MOS14_ARATH
ID MOS14_ARATH Reviewed; 958 AA.
AC Q8GUL2; Q9FJI6;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transportin MOS14 {ECO:0000305};
DE AltName: Full=Importin beta MOS14 {ECO:0000305};
DE AltName: Full=Protein MODIFIER OF SNC1 14 {ECO:0000303|PubMed:21738492};
DE AltName: Full=Transportin-SR {ECO:0000303|PubMed:21738492};
DE Short=TRN-SR {ECO:0000303|PubMed:21738492};
GN Name=MOS14 {ECO:0000303|PubMed:21738492};
GN OrderedLocusNames=At5g62600 {ECO:0000312|Araport:AT5G62600};
GN ORFNames=K19B1.21 {ECO:0000312|EMBL:BAB11510.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, INTERACTION WITH RS2Z33; RSZ21; RS31A; SR34 AND RAN1, SUBCELLULAR
RP LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=21738492; DOI=10.1371/journal.pgen.1002159;
RA Xu S., Zhang Z., Jing B., Gannon P., Ding J., Xu F., Li X., Zhang Y.;
RT "Transportin-SR is required for proper splicing of resistance genes and
RT plant immunity.";
RL PLoS Genet. 7:E1002159-E1002159(2011).
CC -!- FUNCTION: Functions as nuclear import receptor for serine-arginine rich
CC (SR) proteins. Regulates nuclear import of SR proteins that are
CC required for proper splicing of the two resistance (R) genes SNC1 and
CC RPS4, a crucial step for their functions in plant immunity.
CC {ECO:0000269|PubMed:21738492}.
CC -!- SUBUNIT: Interacts with RS2Z33, RSZ21, RS31A, SR34 and RAN1.
CC {ECO:0000269|PubMed:21738492}.
CC -!- INTERACTION:
CC Q8GUL2; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-25520322, EBI-4426557;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21738492}.
CC -!- DISRUPTION PHENOTYPE: Semi-dwarf phenotype.
CC {ECO:0000269|PubMed:21738492}.
CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11510.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB015469; BAB11510.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB020751; BAB11510.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED97629.1; -; Genomic_DNA.
DR EMBL; BT002408; AAO00768.1; -; mRNA.
DR EMBL; BT010552; AAQ65175.1; -; mRNA.
DR EMBL; AK229829; BAF01659.1; -; mRNA.
DR EMBL; AK230415; BAF02213.1; -; mRNA.
DR RefSeq; NP_201066.2; NM_125655.4.
DR AlphaFoldDB; Q8GUL2; -.
DR SMR; Q8GUL2; -.
DR IntAct; Q8GUL2; 1.
DR STRING; 3702.AT5G62600.1; -.
DR PaxDb; Q8GUL2; -.
DR PRIDE; Q8GUL2; -.
DR ProteomicsDB; 238265; -.
DR EnsemblPlants; AT5G62600.1; AT5G62600.1; AT5G62600.
DR GeneID; 836381; -.
DR Gramene; AT5G62600.1; AT5G62600.1; AT5G62600.
DR KEGG; ath:AT5G62600; -.
DR Araport; AT5G62600; -.
DR TAIR; locus:2154159; AT5G62600.
DR eggNOG; KOG2081; Eukaryota.
DR HOGENOM; CLU_005996_2_0_1; -.
DR InParanoid; Q8GUL2; -.
DR OMA; KTINYCR; -.
DR OrthoDB; 206228at2759; -.
DR PhylomeDB; Q8GUL2; -.
DR PRO; PR:Q8GUL2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GUL2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IMP:TAIR.
DR GO; GO:0043484; P:regulation of RNA splicing; IMP:TAIR.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..958
FT /note="Transportin MOS14"
FT /id="PRO_0000436558"
FT DOMAIN 26..93
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ SEQUENCE 958 AA; 106917 MW; 6C1DC0E753DD7A0B CRC64;
MEHQNAVKEA LNALYHHPDD TVRVHADRWL QNFQGTLDAW QVADNLLHDS SSNLETLIFC
SQTLRSKVQR DFEELPPGAF QKLRQSLTTL LKKFHKGPPK VRTQISIAVA ALAVHVPAAD
WGDGGIISWL RDEMHMHPEY VPGFLELLTV LPEETFNYKI AARPDRRRQF EKELTSQMEA
ALSILSACLK ISELKEQVLE AFASWLRLRH GIPGTVLACH PLVHAALSSL NCDPLSEASV
NVISELIHHT ASPSSGGISA QTPLIQVIVP QILSLQAHLR DSSKDEEDVK AIGRLFADVG
DSYVELIATG SDEPMVIVHA LLEVTAHPEF DIASMTFNFW HSLQLMLTKR ESYSSLGSEA
SIEVERNRRL HIFQPAYQSL VSLVGFRVQY PEDYQGLSYE DLKEFKQTRY AVADVLIDAA
LILGGDTTLK ILYMKLLEAN AQTGNNFQDW RPAEAILFCI WAISNYVSVV EAEVMPQVMA
LLQNLPQQAQ LLQTACLLVG AYSKWLNAAP ASVSILPSII RILMSGMGTS EDCAAAAALA
FRHTCDDCRK NLCGYFEDLF NIYCMAINGG GGYKVSAEDS LNLVEALGMV VTELPLDQAK
GALEKLCFSA ASPLEEAAKE DLEKKHAREL TVHIDRFAFL FRYVNHPEAV AAEINKHWAI
FRVIFDARPW DMRTMESLCR ACKYAVRTSG RYIIDTIGEM LEKIQFHYQQ HHQPCFLYLS
SEVIKIFGSD PSCAVYLKNL IETLFAHTTC LMTSIKEVTA RPDIADDCFL LASRCLRYCP
HLFIPSPIFP ALVNCAMIGI TVQHREACHS ILTFLTDIFD LEKSVNEEQF VRIRDNIIIP
RGATITRILI ASLAGALPSS RLDTVTYSLL ALTRTYRLQA VSWAKESVSL IPRTALTETE
STKFLQALSD IAYGADVNSL IGQVEELSDV CRRNRTVQEL VQAALKPLEL NLVTAPVS
