MORN3_HUMAN
ID MORN3_HUMAN Reviewed; 240 AA.
AC Q6PF18; Q86YQ9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=MORN repeat-containing protein 3;
GN Name=MORN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Mao Y., Xie Y., Wu H.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6PF18; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-9675802, EBI-12318443;
CC Q6PF18; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-9675802, EBI-10173507;
CC Q6PF18; Q03989: ARID5A; NbExp=3; IntAct=EBI-9675802, EBI-948603;
CC Q6PF18; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-9675802, EBI-745073;
CC Q6PF18; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-9675802, EBI-2548012;
CC Q6PF18; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-9675802, EBI-725606;
CC Q6PF18; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-9675802, EBI-5278764;
CC Q6PF18; Q9GZU7: CTDSP1; NbExp=3; IntAct=EBI-9675802, EBI-751587;
CC Q6PF18; P63167: DYNLL1; NbExp=3; IntAct=EBI-9675802, EBI-349105;
CC Q6PF18; Q96FJ2: DYNLL2; NbExp=4; IntAct=EBI-9675802, EBI-742371;
CC Q6PF18; O15371: EIF3D; NbExp=3; IntAct=EBI-9675802, EBI-353818;
CC Q6PF18; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-9675802, EBI-744099;
CC Q6PF18; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-9675802, EBI-12160437;
CC Q6PF18; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-9675802, EBI-6658203;
CC Q6PF18; Q9NW38: FANCL; NbExp=3; IntAct=EBI-9675802, EBI-2339898;
CC Q6PF18; O95363: FARS2; NbExp=3; IntAct=EBI-9675802, EBI-2513774;
CC Q6PF18; Q9C0B1-2: FTO; NbExp=3; IntAct=EBI-9675802, EBI-18138793;
CC Q6PF18; P55040: GEM; NbExp=3; IntAct=EBI-9675802, EBI-744104;
CC Q6PF18; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-9675802, EBI-748515;
CC Q6PF18; Q08379: GOLGA2; NbExp=8; IntAct=EBI-9675802, EBI-618309;
CC Q6PF18; O95872: GPANK1; NbExp=3; IntAct=EBI-9675802, EBI-751540;
CC Q6PF18; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-9675802, EBI-11978177;
CC Q6PF18; Q9BQA5: HINFP; NbExp=3; IntAct=EBI-9675802, EBI-749065;
CC Q6PF18; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-9675802, EBI-10961706;
CC Q6PF18; P14652: HOXB2; NbExp=3; IntAct=EBI-9675802, EBI-5329558;
CC Q6PF18; Q9UKT9: IKZF3; NbExp=7; IntAct=EBI-9675802, EBI-747204;
CC Q6PF18; Q9C086: INO80B; NbExp=3; IntAct=EBI-9675802, EBI-715611;
CC Q6PF18; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-9675802, EBI-2556193;
CC Q6PF18; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-9675802, EBI-6426443;
CC Q6PF18; P19012: KRT15; NbExp=3; IntAct=EBI-9675802, EBI-739566;
CC Q6PF18; P50458: LHX2; NbExp=3; IntAct=EBI-9675802, EBI-12179869;
CC Q6PF18; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-9675802, EBI-741037;
CC Q6PF18; P43360: MAGEA6; NbExp=6; IntAct=EBI-9675802, EBI-1045155;
CC Q6PF18; Q8IYB1: MB21D2; NbExp=3; IntAct=EBI-9675802, EBI-11323212;
CC Q6PF18; P50222: MEOX2; NbExp=3; IntAct=EBI-9675802, EBI-748397;
CC Q6PF18; Q8IVT2: MISP; NbExp=3; IntAct=EBI-9675802, EBI-2555085;
CC Q6PF18; Q13064: MKRN3; NbExp=3; IntAct=EBI-9675802, EBI-2340269;
CC Q6PF18; P40692: MLH1; NbExp=3; IntAct=EBI-9675802, EBI-744248;
CC Q6PF18; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-9675802, EBI-5662487;
CC Q6PF18; O14561: NDUFAB1; NbExp=3; IntAct=EBI-9675802, EBI-1246261;
CC Q6PF18; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-9675802, EBI-725252;
CC Q6PF18; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-9675802, EBI-12025760;
CC Q6PF18; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-9675802, EBI-741158;
CC Q6PF18; O43482: OIP5; NbExp=3; IntAct=EBI-9675802, EBI-536879;
CC Q6PF18; P26367: PAX6; NbExp=3; IntAct=EBI-9675802, EBI-747278;
CC Q6PF18; O43189: PHF1; NbExp=3; IntAct=EBI-9675802, EBI-530034;
CC Q6PF18; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-9675802, EBI-79165;
CC Q6PF18; O15160: POLR1C; NbExp=3; IntAct=EBI-9675802, EBI-1055079;
CC Q6PF18; P54646: PRKAA2; NbExp=3; IntAct=EBI-9675802, EBI-1383852;
CC Q6PF18; O43741: PRKAB2; NbExp=3; IntAct=EBI-9675802, EBI-1053424;
CC Q6PF18; Q6MZQ0: PRR5L; NbExp=3; IntAct=EBI-9675802, EBI-1567866;
CC Q6PF18; Q9H2S5: RNF39; NbExp=3; IntAct=EBI-9675802, EBI-12235180;
CC Q6PF18; Q8WYR4: RSPH1; NbExp=7; IntAct=EBI-9675802, EBI-10253582;
CC Q6PF18; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-9675802, EBI-6257312;
CC Q6PF18; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-9675802, EBI-748391;
CC Q6PF18; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-9675802, EBI-747035;
CC Q6PF18; P35711: SOX5; NbExp=3; IntAct=EBI-9675802, EBI-3505701;
CC Q6PF18; P51687: SUOX; NbExp=3; IntAct=EBI-9675802, EBI-3921347;
CC Q6PF18; Q5VWN6-2: TASOR2; NbExp=3; IntAct=EBI-9675802, EBI-10172380;
CC Q6PF18; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-9675802, EBI-750487;
CC Q6PF18; Q13077: TRAF1; NbExp=8; IntAct=EBI-9675802, EBI-359224;
CC Q6PF18; Q12933: TRAF2; NbExp=6; IntAct=EBI-9675802, EBI-355744;
CC Q6PF18; Q15645: TRIP13; NbExp=3; IntAct=EBI-9675802, EBI-358993;
CC Q6PF18; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-9675802, EBI-11962468;
CC Q6PF18; P36508: ZNF76; NbExp=3; IntAct=EBI-9675802, EBI-7254550;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PF18-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PF18-2; Sequence=VSP_019996, VSP_019997;
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DR EMBL; AY177732; AAO18675.1; -; mRNA.
DR EMBL; AC084018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC140062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057760; AAH57760.1; -; mRNA.
DR CCDS; CCDS31917.1; -. [Q6PF18-1]
DR RefSeq; NP_776254.3; NM_173855.4. [Q6PF18-1]
DR RefSeq; XP_005253926.1; XM_005253869.4.
DR RefSeq; XP_011536515.1; XM_011538213.2. [Q6PF18-1]
DR AlphaFoldDB; Q6PF18; -.
DR SMR; Q6PF18; -.
DR BioGRID; 129545; 68.
DR IntAct; Q6PF18; 70.
DR MINT; Q6PF18; -.
DR STRING; 9606.ENSP00000347486; -.
DR iPTMnet; Q6PF18; -.
DR PhosphoSitePlus; Q6PF18; -.
DR BioMuta; MORN3; -.
DR DMDM; 296438295; -.
DR MassIVE; Q6PF18; -.
DR PaxDb; Q6PF18; -.
DR PeptideAtlas; Q6PF18; -.
DR PRIDE; Q6PF18; -.
DR ProteomicsDB; 67103; -. [Q6PF18-1]
DR ProteomicsDB; 67104; -. [Q6PF18-2]
DR Antibodypedia; 64782; 94 antibodies from 16 providers.
DR DNASU; 283385; -.
DR Ensembl; ENST00000355329.7; ENSP00000347486.3; ENSG00000139714.12. [Q6PF18-1]
DR Ensembl; ENST00000392462.6; ENSP00000376255.2; ENSG00000139714.12. [Q6PF18-2]
DR Ensembl; ENST00000542364.1; ENSP00000445643.1; ENSG00000139714.12. [Q6PF18-2]
DR GeneID; 283385; -.
DR KEGG; hsa:283385; -.
DR MANE-Select; ENST00000355329.7; ENSP00000347486.3; NM_173855.5; NP_776254.3.
DR UCSC; uc001uax.4; human. [Q6PF18-1]
DR CTD; 283385; -.
DR DisGeNET; 283385; -.
DR GeneCards; MORN3; -.
DR HGNC; HGNC:29807; MORN3.
DR HPA; ENSG00000139714; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q6PF18; -.
DR OpenTargets; ENSG00000139714; -.
DR PharmGKB; PA143485546; -.
DR VEuPathDB; HostDB:ENSG00000139714; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000159285; -.
DR HOGENOM; CLU_032017_3_0_1; -.
DR InParanoid; Q6PF18; -.
DR OMA; GEGKQYY; -.
DR OrthoDB; 1309439at2759; -.
DR PhylomeDB; Q6PF18; -.
DR TreeFam; TF323893; -.
DR PathwayCommons; Q6PF18; -.
DR SignaLink; Q6PF18; -.
DR BioGRID-ORCS; 283385; 11 hits in 1068 CRISPR screens.
DR ChiTaRS; MORN3; human.
DR GenomeRNAi; 283385; -.
DR Pharos; Q6PF18; Tdark.
DR PRO; PR:Q6PF18; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6PF18; protein.
DR Bgee; ENSG00000139714; Expressed in sperm and 134 other tissues.
DR ExpressionAtlas; Q6PF18; baseline and differential.
DR Genevisible; Q6PF18; HS.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 5.
DR SMART; SM00698; MORN; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..240
FT /note="MORN repeat-containing protein 3"
FT /id="PRO_0000247459"
FT REPEAT 38..60
FT /note="MORN 1"
FT REPEAT 62..84
FT /note="MORN 2"
FT REPEAT 91..113
FT /note="MORN 3"
FT REPEAT 114..136
FT /note="MORN 4"
FT REPEAT 137..159
FT /note="MORN 5"
FT REPEAT 160..182
FT /note="MORN 6"
FT REPEAT 184..205
FT /note="MORN 7"
FT VAR_SEQ 155..160
FT /note="KNGNRY -> SQNPRP (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_019996"
FT VAR_SEQ 161..240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_019997"
FT CONFLICT 43
FT /note="K -> E (in Ref. 3; AAH57760)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 27585 MW; 8B87C00C47203D55 CRC64;
MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK GTQVWKKKGA
IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK SGYGIQFFGP KEYYEGDWCG
SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG MLRLKNGNRY EGCWERGMKN GAGRFFHLDH
GQLFEGFWVD NMAKCGTMID FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD
