ID   MORN2_HUMAN             Reviewed;          79 AA.
AC   Q502X0; Q6UL00;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=MORN repeat-containing protein 2 {ECO:0000312|HGNC:HGNC:30166};
DE   AltName: Full=MORN motif protein in testis {ECO:0000303|PubMed:19913896};
GN   Name=MORN2 {ECO:0000312|HGNC:HGNC:30166};
GN   Synonyms=MOPT {ECO:0000303|PubMed:19913896};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAQ73170.1};
RX   PubMed=19913896; DOI=10.1016/j.theriogenology.2009.09.010;
RA   Choi Y.J., Hwang K.C., Park J.Y., Park K.K., Kim J.H., Park S.B., Hwang S.,
RA   Park H., Park C., Kim J.H.;
RT   "Identification and characterization of a novel mouse and human MOPT gene
RT   containing MORN-motif protein in testis.";
RL   Theriogenology 73:273-281(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-48.
RC   TISSUE=Chondrosarcoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Might have a role in spermatogenesis.
CC       {ECO:0000250|UniProtKB:Q6UL01}.
CC   -!- INTERACTION:
CC       Q502X0; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-725982, EBI-739467;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q6UL01}. Nucleus {ECO:0000250|UniProtKB:Q6UL01}.
CC       Note=Associated with the acrosome during post-meiotic stages of
CC       spermatogenesis. Appears to migrate to the nucleus during the final
CC       step of spermiogenesis. {ECO:0000250|UniProtKB:Q6UL01}.
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DR   EMBL; AY367766; AAQ73170.1; -; mRNA.
DR   EMBL; BC095472; AAH95472.1; -; mRNA.
DR   EMBL; BC102032; AAI02033.1; -; mRNA.
DR   EMBL; BC102034; AAI02035.1; -; mRNA.
DR   EMBL; BC102035; AAI02036.1; -; mRNA.
DR   RefSeq; NP_001138922.1; NM_001145450.1.
DR   AlphaFoldDB; Q502X0; -.
DR   SMR; Q502X0; -.
DR   BioGRID; 610358; 4.
DR   IntAct; Q502X0; 4.
DR   STRING; 9606.ENSP00000386563; -.
DR   iPTMnet; Q502X0; -.
DR   PhosphoSitePlus; Q502X0; -.
DR   BioMuta; MORN2; -.
DR   DMDM; 110810457; -.
DR   MassIVE; Q502X0; -.
DR   MaxQB; Q502X0; -.
DR   PaxDb; Q502X0; -.
DR   PeptideAtlas; Q502X0; -.
DR   PRIDE; Q502X0; -.
DR   ProteomicsDB; 62399; -.
DR   Antibodypedia; 71693; 28 antibodies from 7 providers.
DR   DNASU; 729967; -.
DR   Ensembl; ENST00000409665.5; ENSP00000386874.1; ENSG00000188010.16.
DR   Ensembl; ENST00000410014.5; ENSP00000386563.1; ENSG00000188010.16.
DR   GeneID; 729967; -.
DR   KEGG; hsa:729967; -.
DR   UCSC; uc010fak.3; human.
DR   CTD; 729967; -.
DR   DisGeNET; 729967; -.
DR   GeneCards; MORN2; -.
DR   HGNC; HGNC:30166; MORN2.
DR   HPA; ENSG00000188010; Tissue enhanced (testis).
DR   neXtProt; NX_Q502X0; -.
DR   OpenTargets; ENSG00000188010; -.
DR   PharmGKB; PA142671343; -.
DR   VEuPathDB; HostDB:ENSG00000188010; -.
DR   eggNOG; ENOG502S53V; Eukaryota.
DR   GeneTree; ENSGT00390000006619; -.
DR   HOGENOM; CLU_032017_5_5_1; -.
DR   InParanoid; Q502X0; -.
DR   OMA; WHEDKMH; -.
DR   OrthoDB; 1422903at2759; -.
DR   PhylomeDB; Q502X0; -.
DR   TreeFam; TF352715; -.
DR   PathwayCommons; Q502X0; -.
DR   SignaLink; Q502X0; -.
DR   BioGRID-ORCS; 729967; 20 hits in 1074 CRISPR screens.
DR   ChiTaRS; MORN2; human.
DR   GenomeRNAi; 729967; -.
DR   Pharos; Q502X0; Tdark.
DR   PRO; PR:Q502X0; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q502X0; protein.
DR   Bgee; ENSG00000188010; Expressed in left testis and 166 other tissues.
DR   ExpressionAtlas; Q502X0; baseline and differential.
DR   Genevisible; Q502X0; HS.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR003409; MORN.
DR   Pfam; PF02493; MORN; 2.
DR   SMART; SM00698; MORN; 2.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Differentiation; Nucleus; Reference proteome; Repeat;
KW   Spermatogenesis.
FT   CHAIN           1..79
FT                   /note="MORN repeat-containing protein 2"
FT                   /id="PRO_0000247457"
FT   REPEAT          15..36
FT                   /note="MORN 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          38..55
FT                   /note="MORN 2"
FT                   /evidence="ECO:0000255"
FT   VARIANT         48
FT                   /note="E -> K (in dbSNP:rs3099950)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_027106"
SQ   SEQUENCE   79 AA;  8939 MW;  93D0A55736E956FA CRC64;
     MNGFGRLEHF SGAVYEGQFK DNMFHGLGTY TFPNGAKYTG NFNENRVEGE GEYTDIQGLE
     WSGNFHFTAA PDLKLKLHM