ID   MOT12_XENLA             Reviewed;         460 AA.
AC   Q6GM59;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Monocarboxylate transporter 12 {ECO:0000305};
DE            Short=MCT 12 {ECO:0000305};
DE   AltName: Full=Solute carrier family 16 member 12;
GN   Name=slc16a12;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-linked monocarboxylate transporter that mediates
CC       creatine transport across the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q6ZSM3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; BC074222; AAH74222.1; -; mRNA.
DR   RefSeq; NP_001086124.1; NM_001092655.1.
DR   AlphaFoldDB; Q6GM59; -.
DR   SMR; Q6GM59; -.
DR   DNASU; 444553; -.
DR   GeneID; 444553; -.
DR   KEGG; xla:444553; -.
DR   CTD; 444553; -.
DR   Xenbase; XB-GENE-1012790; slc16a12.S.
DR   OrthoDB; 916876at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 444553; Expressed in kidney and 15 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005308; F:creatine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0015881; P:creatine transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Monocarboxylate transporter 12"
FT                   /id="PRO_0000286967"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        427..460
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  50337 MW;  EFF80572840A3626 CRC64;
     MTQEKRSLHK TPPDGGWGWM IVIGCFFVTV CTRAVTRCIS IFFVEFQSYF AQDYARTAWI
     HSIVDCSTML CAPIGSYVSN HFSCQVGIIL GGVLASTGLV LSSFATSLEY LYLTLGVLTG
     LGFALCYSPA IAMVGKYFEK RKALAYGIAM SGSGIGTFIL APVVQLLIEQ FSWRGALLIL
     GGFVSNLCVC GALMRPISLK EDSLHYPLKR EPQLDSSCSP LCQDCSHKKL CYCTTKEYHF
     LLKPKFIILA VSFLFLAYGC SPPFVYLVPY SLSVGVSHQE AAFLMSILGI VDIVGNITFG
     WVTDRRFLKK HRYCCYLIAV GLDGLCCLFL PILTCFQLLV PFSVMFGYFD GAYVALIPVI
     TGDVVGTSNL SSALGVVFFL HAVPYLLSPP IAGWLVDTTG DYTAAFLLSG FSMIFCSILL
     GLAKIINRIK KNPQATVVRS SDIKQEVWTN GDVSCLNAIS