MOT13_HUMAN
ID MOT13_HUMAN Reviewed; 426 AA.
AC Q7RTY0; A3KMG3; A5PKU5; Q2VP92;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Monocarboxylate transporter 13;
DE Short=MCT 13;
DE AltName: Full=Solute carrier family 16 member 13;
GN Name=SLC16A13; Synonyms=MCT13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=12739169; DOI=10.1007/s00424-003-1067-2;
RA Halestrap A.P., Meredith D.;
RT "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic
RT amino acid transporters and beyond.";
RL Pflugers Arch. 447:619-628(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND INVOLVEMENT IN NIDDM.
RX PubMed=24390345; DOI=10.1038/nature12828;
RG The SIGMA Type 2 Diabetes Consortium;
RT "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes
RT in Mexico.";
RL Nature 506:97-101(2014).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000305|PubMed:12739169}.
CC -!- INTERACTION:
CC Q7RTY0; Q13520: AQP6; NbExp=3; IntAct=EBI-12243266, EBI-13059134;
CC Q7RTY0; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-12243266, EBI-12069500;
CC Q7RTY0; P35613-2: BSG; NbExp=3; IntAct=EBI-12243266, EBI-11037868;
CC Q7RTY0; O95273: CCNDBP1; NbExp=3; IntAct=EBI-12243266, EBI-748961;
CC Q7RTY0; P11912: CD79A; NbExp=3; IntAct=EBI-12243266, EBI-7797864;
CC Q7RTY0; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12243266, EBI-6942903;
CC Q7RTY0; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-12243266, EBI-18938272;
CC Q7RTY0; P48165: GJA8; NbExp=3; IntAct=EBI-12243266, EBI-17458373;
CC Q7RTY0; P14060: HSD3B1; NbExp=3; IntAct=EBI-12243266, EBI-17426018;
CC Q7RTY0; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-12243266, EBI-465137;
CC Q7RTY0; O15173: PGRMC2; NbExp=3; IntAct=EBI-12243266, EBI-1050125;
CC Q7RTY0; P43378: PTPN9; NbExp=3; IntAct=EBI-12243266, EBI-742898;
CC Q7RTY0; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-12243266, EBI-18037857;
CC Q7RTY0; Q14973: SLC10A1; NbExp=3; IntAct=EBI-12243266, EBI-3923031;
CC Q7RTY0; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-12243266, EBI-726331;
CC Q7RTY0; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12243266, EBI-8638294;
CC Q7RTY0; Q9NX00: TMEM160; NbExp=3; IntAct=EBI-12243266, EBI-2514588;
CC Q7RTY0; P56557: TMEM50B; NbExp=3; IntAct=EBI-12243266, EBI-12366453;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:24390345}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:24390345}. Cell membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISEASE: Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]:
CC A multifactorial disorder of glucose homeostasis caused by a lack of
CC sensitivity to the body's own insulin. Affected individuals usually
CC have an obese body habitus and manifestations of a metabolic syndrome
CC characterized by diabetes, insulin resistance, hypertension and
CC hypertriglyceridemia. The disease results in long-term complications
CC that affect the eyes, kidneys, nerves, and blood vessels.
CC {ECO:0000269|PubMed:24390345}. Note=Disease susceptibility is
CC associated with variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH471108; EAW90272.1; -; Genomic_DNA.
DR EMBL; BC109286; AAI09287.1; -; mRNA.
DR EMBL; BC131739; AAI31740.1; -; mRNA.
DR EMBL; BC142618; AAI42619.1; -; mRNA.
DR EMBL; BN000145; CAD80156.1; -; mRNA.
DR CCDS; CCDS11085.1; -.
DR RefSeq; NP_963860.1; NM_201566.2.
DR AlphaFoldDB; Q7RTY0; -.
DR SMR; Q7RTY0; -.
DR BioGRID; 128373; 28.
DR IntAct; Q7RTY0; 20.
DR STRING; 9606.ENSP00000309751; -.
DR TCDB; 2.A.1.13.17; the major facilitator superfamily (mfs).
DR iPTMnet; Q7RTY0; -.
DR PhosphoSitePlus; Q7RTY0; -.
DR BioMuta; SLC16A13; -.
DR DMDM; 74723222; -.
DR MassIVE; Q7RTY0; -.
DR PaxDb; Q7RTY0; -.
DR PeptideAtlas; Q7RTY0; -.
DR PRIDE; Q7RTY0; -.
DR ProteomicsDB; 68930; -.
DR Antibodypedia; 58703; 105 antibodies from 22 providers.
DR DNASU; 201232; -.
DR Ensembl; ENST00000308027.7; ENSP00000309751.6; ENSG00000174327.7.
DR GeneID; 201232; -.
DR KEGG; hsa:201232; -.
DR MANE-Select; ENST00000308027.7; ENSP00000309751.6; NM_201566.3; NP_963860.1.
DR UCSC; uc002geh.3; human.
DR CTD; 201232; -.
DR DisGeNET; 201232; -.
DR GeneCards; SLC16A13; -.
DR HGNC; HGNC:31037; SLC16A13.
DR HPA; ENSG00000174327; Tissue enhanced (liver).
DR MIM; 125853; phenotype.
DR neXtProt; NX_Q7RTY0; -.
DR OpenTargets; ENSG00000174327; -.
DR PharmGKB; PA134991782; -.
DR VEuPathDB; HostDB:ENSG00000174327; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000159372; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q7RTY0; -.
DR OMA; YGMTEVQ; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q7RTY0; -.
DR TreeFam; TF313792; -.
DR PathwayCommons; Q7RTY0; -.
DR SignaLink; Q7RTY0; -.
DR BioGRID-ORCS; 201232; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; SLC16A13; human.
DR GenomeRNAi; 201232; -.
DR Pharos; Q7RTY0; Tbio.
DR PRO; PR:Q7RTY0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q7RTY0; protein.
DR Bgee; ENSG00000174327; Expressed in right lobe of liver and 96 other tissues.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Diabetes mellitus; Golgi apparatus; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..426
FT /note="Monocarboxylate transporter 13"
FT /id="PRO_0000287187"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 44992 MW; 6A6849507C933624 CRC64;
MARRTEPPDG GWGWVVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA RVSWIASIGI
AVQQFGSPVG SALSTKFGPR PVVMTGGILA ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
TFAPTLACLS CYFSRRRSLA TGLALTGVGL SSFTFAPFFQ WLLSHYAWRG SLLLVSALSL
HLVACGALLR PPSLAEDPAV GGPRAQLTSL LHHGPFLRYT VALTLINTGY FIPYLHLVAH
LQDLDWDPLP AAFLLSVVAI SDLVGRVVSG WLGDAVPGPV TRLLMLWTTL TGVSLALFPV
AQAPTALVAL AVAYGFTSGA LAPLAFSVLP ELIGTRRIYC GLGLLQMIES IGGLLGPPLS
GYLRDVTGNY TASFVVAGAF LLSGSGILLT LPHFFCFSTT TSGPQDLVTE ALDTKVPLPK
EGLEED
