ID   MOSC_RHIML              Reviewed;         407 AA.
AC   Q07609; Q52891;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Membrane protein MosC;
GN   Name=mosC;
OS   Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L5-30;
RX   PubMed=8349559; DOI=10.1128/jb.175.16.5193-5204.1993;
RA   Murphy P.J., Trenz S.P., Grzemski W., de Bruijn F.J., Schell J.;
RT   "The Rhizobium meliloti rhizopine mos locus is a mosaic structure
RT   facilitating its symbiotic regulation.";
RL   J. Bacteriol. 175:5193-5204(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RM220-3;
RX   PubMed=7551036; DOI=10.1099/13500872-141-7-1683;
RA   Rao J.P., Grzemski W., Murphy P.J.;
RT   "Rhizobium meliloti lacking mosA synthesizes the rhizopine scyllo-inosamine
RT   in place of 3-O-methyl-scyllo-inosamine.";
RL   Microbiology 141:1683-1690(1995).
CC   -!- FUNCTION: May be a membrane transport protein that could either
CC       transport a precursor for rhizopine biosynthesis into bacteroids or the
CC       finished product from the bacteroids.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=43 kDa;
CC         IsoId=Q07609-1; Sequence=Displayed;
CC       Name=41 kDa;
CC         IsoId=Q07609-2; Sequence=VSP_018820;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L17071; AAA26303.1; -; Genomic_DNA.
DR   EMBL; U23753; AAA91314.1; -; Genomic_DNA.
DR   PIR; D53308; D53308.
DR   AlphaFoldDB; Q07609; -.
DR   SMR; Q07609; -.
DR   TCDB; 2.A.1.60.1; the major facilitator superfamily (mfs).
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   4: Predicted;
KW   Alternative initiation; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..407
FT                   /note="Membrane protein MosC"
FT                   /id="PRO_0000021729"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..19
FT                   /note="Missing (in isoform 41 kDa)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018820"
FT   VARIANT         64
FT                   /note="N -> T (in strain: RM220-3)"
FT   VARIANT         71
FT                   /note="L -> G (in strain: RM220-3)"
FT   VARIANT         90
FT                   /note="S -> P (in strain: RM220-3)"
FT   VARIANT         100
FT                   /note="I -> N (in strain: RM220-3)"
FT   VARIANT         164
FT                   /note="S -> R (in strain: RM220-3)"
FT   VARIANT         174
FT                   /note="F -> L (in strain: RM220-3)"
FT   VARIANT         184
FT                   /note="A -> G (in strain: RM220-3)"
FT   VARIANT         212..214
FT                   /note="EHR -> KQK (in strain: RM220-3)"
FT   VARIANT         219
FT                   /note="E -> K (in strain: RM220-3)"
FT   VARIANT         254
FT                   /note="E -> G (in strain: RM220-3)"
FT   CONFLICT        369..384
FT                   /note="RIAEAVGLGRALLFII -> ASRRPLGSGELCSSSF (in Ref. 1;
FT                   AAA26303)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   407 AA;  43216 MW;  09C8F4C56AC7624F CRC64;
     MTRTSPRHHA PSETKRRVPM GGVHTNPGKK LTITAVAFQF FINGLVLAAW ATSIPHVKNA
     YSFNDAELGV LLLIMAAGAL LFMSLAGYFS HVFGSRRMSI QSALLFPSAL VLIFAAPNCM
     TFLCSIVLFG AANGAMDVLM NHQAKALEEN GFPRIMAFLH GCSSTGILAG IMTFGVIGDG
     HYVARSVTLL TGILIVARWL FPHLLDDVRS GEHRLAIGEL RNCKLLMFGI LSFLTMVTDG
     AIAEWSKLYL IRVEQVTDQV GSLGYVAFTL LMIAGRISGD RVKDAIGCRA LIAISGSLAS
     AGMTTALFMP SFAGKLAGFA LLGLGMANLV PIIFSEAASM NTVSKTVGLT FVSVCGYSGF
     LVGPPIIGRI AEAVGLGRAL LFIIAVGVIV ACASVFFDRH RSGQPEP