MOT13_BOVIN
ID MOT13_BOVIN Reviewed; 426 AA.
AC Q17QR6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Monocarboxylate transporter 13;
DE Short=MCT 13;
DE AltName: Full=Solute carrier family 16 member 13;
GN Name=SLC16A13; Synonyms=MCT13;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250|UniProtKB:Q7RTY0}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q7RTY0}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q7RTY0}. Cell membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR EMBL; BC118219; AAI18220.1; -; mRNA.
DR RefSeq; NP_001069600.1; NM_001076132.1.
DR AlphaFoldDB; Q17QR6; -.
DR SMR; Q17QR6; -.
DR STRING; 9913.ENSBTAP00000027786; -.
DR PaxDb; Q17QR6; -.
DR PRIDE; Q17QR6; -.
DR Ensembl; ENSBTAT00000027786; ENSBTAP00000027786; ENSBTAG00000020853.
DR GeneID; 538855; -.
DR KEGG; bta:538855; -.
DR CTD; 201232; -.
DR VEuPathDB; HostDB:ENSBTAG00000020853; -.
DR VGNC; VGNC:34687; SLC16A13.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000159372; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q17QR6; -.
DR OMA; YGMTEVQ; -.
DR OrthoDB; 916876at2759; -.
DR TreeFam; TF313792; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000020853; Expressed in liver and 101 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..426
FT /note="Monocarboxylate transporter 13"
FT /id="PRO_0000287186"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 426 AA; 44713 MW; 4F5901D183B048C5 CRC64;
MAYRAEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEPAA RVSWIASIGI
AVQQFGSPVG SALSTKFGPR PAVMTGGILT ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
TFTPTLACLS RYFSRRRSLA MGLALTGVGL SSFAFAPLFQ WLLNHYAWRG ALLLVSALSL
HLVACGALLR PLSLAEDPVV GGPGAQITSL LRHGPFLRYT VALTLINTGY FIPYVHLVAH
LRDLGWDPLP AAFLLSVAAI SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVILALYPV
AEAPTGLVAL TMAYGFTSGA LTPVAFSVLP ELVGTGKIYC GLGLVQMVES IGGLLGAPLS
GYLRDVTGNY TASFVVAGAF LLAGSGVLIT LPHFFCFSAP TSKPQDLVTE ALDTKVPLPE
EGLGED