ID   MOS2_ARATH              Reviewed;         462 AA.
AC   Q9C801;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Protein MOS2;
GN   Name=MOS2; OrderedLocusNames=At1g33520; ORFNames=F10C21.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=16271871; DOI=10.1016/j.cub.2005.09.038;
RA   Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.;
RT   "MOS2, a protein containing G-patch and KOW motifs, is essential for innate
RT   immunity in Arabidopsis thaliana.";
RL   Curr. Biol. 15:1936-1942(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Required for innate and induced resistance to pathogens such
CC       as compatible and incompatible isolates of P.syringae and P.parasitica.
CC       {ECO:0000269|PubMed:16271871}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16271871}.
CC   -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000305}.
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DR   EMBL; DQ202264; ABA64466.1; -; mRNA.
DR   EMBL; AC051630; AAG51225.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31602.1; -; Genomic_DNA.
DR   EMBL; AY091044; AAM13865.1; -; mRNA.
DR   EMBL; BT006036; AAP04023.1; -; mRNA.
DR   PIR; A86459; A86459.
DR   RefSeq; NP_174617.1; NM_103076.4.
DR   AlphaFoldDB; Q9C801; -.
DR   SMR; Q9C801; -.
DR   STRING; 3702.AT1G33520.1; -.
DR   iPTMnet; Q9C801; -.
DR   PaxDb; Q9C801; -.
DR   PRIDE; Q9C801; -.
DR   ProteomicsDB; 238309; -.
DR   EnsemblPlants; AT1G33520.1; AT1G33520.1; AT1G33520.
DR   GeneID; 840246; -.
DR   Gramene; AT1G33520.1; AT1G33520.1; AT1G33520.
DR   KEGG; ath:AT1G33520; -.
DR   Araport; AT1G33520; -.
DR   TAIR; locus:2007033; AT1G33520.
DR   eggNOG; KOG4315; Eukaryota.
DR   HOGENOM; CLU_031427_1_0_1; -.
DR   InParanoid; Q9C801; -.
DR   OMA; VEGNRVM; -.
DR   OrthoDB; 1427830at2759; -.
DR   PhylomeDB; Q9C801; -.
DR   PRO; PR:Q9C801; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C801; baseline and differential.
DR   Genevisible; Q9C801; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; ISS:TAIR.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   GO; GO:0002758; P:innate immune response-activating signal transduction; IMP:TAIR.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd13153; KOW_GPKOW_B; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR041994; GPKOW_KOW2.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR045166; Spp2-like.
DR   InterPro; IPR026822; Spp2/MOS2_G-patch.
DR   PANTHER; PTHR15818; PTHR15818; 1.
DR   Pfam; PF12656; G-patch_2; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00739; KOW; 2.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..462
FT                   /note="Protein MOS2"
FT                   /id="PRO_0000244843"
FT   DOMAIN          156..202
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   DOMAIN          231..258
FT                   /note="KOW 1"
FT   DOMAIN          401..428
FT                   /note="KOW 2"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51027 MW;  76D7A7A3E6FEE1B2 CRC64;
     MKLSFSLPSK SKPKVTATTA DGNNAVDDGT SKEFVTEFDP SKTLANSIPK YVIPPIENTW
     RPHKKMKNLD LPLQSGNAGS GLEFEPEVPL PGTEKPDNIS YGLNLRQKVK DDSIGGDAVE
     ERKVSMGEQL MLQSLRRDLM SLADDPTLED FESVPVDGFG AALMAGYGWK PGKGIGKNAK
     EDVEIKEYKK WTAKEGLGFD PDRSKVVDVK AKVKESVKLD KKGVGINGGD VFFVGKEVRI
     IAGRDVGLKG KIVEKPGSDF FVIKISGSEE EVKVGVNEVA DLGSKEEEKC LKKLKDLQLN
     DREKDKKTSG RGRGAERGSR SEVRASEKQD RGQTRERKVK PSWLRSHIKV RIVSKDWKGG
     RLYLKKGKVV DVVGPTTCDI TMDETQELVQ GVDQELLETA LPRRGGPVLV LSGKHKGVYG
     NLVEKDLDKE TGVVRDLDNH KMLDVRLDQV AEYMGDMDDI EY