ID   MORN_HUMAN              Reviewed;          11 AA.
AC   P69208; P01163;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Morphogenetic neuropeptide;
DE   AltName: Full=Head activator;
DE            Short=HA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX   PubMed=7290191; DOI=10.1038/293579a0;
RA   Bodenmuller H., Schaller H.C.;
RT   "Conserved amino acid sequence of a neuropeptide, the head activator, from
RT   coelenterates to humans.";
RL   Nature 293:579-580(1981).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=7297679; DOI=10.1016/0014-5793(81)80394-8;
RA   Birr C., Zachmann B., Bodenmuller H., Schaller H.C.;
RT   "Synthesis of a new neuropeptide, the head activator from hydra.";
RL   FEBS Lett. 131:317-321(1981).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH SORL1.
RX   PubMed=11082041; DOI=10.1242/jcs.113.24.4475;
RA   Hampe W., Riedel I.B., Lintzel J., Bader C.O., Franke I., Schaller H.C.;
RT   "Ectodomain shedding, translocation and synthesis of SorLA are stimulated
RT   by its ligand head activator.";
RL   J. Cell Sci. 113:4475-4485(2000).
RN   [4]
RP   INTERACTION WITH SORL1.
RX   PubMed=11294867; DOI=10.1074/jbc.m100857200;
RA   Jacobsen L., Madsen P., Jacobsen C., Nielsen M.S., Gliemann J.,
RA   Petersen C.M.;
RT   "Activation and functional characterization of the mosaic receptor
RT   SorLA/LR11.";
RL   J. Biol. Chem. 276:22788-22796(2001).
RN   [5]
RP   INTERACTION WITH SORL1.
RX   PubMed=12530537; DOI=10.1515/bc.2002.193;
RA   Lintzel J., Franke I., Riedel I.B., Schaller H.C., Hampe W.;
RT   "Characterization of the VPS10 domain of SorLA/LR11 as binding site for the
RT   neuropeptide HA.";
RL   Biol. Chem. 383:1727-1733(2002).
CC   -!- FUNCTION: Stimulates the proliferation of neural cells.
CC       {ECO:0000269|PubMed:11082041}.
CC   -!- SUBUNIT: May interact with SORL1 (via N-terminal ectodomain); this
CC       interaction is impaired in the presence of SORL1 propeptide.
CC       {ECO:0000269|PubMed:11082041, ECO:0000269|PubMed:11294867,
CC       ECO:0000269|PubMed:12530537}.
CC   -!- CAUTION: This peptide was first isolated from nerve cells of hydra and
CC       was called head activator by the authors, because it induced head-
CC       specific growth and differentiation in this animal. It has been found
CC       in mammalian intestine and hypothalamus. The peptide sequence could not
CC       be mapped onto the reference genome. {ECO:0000305}.
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DR   PIR; B01427; YHHU.
DR   PeptideAtlas; P69208; -.
DR   Pharos; P69208; Tdark.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0048018; F:receptor ligand activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0002031; P:G protein-coupled receptor internalization; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0090068; P:positive regulation of cell cycle process; IDA:UniProtKB.
DR   GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:UniProtKB.
DR   GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IDA:UniProtKB.
DR   GO; GO:0034394; P:protein localization to cell surface; IDA:UniProtKB.
DR   GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Direct protein sequencing; Growth factor;
KW   Mitosis; Pyrrolidone carboxylic acid.
FT   PEPTIDE         1..11
FT                   /note="Morphogenetic neuropeptide"
FT                   /id="PRO_0000044167"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:7290191"
SQ   SEQUENCE   11 AA;  1142 MW;  37927417C325B878 CRC64;
     QPPGGSKVIL F