ID   MOST1_HUMAN             Reviewed;          99 AA.
AC   Q9NRJ1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Protein MOST-1;
GN   Name=C8orf17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12665628; DOI=10.1136/mp.56.2.109;
RA   Tan J.M.M., Tock E.P.C., Chow V.T.K.;
RT   "The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression,
RT   maps to chromosome 8q24.2, and is overexpressed/amplified in high grade
RT   cancers of the breast and prostate.";
RL   Mol. Pathol. 56:109-115(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH TSPO; IGHM AND IGHD.
RX   PubMed=17143515;
RA   Tan J.M.M., Chow V.T.K.;
RT   "Cellular expression, localization and interactions of the product of the
RT   human MOST-1 gene associated with breast and prostate cancers.";
RL   Int. J. Oncol. 30:81-89(2007).
CC   -!- FUNCTION: May be involved in cell survival, proliferation and
CC       progression of cancer cells. {ECO:0000269|PubMed:12665628}.
CC   -!- SUBUNIT: Interacts with TSPO, IGHM and IGHD.
CC       {ECO:0000269|PubMed:17143515}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17143515}.
CC       Microsome membrane {ECO:0000269|PubMed:17143515}. Endoplasmic reticulum
CC       membrane {ECO:0000269|PubMed:17143515}.
CC   -!- TISSUE SPECIFICITY: Expressed in the heart, kidney, liver, pancreas,
CC       small intestine, ovary, testis, prostate and thymus. Expressed in all
CC       of the cancer cell lines tested. {ECO:0000269|PubMed:12665628}.
CC   -!- CAUTION: Encoded in an intron of the TRAPPC9 gene. {ECO:0000305}.
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DR   EMBL; AF220264; AAF87328.1; -; mRNA.
DR   EMBL; CH471060; EAW92204.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NRJ1; -.
DR   BioMuta; HGNC:17737; -.
DR   PaxDb; Q9NRJ1; -.
DR   PRIDE; Q9NRJ1; -.
DR   GeneCards; C8orf17; -.
DR   HGNC; HGNC:17737; C8orf17.
DR   MIM; 616992; gene.
DR   neXtProt; NX_Q9NRJ1; -.
DR   InParanoid; Q9NRJ1; -.
DR   PhylomeDB; Q9NRJ1; -.
DR   TreeFam; TF351561; -.
DR   PathwayCommons; Q9NRJ1; -.
DR   Pharos; Q9NRJ1; Tdark.
DR   PRO; PR:Q9NRJ1; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9NRJ1; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; NAS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Microsome; Reference proteome.
FT   CHAIN           1..99
FT                   /note="Protein MOST-1"
FT                   /id="PRO_0000331456"
FT   VARIANT         19
FT                   /note="T -> M (in dbSNP:rs2233233)"
FT                   /id="VAR_042878"
FT   VARIANT         49
FT                   /note="K -> R (in dbSNP:rs2233235)"
FT                   /id="VAR_042879"
FT   VARIANT         57
FT                   /note="T -> I (in dbSNP:rs2233236)"
FT                   /id="VAR_042880"
SQ   SEQUENCE   99 AA;  11219 MW;  29768671630A8D65 CRC64;
     MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV
     EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW