MOSMO_MOUSE
ID MOSMO_MOUSE Reviewed; 167 AA.
AC Q8C784; Q3TS22; Q8K0V1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Modulator of smoothened protein {ECO:0000312|MGI:MGI:2446240};
DE AltName: Full=Attenuator of hedgehog {ECO:0000303|PubMed:29290584};
GN Name=Mosmo {ECO:0000312|MGI:MGI:2446240};
GN Synonyms=Atthog {ECO:0000303|PubMed:29290584};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-167 (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 55-167 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=29290584; DOI=10.1016/j.devcel.2017.12.003;
RA Pusapati G.V., Kong J.H., Patel B.B., Krishnan A., Sagner A., Kinnebrew M.,
RA Briscoe J., Aravind L., Rohatgi R.;
RT "CRISPR screens uncover genes that regulate target cell sensitivity to the
RT morphogen sonic hedgehog.";
RL Dev. Cell 44:113-129(2018).
CC -!- FUNCTION: Acts as a negative regulator of hedgehog signaling probably
CC by promoting internalization and subsequent degradation of smoothened
CC protein (SMO) present in the ciliary membrane (PubMed:29290584). Plays
CC a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells
CC differentiation (PubMed:29290584). {ECO:0000269|PubMed:29290584}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000269|PubMed:29290584}; Multi-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29290584}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C784-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C784-2; Sequence=VSP_022277;
CC -!- DEVELOPMENTAL STAGE: Expressed in the ventral neural tube at 11.5 dpc.
CC {ECO:0000269|PubMed:29290584}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30336.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC030336; AAH30336.1; ALT_INIT; mRNA.
DR EMBL; BC053950; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK052350; BAC34951.1; -; mRNA.
DR EMBL; AK162324; BAE36854.1; -; mRNA.
DR CCDS; CCDS52381.1; -. [Q8C784-1]
DR RefSeq; NP_001158052.1; NM_001164580.1. [Q8C784-1]
DR RefSeq; XP_006507752.1; XM_006507689.2. [Q8C784-2]
DR AlphaFoldDB; Q8C784; -.
DR STRING; 10090.ENSMUSP00000055934; -.
DR GlyGen; Q8C784; 1 site.
DR PhosphoSitePlus; Q8C784; -.
DR PaxDb; Q8C784; -.
DR PRIDE; Q8C784; -.
DR Ensembl; ENSMUST00000060175; ENSMUSP00000055934; ENSMUSG00000046096. [Q8C784-1]
DR GeneID; 233812; -.
DR KEGG; mmu:233812; -.
DR UCSC; uc009jmx.2; mouse. [Q8C784-1]
DR CTD; 730094; -.
DR MGI; MGI:2446240; Mosmo.
DR VEuPathDB; HostDB:ENSMUSG00000046096; -.
DR eggNOG; ENOG502R4TC; Eukaryota.
DR GeneTree; ENSGT00390000018266; -.
DR HOGENOM; CLU_111296_0_0_1; -.
DR InParanoid; Q8C784; -.
DR OMA; VCFTPDL; -.
DR OrthoDB; 1466125at2759; -.
DR PhylomeDB; Q8C784; -.
DR TreeFam; TF324757; -.
DR BioGRID-ORCS; 233812; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Mosmo; mouse.
DR PRO; PR:Q8C784; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C784; protein.
DR Bgee; ENSMUSG00000046096; Expressed in otolith organ and 219 other tissues.
DR ExpressionAtlas; Q8C784; baseline and differential.
DR Genevisible; Q8C784; MM.
DR GO; GO:0060170; C:ciliary membrane; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:UniProtKB.
DR GO; GO:0045664; P:regulation of neuron differentiation; IMP:UniProtKB.
DR GO; GO:0031647; P:regulation of protein stability; IMP:UniProtKB.
DR InterPro; IPR037663; Mosmo.
DR PANTHER; PTHR31186; PTHR31186; 1.
DR Pfam; PF18800; Atthog; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cell projection; Differentiation;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..167
FT /note="Modulator of smoothened protein"
FT /id="PRO_0000271083"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 107..167
FT /note="MILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLL
FT FAGKVCLPG -> RWYSEMGYLLRSDLEWKTWVSPHQCVCYSAVSVLNCE (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022277"
SQ SEQUENCE 167 AA; 18250 MW; 8159F69DBEBF1F47 CRC64;
MDKLTIISGC LFLAADIFAI ASIANPDWIN TGESAGALTV GLVRQCQTIH GRDRTCIPPR
LPPEWVTTLF FIIMGIISLT VTCGLLVASH WRREATKYAR WIAFTGMILF CMAALIFPIG
FYINEVGGQP YKLPNNTVVG SSYVLFVLSI FFTIVGLLFA GKVCLPG
