MORN4_MOUSE
ID MORN4_MOUSE Reviewed; 146 AA.
AC Q6PGF2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=MORN repeat-containing protein 4;
GN Name=Morn4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22496551; DOI=10.1523/jneurosci.4951-11.2012;
RA Bhattacharya M.R., Gerdts J., Naylor S.A., Royse E.X., Ebstein S.Y.,
RA Sasaki Y., Milbrandt J., DiAntonio A.;
RT "A model of toxic neuropathy in Drosophila reveals a role for MORN4 in
RT promoting axonal degeneration.";
RL J. Neurosci. 32:5054-5061(2012).
RN [3]
RP INTERACTION WITH MYO3A, AND SUBCELLULAR LOCATION.
RX PubMed=26754646; DOI=10.1083/jcb.201509017;
RA Lelli A., Michel V., Boutet de Monvel J., Cortese M., Bosch-Grau M.,
RA Aghaie A., Perfettini I., Dupont T., Avan P., El-Amraoui A., Petit C.;
RT "Class III myosins shape the auditory hair bundles by limiting microvilli
RT and stereocilia growth.";
RL J. Cell Biol. 212:231-244(2016).
CC -!- FUNCTION: Plays a role in promoting axonal degeneration following
CC neuronal injury by toxic insult or trauma.
CC {ECO:0000269|PubMed:22496551}.
CC -!- SUBUNIT: Interacts with MYO3A. {ECO:0000269|PubMed:26754646}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, filopodium tip {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, stereocilium {ECO:0000269|PubMed:26754646}. Note=Found in
CC the cytoplasm in the absence of MYO3A and localizes at filopodial tips
CC in the presence of MYO3A. {ECO:0000250|UniProtKB:Q8NDC4}.
CC -!- DISRUPTION PHENOTYPE: Severed Morn4 null axons show significantly
CC reduced and delayed axonal degeneration following axotomy and
CC protection is evident for at least 72 hrs, whereas wild-type axons
CC degenerate within the first 12 hrs. {ECO:0000269|PubMed:22496551}.
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DR EMBL; AK154147; BAE32407.1; -; mRNA.
DR EMBL; AK159230; BAE34916.1; -; mRNA.
DR CCDS; CCDS37990.1; -.
DR RefSeq; NP_932776.1; NM_198108.2.
DR PDB; 6JLE; X-ray; 1.55 A; A=1-146.
DR PDBsum; 6JLE; -.
DR AlphaFoldDB; Q6PGF2; -.
DR SMR; Q6PGF2; -.
DR BioGRID; 230476; 1.
DR STRING; 10090.ENSMUSP00000062887; -.
DR MaxQB; Q6PGF2; -.
DR PaxDb; Q6PGF2; -.
DR PeptideAtlas; Q6PGF2; -.
DR PRIDE; Q6PGF2; -.
DR ProteomicsDB; 252594; -.
DR Antibodypedia; 30988; 45 antibodies from 16 providers.
DR DNASU; 226123; -.
DR Ensembl; ENSMUST00000051772; ENSMUSP00000062887; ENSMUSG00000049670.
DR GeneID; 226123; -.
DR KEGG; mmu:226123; -.
DR UCSC; uc008hnd.1; mouse.
DR CTD; 118812; -.
DR MGI; MGI:2449568; Morn4.
DR VEuPathDB; HostDB:ENSMUSG00000049670; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00730000111173; -.
DR HOGENOM; CLU_113346_0_0_1; -.
DR InParanoid; Q6PGF2; -.
DR OMA; WFPDGAK; -.
DR OrthoDB; 1532474at2759; -.
DR PhylomeDB; Q6PGF2; -.
DR TreeFam; TF323893; -.
DR BioGRID-ORCS; 226123; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Morn4; mouse.
DR PRO; PR:Q6PGF2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6PGF2; protein.
DR Bgee; ENSMUSG00000049670; Expressed in cortical plate and 215 other tissues.
DR Genevisible; Q6PGF2; MM.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR GO; GO:0032426; C:stereocilium tip; IDA:UniProtKB.
DR GO; GO:0048678; P:response to axon injury; IMP:UniProtKB.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 4.
DR SMART; SM00698; MORN; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..146
FT /note="MORN repeat-containing protein 4"
FT /id="PRO_0000279489"
FT REPEAT 16..38
FT /note="MORN 1"
FT REPEAT 39..61
FT /note="MORN 2"
FT REPEAT 62..84
FT /note="MORN 3"
FT REPEAT 85..107
FT /note="MORN 4"
FT STRAND 4..9
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 15..21
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 24..32
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 38..44
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 47..55
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 61..67
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 70..78
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 84..90
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 93..101
FT /evidence="ECO:0007829|PDB:6JLE"
FT TURN 108..111
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 113..117
FT /evidence="ECO:0007829|PDB:6JLE"
FT STRAND 120..124
FT /evidence="ECO:0007829|PDB:6JLE"
FT HELIX 128..142
FT /evidence="ECO:0007829|PDB:6JLE"
SQ SEQUENCE 146 AA; 16206 MW; FF4248B264F00D0A CRC64;
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LVFADGGTYL GHFENGLFNG FGVLTFSDGS
RYEGEFSQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL TFPDGSHGIP RNEGLFENNK
LLRREKCSAV VQRAQSASKS ARNLTA
