MOS_HUMAN
ID MOS_HUMAN Reviewed; 346 AA.
AC P00540; Q3KPG9; Q3KPH0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 196.
DE RecName: Full=Proto-oncogene serine/threonine-protein kinase mos {ECO:0000305};
DE EC=2.7.11.1;
DE AltName: Full=Oocyte maturation factor mos;
DE AltName: Full=Proto-oncogene c-Mos;
GN Name=MOS {ECO:0000312|HGNC:HGNC:7199};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=6287464; DOI=10.1073/pnas.79.13.4078;
RA Watson R., Oskarsson M., Vande Woude G.F.;
RT "Human DNA sequence homologous to the transforming gene (mos) of Moloney
RT murine sarcoma virus.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-105.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.
RX PubMed=17344846; DOI=10.1038/nature05610;
RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA Futreal P.A., Stratton M.R.;
RT "Patterns of somatic mutation in human cancer genomes.";
RL Nature 446:153-158(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- INTERACTION:
CC P00540; P35609: ACTN2; NbExp=3; IntAct=EBI-1757866, EBI-77797;
CC P00540; Q9NWX5: ASB6; NbExp=3; IntAct=EBI-1757866, EBI-6425205;
CC P00540; Q8WXE1: ATRIP; NbExp=3; IntAct=EBI-1757866, EBI-747353;
CC P00540; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-1757866, EBI-11975051;
CC P00540; Q96GS4: BORCS6; NbExp=4; IntAct=EBI-1757866, EBI-10193358;
CC P00540; Q13137: CALCOCO2; NbExp=8; IntAct=EBI-1757866, EBI-739580;
CC P00540; Q8NA61: CBY2; NbExp=3; IntAct=EBI-1757866, EBI-741724;
CC P00540; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-1757866, EBI-11524851;
CC P00540; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-1757866, EBI-10171570;
CC P00540; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-1757866, EBI-10171416;
CC P00540; O95273: CCNDBP1; NbExp=3; IntAct=EBI-1757866, EBI-748961;
CC P00540; Q16543: CDC37; NbExp=2; IntAct=EBI-1757866, EBI-295634;
CC P00540; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-1757866, EBI-740680;
CC P00540; Q86YF9: DZIP1; NbExp=3; IntAct=EBI-1757866, EBI-998108;
CC P00540; Q13451: FKBP5; NbExp=3; IntAct=EBI-1757866, EBI-306914;
CC P00540; P14136: GFAP; NbExp=3; IntAct=EBI-1757866, EBI-744302;
CC P00540; Q08379: GOLGA2; NbExp=6; IntAct=EBI-1757866, EBI-618309;
CC P00540; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-1757866, EBI-11163335;
CC P00540; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1757866, EBI-5916454;
CC P00540; O75791: GRAP2; NbExp=3; IntAct=EBI-1757866, EBI-740418;
CC P00540; Q9NSC5: HOMER3; NbExp=8; IntAct=EBI-1757866, EBI-748420;
CC P00540; P07900: HSP90AA1; NbExp=2; IntAct=EBI-1757866, EBI-296047;
CC P00540; P08238: HSP90AB1; NbExp=2; IntAct=EBI-1757866, EBI-352572;
CC P00540; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-1757866, EBI-11522367;
CC P00540; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-1757866, EBI-2511344;
CC P00540; Q92845: KIFAP3; NbExp=3; IntAct=EBI-1757866, EBI-954040;
CC P00540; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-1757866, EBI-2125614;
CC P00540; A1A4E9: KRT13; NbExp=3; IntAct=EBI-1757866, EBI-10171552;
CC P00540; P19012: KRT15; NbExp=6; IntAct=EBI-1757866, EBI-739566;
CC P00540; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-1757866, EBI-3044087;
CC P00540; Q15323: KRT31; NbExp=3; IntAct=EBI-1757866, EBI-948001;
CC P00540; Q14525: KRT33B; NbExp=3; IntAct=EBI-1757866, EBI-1049638;
CC P00540; O76011: KRT34; NbExp=3; IntAct=EBI-1757866, EBI-1047093;
CC P00540; Q6A162: KRT40; NbExp=3; IntAct=EBI-1757866, EBI-10171697;
CC P00540; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-1757866, EBI-11749135;
CC P00540; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-1757866, EBI-741037;
CC P00540; P36507: MAP2K2; NbExp=3; IntAct=EBI-1757866, EBI-1056930;
CC P00540; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1757866, EBI-16439278;
CC P00540; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-1757866, EBI-10172526;
CC P00540; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-1757866, EBI-2548751;
CC P00540; Q96QG7: MTMR9; NbExp=6; IntAct=EBI-1757866, EBI-744593;
CC P00540; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-1757866, EBI-11522433;
CC P00540; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-1757866, EBI-22310682;
CC P00540; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1757866, EBI-79165;
CC P00540; Q15172: PPP2R5A; NbExp=5; IntAct=EBI-1757866, EBI-641666;
CC P00540; O43586: PSTPIP1; NbExp=3; IntAct=EBI-1757866, EBI-1050964;
CC P00540; P53992: SEC24C; NbExp=4; IntAct=EBI-1757866, EBI-81134;
CC P00540; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-1757866, EBI-2212028;
CC P00540; Q9UNE7: STUB1; NbExp=2; IntAct=EBI-1757866, EBI-357085;
CC P00540; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-1757866, EBI-11952721;
CC P00540; Q13077: TRAF1; NbExp=6; IntAct=EBI-1757866, EBI-359224;
CC P00540; Q12933: TRAF2; NbExp=3; IntAct=EBI-1757866, EBI-355744;
CC P00540; P14373: TRIM27; NbExp=3; IntAct=EBI-1757866, EBI-719493;
CC P00540; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-1757866, EBI-739895;
CC P00540; Q8N680: ZBTB2; NbExp=3; IntAct=EBI-1757866, EBI-2515601;
CC -!- TISSUE SPECIFICITY: Expressed specifically in testis during
CC spermatogenesis.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; J00119; AAA52029.1; -; Genomic_DNA.
DR EMBL; BC069569; AAH69569.1; -; mRNA.
DR EMBL; BC069590; AAH69590.1; -; mRNA.
DR EMBL; BC106737; AAI06738.1; -; mRNA.
DR EMBL; BC106738; AAI06739.1; -; mRNA.
DR CCDS; CCDS6164.1; -.
DR PIR; A00649; TVHUMS.
DR RefSeq; NP_005363.1; NM_005372.1.
DR AlphaFoldDB; P00540; -.
DR SMR; P00540; -.
DR BioGRID; 110483; 68.
DR IntAct; P00540; 83.
DR MINT; P00540; -.
DR STRING; 9606.ENSP00000310722; -.
DR ChEMBL; CHEMBL1075184; -.
DR iPTMnet; P00540; -.
DR PhosphoSitePlus; P00540; -.
DR BioMuta; MOS; -.
DR DMDM; 125497; -.
DR MassIVE; P00540; -.
DR PaxDb; P00540; -.
DR PeptideAtlas; P00540; -.
DR PRIDE; P00540; -.
DR ProteomicsDB; 51265; -.
DR Antibodypedia; 24550; 297 antibodies from 27 providers.
DR DNASU; 4342; -.
DR Ensembl; ENST00000311923.1; ENSP00000310722.1; ENSG00000172680.1.
DR GeneID; 4342; -.
DR KEGG; hsa:4342; -.
DR MANE-Select; ENST00000311923.1; ENSP00000310722.1; NM_005372.1; NP_005363.1.
DR UCSC; uc011leb.2; human.
DR CTD; 4342; -.
DR DisGeNET; 4342; -.
DR GeneCards; MOS; -.
DR HGNC; HGNC:7199; MOS.
DR HPA; ENSG00000172680; Not detected.
DR MIM; 190060; gene.
DR neXtProt; NX_P00540; -.
DR OpenTargets; ENSG00000172680; -.
DR PharmGKB; PA30907; -.
DR VEuPathDB; HostDB:ENSG00000172680; -.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000160233; -.
DR HOGENOM; CLU_000288_7_35_1; -.
DR InParanoid; P00540; -.
DR OMA; ITREQPY; -.
DR OrthoDB; 993493at2759; -.
DR PhylomeDB; P00540; -.
DR TreeFam; TF331103; -.
DR BRENDA; 2.7.10.2; 2681.
DR PathwayCommons; P00540; -.
DR SignaLink; P00540; -.
DR SIGNOR; P00540; -.
DR BioGRID-ORCS; 4342; 17 hits in 1107 CRISPR screens.
DR GeneWiki; MOS_(gene); -.
DR GenomeRNAi; 4342; -.
DR Pharos; P00540; Tbio.
DR PRO; PR:P00540; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; P00540; protein.
DR Bgee; ENSG00000172680; Expressed in oocyte and 13 other tissues.
DR Genevisible; P00540; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; ISS:UniProtKB.
DR GO; GO:0051296; P:establishment of meiotic spindle orientation; ISS:UniProtKB.
DR GO; GO:0000165; P:MAPK cascade; ISS:UniProtKB.
DR GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR GO; GO:1902103; P:negative regulation of metaphase/anaphase transition of meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR GO; GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
DR GO; GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Kinase; Nucleotide-binding; Proto-oncogene;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..346
FT /note="Proto-oncogene serine/threonine-protein kinase mos"
FT /id="PRO_0000086344"
FT DOMAIN 60..341
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 201
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 66..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 87
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT VARIANT 96
FT /note="R -> L (in dbSNP:rs34532635)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040813"
FT VARIANT 105
FT /note="A -> S (in dbSNP:rs35392772)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17344846"
FT /id="VAR_040814"
FT VARIANT 123
FT /note="A -> T (in a lung adenocarcinoma sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040815"
FT VARIANT 300
FT /note="S -> P (in dbSNP:rs56300224)"
FT /evidence="ECO:0000269|PubMed:17344846"
FT /id="VAR_040816"
SQ SEQUENCE 346 AA; 37820 MW; 68B1AB906ED4B308 CRC64;
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV
CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV
VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK
YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG
GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
