MORN4_HUMAN
ID MORN4_HUMAN Reviewed; 146 AA.
AC Q8NDC4; Q86Y54;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=MORN repeat-containing protein 4;
DE AltName: Full=Protein 44050;
DE AltName: Full=Retinophilin {ECO:0000303|PubMed:17285308};
GN Name=MORN4; Synonyms=C10orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Moschonas N.K.;
RT "Homo sapiens gene 44050.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17285308; DOI=10.1007/s00438-007-0211-7;
RA Mecklenburg K.L.;
RT "Drosophila retinophilin contains MORN repeats and is conserved in
RT humans.";
RL Mol. Genet. Genomics 277:481-489(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH MYO3A, AND SUBCELLULAR LOCATION.
RX PubMed=25822849; DOI=10.1371/journal.pone.0122502;
RA Mecklenburg K.L., Freed S.A., Raval M., Quintero O.A., Yengo C.M.,
RA O'Tousa J.E.;
RT "Invertebrate and vertebrate class III myosins interact with MORN repeat-
RT containing adaptor proteins.";
RL PLoS ONE 10:E0122502-E0122502(2015).
CC -!- FUNCTION: Plays a role in promoting axonal degeneration following
CC neuronal injury by toxic insult or trauma.
CC {ECO:0000250|UniProtKB:Q6PGF2}.
CC -!- SUBUNIT: Interacts with MYO3A. {ECO:0000269|PubMed:25822849}.
CC -!- INTERACTION:
CC Q8NDC4; Q6Q788: APOA5; NbExp=3; IntAct=EBI-10269566, EBI-3936819;
CC Q8NDC4; Q5T5X7: BEND3; NbExp=6; IntAct=EBI-10269566, EBI-1211496;
CC Q8NDC4; Q9NQ79: CRTAC1; NbExp=3; IntAct=EBI-10269566, EBI-10205543;
CC Q8NDC4; Q8WXX5: DNAJC9; NbExp=3; IntAct=EBI-10269566, EBI-2349100;
CC Q8NDC4; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-10269566, EBI-371922;
CC Q8NDC4; B7ZLH0: FAM22F; NbExp=6; IntAct=EBI-10269566, EBI-10220102;
CC Q8NDC4; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10269566, EBI-11978177;
CC Q8NDC4; O75330: HMMR; NbExp=4; IntAct=EBI-10269566, EBI-2556203;
CC Q8NDC4; O75330-3: HMMR; NbExp=3; IntAct=EBI-10269566, EBI-12098658;
CC Q8NDC4; Q8NBZ0: INO80E; NbExp=3; IntAct=EBI-10269566, EBI-769401;
CC Q8NDC4; Q7Z3Z0: KRT25; NbExp=3; IntAct=EBI-10269566, EBI-11980019;
CC Q8NDC4; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10269566, EBI-3044087;
CC Q8NDC4; Q86UL8-2: MAGI2; NbExp=3; IntAct=EBI-10269566, EBI-12081182;
CC Q8NDC4; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-10269566, EBI-10178410;
CC Q8NDC4; Q9P242: NYAP2; NbExp=3; IntAct=EBI-10269566, EBI-10269689;
CC Q8NDC4; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-10269566, EBI-2876622;
CC Q8NDC4; P17081: RHOQ; NbExp=3; IntAct=EBI-10269566, EBI-689202;
CC Q8NDC4; Q9NVA2: SEPTIN11; NbExp=3; IntAct=EBI-10269566, EBI-957999;
CC Q8NDC4; Q14141: SEPTIN6; NbExp=6; IntAct=EBI-10269566, EBI-745901;
CC Q8NDC4; Q16143: SNCB; NbExp=6; IntAct=EBI-10269566, EBI-727106;
CC Q8NDC4; Q9Y2D8: SSX2IP; NbExp=6; IntAct=EBI-10269566, EBI-2212028;
CC Q8NDC4; Q9HCH5-13: SYTL2; NbExp=3; IntAct=EBI-10269566, EBI-14291493;
CC Q8NDC4; Q99081: TCF12; NbExp=3; IntAct=EBI-10269566, EBI-722877;
CC Q8NDC4; Q99081-3: TCF12; NbExp=3; IntAct=EBI-10269566, EBI-11952764;
CC Q8NDC4; P15884: TCF4; NbExp=3; IntAct=EBI-10269566, EBI-533224;
CC Q8NDC4; P15884-3: TCF4; NbExp=3; IntAct=EBI-10269566, EBI-13636688;
CC Q8NDC4; P36406: TRIM23; NbExp=6; IntAct=EBI-10269566, EBI-740098;
CC Q8NDC4; Q96DX7: TRIM44; NbExp=3; IntAct=EBI-10269566, EBI-8787399;
CC Q8NDC4; Q9Y2W2: WBP11; NbExp=3; IntAct=EBI-10269566, EBI-714455;
CC Q8NDC4; P52739-2: ZNF131; NbExp=3; IntAct=EBI-10269566, EBI-10213055;
CC Q8NDC4; A0A384ME25; NbExp=8; IntAct=EBI-10269566, EBI-10211777;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25822849}. Cell
CC projection, filopodium tip {ECO:0000269|PubMed:25822849}. Cell
CC projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in
CC the cytoplasm in the absence of MYO3A and localizes at filopodial tips
CC in the presence of MYO3A. {ECO:0000269|PubMed:25822849}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NDC4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDC4-2; Sequence=VSP_023457;
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DR EMBL; AJ431726; CAD24475.1; -; mRNA.
DR EMBL; AJ312050; CAC85055.1; -; mRNA.
DR EMBL; AL834132; CAD38849.1; -; mRNA.
DR EMBL; AL355315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093023; AAH93023.1; -; mRNA.
DR EMBL; BC010230; AAH10230.1; -; mRNA.
DR EMBL; BC040015; AAH40015.1; -; mRNA.
DR CCDS; CCDS7468.1; -. [Q8NDC4-1]
DR RefSeq; NP_001092301.1; NM_001098831.1. [Q8NDC4-1]
DR RefSeq; NP_849154.1; NM_178832.3. [Q8NDC4-1]
DR RefSeq; XP_011537552.1; XM_011539250.2. [Q8NDC4-2]
DR RefSeq; XP_011537553.1; XM_011539251.2. [Q8NDC4-1]
DR AlphaFoldDB; Q8NDC4; -.
DR SMR; Q8NDC4; -.
DR BioGRID; 125622; 34.
DR IntAct; Q8NDC4; 29.
DR MINT; Q8NDC4; -.
DR STRING; 9606.ENSP00000307636; -.
DR BioMuta; MORN4; -.
DR DMDM; 74751218; -.
DR MassIVE; Q8NDC4; -.
DR PaxDb; Q8NDC4; -.
DR PeptideAtlas; Q8NDC4; -.
DR PRIDE; Q8NDC4; -.
DR ProteomicsDB; 73013; -. [Q8NDC4-1]
DR ProteomicsDB; 73014; -. [Q8NDC4-2]
DR Antibodypedia; 30988; 45 antibodies from 16 providers.
DR DNASU; 118812; -.
DR Ensembl; ENST00000307450.11; ENSP00000307636.6; ENSG00000171160.18. [Q8NDC4-1]
DR GeneID; 118812; -.
DR KEGG; hsa:118812; -.
DR MANE-Select; ENST00000307450.11; ENSP00000307636.6; NM_178832.4; NP_849154.1.
DR UCSC; uc001kob.5; human. [Q8NDC4-1]
DR CTD; 118812; -.
DR DisGeNET; 118812; -.
DR GeneCards; MORN4; -.
DR HGNC; HGNC:24001; MORN4.
DR HPA; ENSG00000171160; Low tissue specificity.
DR MIM; 617736; gene.
DR neXtProt; NX_Q8NDC4; -.
DR OpenTargets; ENSG00000171160; -.
DR PharmGKB; PA162396074; -.
DR VEuPathDB; HostDB:ENSG00000171160; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00730000111173; -.
DR HOGENOM; CLU_113346_0_0_1; -.
DR InParanoid; Q8NDC4; -.
DR OMA; WFPDGAK; -.
DR OrthoDB; 1532474at2759; -.
DR PhylomeDB; Q8NDC4; -.
DR TreeFam; TF323893; -.
DR PathwayCommons; Q8NDC4; -.
DR SignaLink; Q8NDC4; -.
DR BioGRID-ORCS; 118812; 12 hits in 1077 CRISPR screens.
DR ChiTaRS; MORN4; human.
DR GenomeRNAi; 118812; -.
DR Pharos; Q8NDC4; Tdark.
DR PRO; PR:Q8NDC4; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8NDC4; protein.
DR Bgee; ENSG00000171160; Expressed in cortical plate and 161 other tissues.
DR ExpressionAtlas; Q8NDC4; baseline and differential.
DR Genevisible; Q8NDC4; HS.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0032433; C:filopodium tip; IDA:UniProtKB.
DR GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
DR GO; GO:0048678; P:response to axon injury; ISS:UniProtKB.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 4.
DR SMART; SM00698; MORN; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Reference proteome;
KW Repeat.
FT CHAIN 1..146
FT /note="MORN repeat-containing protein 4"
FT /id="PRO_0000279488"
FT REPEAT 16..38
FT /note="MORN 1"
FT REPEAT 39..61
FT /note="MORN 2"
FT REPEAT 62..84
FT /note="MORN 3"
FT REPEAT 85..107
FT /note="MORN 4"
FT VAR_SEQ 1..22
FT /note="MTLTKGSFTYSSGEEYRGEWKE -> MAWSRAGPMRSGVAPGCLGNSQWAAG
FT IVPSAVAQDGGVKWGNRWWRWRRARWQPGAHQRKSPRRWNPASRRDGHPERPAP (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_023457"
SQ SEQUENCE 146 AA; 16236 MW; 4DCF6DAD95100D1C CRC64;
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG FGVLTFSDGS
RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL TFPDGSHGIP RNEGLFENNK
LLRREKCSAI VQRAQSASKS ARNLTA
