ID   MOT12_XENTR             Reviewed;         473 AA.
AC   Q6P2X9; Q28D48;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Monocarboxylate transporter 12 {ECO:0000305};
DE            Short=MCT 12 {ECO:0000305};
DE   AltName: Full=Solute carrier family 16 member 12;
GN   Name=slc16a12; ORFNames=TGas051g14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-linked monocarboxylate transporter that mediates
CC       creatine transport across the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q6ZSM3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ83777.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR855712; CAJ83777.1; ALT_INIT; mRNA.
DR   EMBL; BC064255; AAH64255.1; -; mRNA.
DR   RefSeq; NP_989310.1; NM_203979.1.
DR   AlphaFoldDB; Q6P2X9; -.
DR   SMR; Q6P2X9; -.
DR   DNASU; 394932; -.
DR   GeneID; 394932; -.
DR   KEGG; xtr:394932; -.
DR   CTD; 387700; -.
DR   Xenbase; XB-GENE-1012784; slc16a12.
DR   InParanoid; Q6P2X9; -.
DR   OrthoDB; 916876at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005308; F:creatine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0015881; P:creatine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..473
FT                   /note="Monocarboxylate transporter 12"
FT                   /id="PRO_0000286968"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        436..473
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   473 AA;  51742 MW;  A378FA46833E525A CRC64;
     MTQEKRNLHK APPDGGWGWM IVIGCFFVTV CTRAVTRCIS IFFVEFQSYF AQDYARTAWI
     HSIVDCSTML CAPIGSYVSN HFSCQVGIIL GGVLASTGLV LSSFATSLEY LYLTLGVLTG
     LGFALCYSPA IAMVGKYFEK RKALAYGIAM SGSGIGTFIL APVVQLLIEQ FSWRGALLIL
     GGFVSNLCVC GALMRPITLK EDSLHYPLKQ EQMENEPTQS GRLDSSCSPL CQDCSHKRLC
     YCTKKEYSFL LKPKFMVLAV SFLFLAYGCS PPFVYLVPYA LNVGVSNQEA AFLMSILGII
     DIVGNITFGW VTDTRFLKKH RYCCYLIAVG LDGLCCLFLP ILTRFQLLVP FSVMFGYFDG
     AYVALIPVVT GDVVGTSSLS SALGVVFFLH AVPYLVSPPI AGWLVDTTGD YTAAFLLSGF
     SMIFCAVLLA LAKIINRIKK RPKAVAVPTS DIKQEIWTNG DVSCANAINQ KEV