MORN2_MOUSE
ID MORN2_MOUSE Reviewed; 79 AA.
AC Q6UL01;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=MORN repeat-containing protein 2 {ECO:0000312|MGI:MGI:2674071};
DE AltName: Full=MORN motif protein in testis {ECO:0000303|PubMed:19913896};
GN Name=Morn2 {ECO:0000312|MGI:MGI:2674071};
GN Synonyms=Mopt {ECO:0000303|PubMed:19913896};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Testis {ECO:0000312|EMBL:AAQ73169.1};
RX PubMed=19913896; DOI=10.1016/j.theriogenology.2009.09.010;
RA Choi Y.J., Hwang K.C., Park J.Y., Park K.K., Kim J.H., Park S.B., Hwang S.,
RA Park H., Park C., Kim J.H.;
RT "Identification and characterization of a novel mouse and human MOPT gene
RT containing MORN-motif protein in testis.";
RL Theriogenology 73:273-281(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Might have a role in spermatogenesis.
CC {ECO:0000305|PubMed:19913896}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:19913896}. Nucleus {ECO:0000269|PubMed:19913896}.
CC Note=Associated with the acrosome during post-meiotic stages of
CC spermatogenesis. Appears to migrate to the nucleus during the final
CC step of spermiogenesis. {ECO:0000269|PubMed:19913896}.
CC -!- TISSUE SPECIFICITY: Expressed strongly in testis, where it is
CC specifically detected in haploid germ cells (at protein level). Also
CC expressed strongly in skeletal muscle. {ECO:0000269|PubMed:19913896}.
CC -!- DEVELOPMENTAL STAGE: Detected from postnatal day 15 onwards, with high
CC levels of expression by postnatal day 28.
CC {ECO:0000269|PubMed:19913896}.
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DR EMBL; AY367765; AAQ73169.1; -; mRNA.
DR EMBL; BC089486; AAH89486.1; -; mRNA.
DR CCDS; CCDS37703.1; -.
DR RefSeq; NP_919245.1; NM_194269.2.
DR RefSeq; XP_006524520.1; XM_006524457.1.
DR RefSeq; XP_011244809.1; XM_011246507.1.
DR AlphaFoldDB; Q6UL01; -.
DR SMR; Q6UL01; -.
DR BioGRID; 237547; 1.
DR IntAct; Q6UL01; 1.
DR STRING; 10090.ENSMUSP00000051408; -.
DR PhosphoSitePlus; Q6UL01; -.
DR PaxDb; Q6UL01; -.
DR PRIDE; Q6UL01; -.
DR ProteomicsDB; 290276; -.
DR Antibodypedia; 71693; 28 antibodies from 7 providers.
DR DNASU; 378462; -.
DR Ensembl; ENSMUST00000061703; ENSMUSP00000051408; ENSMUSG00000045257.
DR GeneID; 378462; -.
DR KEGG; mmu:378462; -.
DR UCSC; uc008drd.2; mouse.
DR CTD; 729967; -.
DR MGI; MGI:2674071; Morn2.
DR VEuPathDB; HostDB:ENSMUSG00000045257; -.
DR eggNOG; ENOG502S53V; Eukaryota.
DR GeneTree; ENSGT00390000006619; -.
DR HOGENOM; CLU_032017_5_5_1; -.
DR InParanoid; Q6UL01; -.
DR OMA; WHEDKMH; -.
DR OrthoDB; 1422903at2759; -.
DR PhylomeDB; Q6UL01; -.
DR TreeFam; TF352715; -.
DR BioGRID-ORCS; 378462; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Morn2; mouse.
DR PRO; PR:Q6UL01; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6UL01; protein.
DR Bgee; ENSMUSG00000045257; Expressed in seminiferous tubule of testis and 216 other tissues.
DR ExpressionAtlas; Q6UL01; baseline and differential.
DR Genevisible; Q6UL01; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 2.
DR SMART; SM00698; MORN; 2.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Differentiation; Nucleus; Reference proteome; Repeat;
KW Spermatogenesis.
FT CHAIN 1..79
FT /note="MORN repeat-containing protein 2"
FT /id="PRO_0000247458"
FT REPEAT 15..36
FT /note="MORN 1"
FT /evidence="ECO:0000255"
FT REPEAT 38..58
FT /note="MORN 2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 79 AA; 8897 MW; 317AA24DEC346A1E CRC64;
MNGFGRLEHF SGAVYEGQFK DNMFHGLGTY TFPTGAKYTG NFNENRVEGE GEYTDTQGLQ
WCGNFHFTAA PGLKLKLYM
