MOS_PIG
ID MOS_PIG Reviewed; 345 AA.
AC P50118;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Proto-oncogene serine/threonine-protein kinase mos {ECO:0000250|UniProtKB:P00540};
DE EC=2.7.11.1;
DE AltName: Full=Oocyte maturation factor mos;
DE AltName: Full=Proto-oncogene c-Mos;
GN Name=MOS {ECO:0000250|UniProtKB:P00540};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8858597;
RX DOI=10.1002/(sici)1098-2795(199607)44:3<275::aid-mrd1>3.0.co;2-j;
RA Newman B., Dai Y.;
RT "Transcription of c-mos protooncogene in the pig involves both tissue-
RT specific promoters and alternative polyadenylation sites.";
RL Mol. Reprod. Dev. 44:275-288(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- TISSUE SPECIFICITY: Restricted to gonadal tissues.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; X78318; CAA55124.1; -; Genomic_DNA.
DR PIR; S43124; S43124.
DR RefSeq; NP_001106690.1; NM_001113219.1.
DR AlphaFoldDB; P50118; -.
DR SMR; P50118; -.
DR STRING; 9823.ENSSSCP00000006661; -.
DR PaxDb; P50118; -.
DR PRIDE; P50118; -.
DR Ensembl; ENSSSCT00000006847; ENSSSCP00000006661; ENSSSCG00000006248.
DR Ensembl; ENSSSCT00005017682; ENSSSCP00005010569; ENSSSCG00005011465.
DR Ensembl; ENSSSCT00015083319; ENSSSCP00015033717; ENSSSCG00015062389.
DR Ensembl; ENSSSCT00025029719; ENSSSCP00025012643; ENSSSCG00025021845.
DR Ensembl; ENSSSCT00030059487; ENSSSCP00030027229; ENSSSCG00030042704.
DR Ensembl; ENSSSCT00035055230; ENSSSCP00035022211; ENSSSCG00035041576.
DR Ensembl; ENSSSCT00040031368; ENSSSCP00040013048; ENSSSCG00040023423.
DR Ensembl; ENSSSCT00045033223; ENSSSCP00045023027; ENSSSCG00045019514.
DR Ensembl; ENSSSCT00055050924; ENSSSCP00055040712; ENSSSCG00055025768.
DR Ensembl; ENSSSCT00060087118; ENSSSCP00060037692; ENSSSCG00060063857.
DR Ensembl; ENSSSCT00065110114; ENSSSCP00065049575; ENSSSCG00065079211.
DR Ensembl; ENSSSCT00070007703; ENSSSCP00070006327; ENSSSCG00070004101.
DR GeneID; 100127484; -.
DR KEGG; ssc:100127484; -.
DR CTD; 4342; -.
DR VGNC; VGNC:90312; MOS.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000160233; -.
DR HOGENOM; CLU_000288_7_35_1; -.
DR InParanoid; P50118; -.
DR OMA; CKFASGR; -.
DR OrthoDB; 993493at2759; -.
DR TreeFam; TF331103; -.
DR BRENDA; 2.7.10.2; 6170.
DR Proteomes; UP000008227; Chromosome 4.
DR Proteomes; UP000314985; Chromosome 4.
DR Bgee; ENSSSCG00000006248; Expressed in oocyte and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; ISS:UniProtKB.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IMP:AgBase.
DR GO; GO:0051296; P:establishment of meiotic spindle orientation; ISS:UniProtKB.
DR GO; GO:0000165; P:MAPK cascade; IMP:AgBase.
DR GO; GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.
DR GO; GO:1902103; P:negative regulation of metaphase/anaphase transition of meiotic cell cycle; IMP:AgBase.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR GO; GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
DR GO; GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Proto-oncogene;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..345
FT /note="Proto-oncogene serine/threonine-protein kinase mos"
FT /id="PRO_0000086346"
FT DOMAIN 63..344
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 202
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 69..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 345 AA; 37941 MW; 81FE48667FB06751 CRC64;
MPSPFPRRRC LPGDFSPSVD SRPCSSPCEL PGPTGKLFLG GTPPRALRLP RRLAWCSIDW
EQVCLLQRLG AGGFGSVYKA TYHGVPVAIK QVSRCTKNRL ASQRSFWAEL NIARLRHANI
VRVVAASTRT PAAFDSLGSI IMEFGGNVTL HQVIYGATGC PEEDGPPCSA GEQLNLEKCL
KYSLDVVSGL LFLHSQGIVH LDLKPANILI SEQDVCKISD FGCSERLEDL RFRPRHHLGG
TYTHRAPELL KGEPVTPKAD IYSFAITLWQ MTTRQVPYSG ERQHVLYAVV AYNLRPSLSA
AVFTESVPGK KLEDIIQCGW TAPAQQRPSA QLLLLDLRAL QAELG
