MORN5_HUMAN
ID MORN5_HUMAN Reviewed; 161 AA.
AC Q5VZ52; B7Z7I5; Q6ZQN1;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=MORN repeat-containing protein 5;
GN Name=MORN5; Synonyms=C9orf113, C9orf18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Teratocarcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5VZ52; P21549: AGXT; NbExp=3; IntAct=EBI-12835568, EBI-727098;
CC Q5VZ52; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-12835568, EBI-744099;
CC Q5VZ52; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-12835568, EBI-7960826;
CC Q5VZ52; O14929: HAT1; NbExp=5; IntAct=EBI-12835568, EBI-2339359;
CC Q5VZ52; Q8IVT2: MISP; NbExp=3; IntAct=EBI-12835568, EBI-2555085;
CC Q5VZ52; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-12835568, EBI-11956563;
CC Q5VZ52; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-12835568, EBI-745021;
CC Q5VZ52; O43711: TLX3; NbExp=3; IntAct=EBI-12835568, EBI-3939165;
CC Q5VZ52; O75604: USP2; NbExp=3; IntAct=EBI-12835568, EBI-743272;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VZ52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VZ52-2; Sequence=VSP_055496;
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DR EMBL; AK128877; BAC87653.1; -; mRNA.
DR EMBL; AK302081; BAH13621.1; -; mRNA.
DR EMBL; AL162423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL162424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87512.1; -; Genomic_DNA.
DR EMBL; BC133690; AAI33691.1; -; mRNA.
DR CCDS; CCDS6836.1; -. [Q5VZ52-1]
DR RefSeq; NP_001273757.1; NM_001286828.1.
DR RefSeq; NP_940871.2; NM_198469.3. [Q5VZ52-1]
DR RefSeq; XP_005251934.1; XM_005251877.4.
DR AlphaFoldDB; Q5VZ52; -.
DR SMR; Q5VZ52; -.
DR BioGRID; 129063; 19.
DR IntAct; Q5VZ52; 12.
DR STRING; 9606.ENSP00000362869; -.
DR iPTMnet; Q5VZ52; -.
DR PhosphoSitePlus; Q5VZ52; -.
DR BioMuta; MORN5; -.
DR DMDM; 74747757; -.
DR MassIVE; Q5VZ52; -.
DR PaxDb; Q5VZ52; -.
DR PeptideAtlas; Q5VZ52; -.
DR PRIDE; Q5VZ52; -.
DR ProteomicsDB; 65672; -. [Q5VZ52-1]
DR ProteomicsDB; 6873; -.
DR Antibodypedia; 16056; 78 antibodies from 14 providers.
DR DNASU; 254956; -.
DR Ensembl; ENST00000373764.8; ENSP00000362869.3; ENSG00000185681.13. [Q5VZ52-1]
DR GeneID; 254956; -.
DR KEGG; hsa:254956; -.
DR MANE-Select; ENST00000373764.8; ENSP00000362869.3; NM_198469.4; NP_940871.2.
DR UCSC; uc004blw.4; human. [Q5VZ52-1]
DR CTD; 254956; -.
DR DisGeNET; 254956; -.
DR GeneCards; MORN5; -.
DR HGNC; HGNC:17841; MORN5.
DR HPA; ENSG00000185681; Group enriched (fallopian tube, testis).
DR MIM; 619837; gene.
DR neXtProt; NX_Q5VZ52; -.
DR OpenTargets; ENSG00000185681; -.
DR PharmGKB; PA25975; -.
DR VEuPathDB; HostDB:ENSG00000185681; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00390000018089; -.
DR HOGENOM; CLU_117237_0_0_1; -.
DR InParanoid; Q5VZ52; -.
DR OMA; FPTDTKY; -.
DR OrthoDB; 1312559at2759; -.
DR PhylomeDB; Q5VZ52; -.
DR TreeFam; TF327409; -.
DR PathwayCommons; Q5VZ52; -.
DR SignaLink; Q5VZ52; -.
DR BioGRID-ORCS; 254956; 11 hits in 1062 CRISPR screens.
DR GenomeRNAi; 254956; -.
DR Pharos; Q5VZ52; Tdark.
DR PRO; PR:Q5VZ52; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5VZ52; protein.
DR Bgee; ENSG00000185681; Expressed in bronchial epithelial cell and 122 other tissues.
DR ExpressionAtlas; Q5VZ52; baseline and differential.
DR Genevisible; Q5VZ52; HS.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR042814; Morn5.
DR PANTHER; PTHR46437; PTHR46437; 1.
DR Pfam; PF02493; MORN; 3.
DR SMART; SM00698; MORN; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..161
FT /note="MORN repeat-containing protein 5"
FT /id="PRO_0000292840"
FT REPEAT 8..30
FT /note="MORN 1"
FT REPEAT 31..53
FT /note="MORN 2"
FT REPEAT 54..75
FT /note="MORN 3"
FT VAR_SEQ 147..161
FT /note="DDDEHEWITRTCRKG -> GRFLPTLQHVFSSPTYEYVHLYVQMYAHT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055496"
FT CONFLICT 45
FT /note="T -> A (in Ref. 1; BAC87653)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 161 AA; 18731 MW; C0DA34ED1D015866 CRC64;
MEYTGSKYIG EYVDGRMEGK AKYILPTETI YVGEMKDGMF HGEGTLYFPS GSQYDAIWEN
GLAIKGTYTF SDGLHYDEKN WHYCDGYDRR FYTEILNGLK PAGMAQLTNM DPPRKIPKGY
YDCGDGFYNP VTRVVKDYRN RFLRNADDDE HEWITRTCRK G
