC; HGNC:25852; MORN1.
DR HPA; ENSG00000116151; Low tissue specificity.
DR neXtProt; NX_Q5T089; -.
DR OpenTargets; ENSG00000116151; -.
DR PharmGKB; PA142671342; -.
DR VEuPathDB; HostDB:ENSG00000116151; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000161806; -.
DR HOGENOM; CLU_031327_0_0_1; -.
DR InParanoid; Q5T089; -.
DR OMA; GEYVIMI; -.
DR OrthoDB; 1309439at2759; -.
DR PhylomeDB; Q5T089; -.
DR TreeFam; TF329558; -.
DR PathwayCommons; Q5T089; -.
DR SignaLink; Q5T089; -.
DR BioGRID-ORCS; 79906; 15 hits in 1065 CRISPR screens.
DR ChiTaRS; MORN1; human.
DR GeneWiki; Morn_repeat_containing_1; -.
DR GenomeRNAi; 79906; -.
DR Pharos; Q5T089; Tbio.
DR PRO; PR:Q5T089; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T089; protein.
DR Bgee; ENSG00000116151; Expressed in right uterine tube and 129 other tissues.
DR ExpressionAtlas; Q5T089; baseline and differential.
DR Genevisible; Q5T089; HS.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 8.
DR SMART; SM00698; MORN; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..497
FT /note="MORN repeat-containing protein 1"
FT /id="PRO_0000247454"
FT REPEAT 39..61
FT /note="MORN 1"
FT REPEAT 62..84
FT /note="MORN 2"
FT REPEAT 86..108
FT /note="MORN 3"
FT REPEAT 109..131
FT /note="MORN 4"
FT REPEAT 132..154
FT /note="MORN 5"
FT REPEAT 155..177
FT /note="MORN 6"
FT REPEAT 178..200
FT /note="MORN 7"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 346..350
FT /note="ARGHA -> GSSLF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019994"
FT VAR_SEQ 351..497
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019995"
FT VARIANT 124
FT /note="L -> V (in dbSNP:rs12130128)"
FT /id="VAR_051199"
FT VARIANT 330
FT /note="H -> Y (in dbSNP:rs17851912)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027105"
SQ SEQUENCE 497 AA; 53850 MW; 92A70E3880FABF62 CRC64;
MAAAGEGTPS SRGPRRDPPR RPPRNGYGVY VYPNSFFRYE GEWKAGRKHG HGKLLFKDGS
YYEGAFVDGE ITGEGRRHWA WSGDTFSGQF VLGEPQGYGV MEYKAGGCYE GEVSHGMREG
HGFLVDRDGQ VYQGSFHDNK RHGPGQMLFQ NGDKYDGDWV RDRRQGHGVL RCADGSTYKG
QWHSDVFSGL GSMAHCSGVT YYGLWINGHP AEQATRIVIL GPEVMEVAQG SPFSVNVQLL
QDHGEIAKSE SGRVLQISAG VRYVQLSAYS EVNFFKVDRD NQETLIQTPF GFECIPYPVS
SPAAGVPGPR AAKGGAEADV PLPRGDLELH LGALHGQEDT PGGLLARGHA PHCPGACQRV
EQGCAEFTDV LLGPPPPGYH PFLFLDSLHK KAGGRSRGGL HPRGTPPTAQ EPPGGSRPEG
RATEEQAAAA HLGEYVLMIR DVTTPPFLGR RLPPAFKHLR VVAKRAGQPP HVLEEGPEAS
SSWQAAHSCT PEPPAPR
