MOT11_MOUSE
ID MOT11_MOUSE Reviewed; 447 AA.
AC Q5NC32; A2BDD4; Q5NC33;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Monocarboxylate transporter 11;
DE Short=MCT 11;
DE AltName: Full=Solute carrier family 16 member 11;
GN Name=Slc16a11; Synonyms=Mct11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-421.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. It catalyzes the
CC transport of pyruvate across the plasma membrane. Probably involved in
CC hepatic lipid metabolism: overexpression results in an increase of
CC triacylglycerol(TAG) levels, small increases in intracellular
CC diacylglycerols and decreases in lysophosphatidylcholine, cholesterol
CC ester and sphingomyelin lipids. {ECO:0000250|UniProtKB:Q8NCK7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in);
CC Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000250|UniProtKB:Q8NCK7};
CC -!- SUBUNIT: Interacts with isoform 2 of BSG.
CC {ECO:0000250|UniProtKB:Q8NCK7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8NCK7}; Multi-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8NCK7}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI30256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAI35219.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM28086.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL669869; CAI35219.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL669869; CAI35220.1; -; Genomic_DNA.
DR EMBL; CR933731; CAM28086.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR933731; CAM28087.1; -; Genomic_DNA.
DR EMBL; BC130255; AAI30256.1; ALT_INIT; mRNA.
DR RefSeq; NP_694721.2; NM_153081.3.
DR RefSeq; XP_006532979.1; XM_006532916.2.
DR RefSeq; XP_011247226.1; XM_011248924.2.
DR AlphaFoldDB; Q5NC32; -.
DR SMR; Q5NC32; -.
DR STRING; 10090.ENSMUSP00000116648; -.
DR PhosphoSitePlus; Q5NC32; -.
DR PaxDb; Q5NC32; -.
DR PRIDE; Q5NC32; -.
DR ProteomicsDB; 291484; -.
DR Antibodypedia; 53202; 116 antibodies from 21 providers.
DR DNASU; 216867; -.
DR Ensembl; ENSMUST00000094055; ENSMUSP00000091597; ENSMUSG00000040938.
DR Ensembl; ENSMUST00000126388; ENSMUSP00000116648; ENSMUSG00000040938.
DR Ensembl; ENSMUST00000171032; ENSMUSP00000128419; ENSMUSG00000040938.
DR GeneID; 216867; -.
DR KEGG; mmu:216867; -.
DR UCSC; uc007jua.2; mouse.
DR CTD; 162515; -.
DR MGI; MGI:2663709; Slc16a11.
DR VEuPathDB; HostDB:ENSMUSG00000040938; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000162017; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q5NC32; -.
DR OMA; RIMNGIS; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q5NC32; -.
DR TreeFam; TF313792; -.
DR BioGRID-ORCS; 216867; 0 hits in 65 CRISPR screens.
DR ChiTaRS; Slc16a11; mouse.
DR PRO; PR:Q5NC32; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5NC32; protein.
DR Bgee; ENSMUSG00000040938; Expressed in cerebellar cortex and 85 other tissues.
DR ExpressionAtlas; Q5NC32; baseline and differential.
DR Genevisible; Q5NC32; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; ISS:UniProtKB.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR030769; MCT11.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360:SF80; PTHR11360:SF80; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endoplasmic reticulum; Lipid metabolism; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..447
FT /note="Monocarboxylate transporter 11"
FT /id="PRO_0000286674"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..447
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 447 AA; 45235 MW; DEDD0C70314FAFD8 CRC64;
MTPKPAGPPD GGWGWVVAAA AFAVNGLSYG LLRSLGLALP DLAEHFERSA QDTAWVSALA
LAVQQAASPV GSALSTRWGA RPVVMVGGVL TSLGLVFSAF ARSLLHLYLG LGLLAGSGWA
LVFAPALGTL SRYFSRRRVL AVGLALTGNG ASSLLLAPAL QFLLDTFGWR GALLLLGAVT
LHLTPCGALL RPLALSGDPL APPRTPLAAL GLGLFKRRAF SVFALGTALI GGGYFVPYVH
LGPHALDQGM GGYGAALVVA VAAVGDACAR LASGWLADQG WVPLPRLLVV FGSLTGLGVL
AMGLVPTVGT EEGWGAPLLA AAGAYGLSAG SYAPLVFGVL PGLVGIGGVV QATGLVMMLM
SLGGLLGPPL SGFLRDKTGD FSASFLVCSS FILSGSFIYM GLPRALPSCR PASPPATPPP
ERGELLPVPQ VSLLSAGGTG SIRDTTC
