ID   MOSMO_DANRE             Reviewed;         167 AA.
AC   Q0D289;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Modulator of smoothened protein {ECO:0000250|UniProtKB:Q8NHV5};
DE   AltName: Full=Attenuator of hedgehog {ECO:0000250|UniProtKB:Q8C784};
GN   Name=mosmob {ECO:0000250|UniProtKB:Q8NHV5}; ORFNames=zgc:153595;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of hedgehog signaling probably
CC       by promoting internalization and subsequent degradation of smoothened
CC       protein (SMO) present in the ciliary membrane. Plays a role in sonic
CC       hedgehog (SHH)-induced spinal neural progenitor cells differentiation.
CC       {ECO:0000250|UniProtKB:Q8C784}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane; Multi-pass
CC       membrane protein {ECO:0000250|UniProtKB:Q8C784}. Cell membrane; Multi-
CC       pass membrane protein {ECO:0000250|UniProtKB:Q8C784}.
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DR   EMBL; BC122343; AAI22344.1; -; mRNA.
DR   RefSeq; NP_001070129.1; NM_001076661.1.
DR   AlphaFoldDB; Q0D289; -.
DR   STRING; 7955.ENSDARP00000052003; -.
DR   PaxDb; Q0D289; -.
DR   GeneID; 767723; -.
DR   KEGG; dre:767723; -.
DR   CTD; 767723; -.
DR   ZFIN; ZDB-GENE-060929-1030; mosmob.
DR   eggNOG; ENOG502R4TC; Eukaryota.
DR   InParanoid; Q0D289; -.
DR   OrthoDB; 1466125at2759; -.
DR   PhylomeDB; Q0D289; -.
DR   PRO; PR:Q0D289; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR   InterPro; IPR037663; Mosmo.
DR   PANTHER; PTHR31186; PTHR31186; 1.
DR   Pfam; PF18800; Atthog; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Differentiation; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..167
FT                   /note="Modulator of smoothened protein"
FT                   /id="PRO_0000271084"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   167 AA;  18192 MW;  566BCACA20CDBBB0 CRC64;
     MDKLTIISGC LFLAADIFAI ASIANPDWIN TGGQEGALTV GLVKQCQTIH GRNRICVSPS
     LPPEWVTTLF FIILGIVSLT ITCGLLVISH WRREATKYAR WIAFMGMVLF CMAALIFPVG
     FYINQVGGQP YKLPNNTVVG SSYVLFVLSI FFTIVGLLFA GKVCLPG