MORN4_BOVIN
ID MORN4_BOVIN Reviewed; 146 AA.
AC Q0VD26; Q5E9T3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=MORN repeat-containing protein 4;
DE AltName: Full=Retinophilin {ECO:0000303|PubMed:17285308};
GN Name=MORN4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=17285308; DOI=10.1007/s00438-007-0211-7;
RA Mecklenburg K.L.;
RT "Drosophila retinophilin contains MORN repeats and is conserved in
RT humans.";
RL Mol. Genet. Genomics 277:481-489(2007).
CC -!- FUNCTION: Plays a role in promoting axonal degeneration following
CC neuronal injury by toxic insult or trauma.
CC {ECO:0000250|UniProtKB:Q6PGF2}.
CC -!- SUBUNIT: Interacts with MYO3A. {ECO:0000250|UniProtKB:Q8NDC4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, filopodium tip {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in
CC the cytoplasm in the absence of MYO3A and localizes at filopodial tips
CC in the presence of MYO3A. {ECO:0000250|UniProtKB:Q8NDC4}.
CC -!- TISSUE SPECIFICITY: Retina. {ECO:0000269|PubMed:17285308}.
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DR EMBL; BT020837; AAX08854.1; -; mRNA.
DR EMBL; BC119872; AAI19873.1; -; mRNA.
DR RefSeq; NP_001030527.1; NM_001035450.1.
DR RefSeq; XP_005225677.1; XM_005225620.3.
DR AlphaFoldDB; Q0VD26; -.
DR SMR; Q0VD26; -.
DR STRING; 9913.ENSBTAP00000014795; -.
DR PaxDb; Q0VD26; -.
DR Ensembl; ENSBTAT00000014795; ENSBTAP00000014795; ENSBTAG00000011137.
DR GeneID; 614519; -.
DR KEGG; bta:614519; -.
DR CTD; 118812; -.
DR VEuPathDB; HostDB:ENSBTAG00000011137; -.
DR VGNC; VGNC:31561; MORN4.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00730000111173; -.
DR HOGENOM; CLU_113346_0_0_1; -.
DR InParanoid; Q0VD26; -.
DR OMA; WFPDGAK; -.
DR OrthoDB; 1532474at2759; -.
DR TreeFam; TF323893; -.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000011137; Expressed in floor plate of diencephalon and 105 other tissues.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
DR GO; GO:0048678; P:response to axon injury; ISS:UniProtKB.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 4.
DR SMART; SM00698; MORN; 4.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..146
FT /note="MORN repeat-containing protein 4"
FT /id="PRO_0000279487"
FT REPEAT 16..38
FT /note="MORN 1"
FT REPEAT 39..61
FT /note="MORN 2"
FT REPEAT 62..84
FT /note="MORN 3"
FT REPEAT 85..107
FT /note="MORN 4"
FT CONFLICT 88
FT /note="E -> D (in Ref. 1; AAX08854)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 16135 MW; 5BAE1C7B6E6AA7AC CRC64;
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG FGVLTFSDGS
RYEGEFAQGK FNGVGVFIRH DNMTFEGEFK NGRVDGLGLL TFPDGSHGIP RNEGLFENNK
LLRREKCSAV VQRAQSASKS ARSLTA
