MORN4_PONAB
ID MORN4_PONAB Reviewed; 146 AA.
AC Q5R578;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=MORN repeat-containing protein 4;
GN Name=MORN4;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in promoting axonal degeneration following
CC neuronal injury by toxic insult or trauma.
CC {ECO:0000250|UniProtKB:Q6PGF2}.
CC -!- SUBUNIT: Interacts with MYO3A. {ECO:0000250|UniProtKB:Q8NDC4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, filopodium tip {ECO:0000250|UniProtKB:Q8NDC4}. Cell
CC projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in
CC the cytoplasm in the absence of MYO3A and localizes at filopodial tips
CC in the presence of MYO3A. {ECO:0000250|UniProtKB:Q8NDC4}.
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DR EMBL; CR860986; CAH93088.1; -; mRNA.
DR RefSeq; NP_001126828.1; NM_001133356.1.
DR AlphaFoldDB; Q5R578; -.
DR SMR; Q5R578; -.
DR STRING; 9601.ENSPPYP00000002945; -.
DR Ensembl; ENSPPYT00000043703; ENSPPYP00000028389; ENSPPYG00000031901.
DR GeneID; 100173834; -.
DR KEGG; pon:100173834; -.
DR CTD; 118812; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00730000111173; -.
DR HOGENOM; CLU_113346_0_0_1; -.
DR InParanoid; Q5R578; -.
DR OMA; WFPDGAK; -.
DR OrthoDB; 1532474at2759; -.
DR TreeFam; TF323893; -.
DR Proteomes; UP000001595; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
DR GO; GO:0048678; P:response to axon injury; ISS:UniProtKB.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 4.
DR SMART; SM00698; MORN; 4.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..146
FT /note="MORN repeat-containing protein 4"
FT /id="PRO_0000279490"
FT REPEAT 16..38
FT /note="MORN 1"
FT REPEAT 39..61
FT /note="MORN 2"
FT REPEAT 62..84
FT /note="MORN 3"
FT REPEAT 85..107
FT /note="MORN 4"
SQ SEQUENCE 146 AA; 16236 MW; 4DCF6DAD95100D1C CRC64;
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG FGVLTFSDGS
RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL TFPDGSHGIP RNEGLFENNK
LLRREKCSAI VQRAQSASKS ARNLTA