MOT13_MOUSE
ID MOT13_MOUSE Reviewed; 428 AA.
AC Q8CE94; Q8CEH6; Q8CF46;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Monocarboxylate transporter 13;
DE Short=MCT 13;
DE AltName: Full=Solute carrier family 16 member 13;
GN Name=Slc16a13; Synonyms=Mct13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250|UniProtKB:Q7RTY0}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q7RTY0}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q7RTY0}. Cell membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25120.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK005699; BAC25120.1; ALT_INIT; mRNA.
DR EMBL; AK028143; BAC25771.1; -; mRNA.
DR EMBL; AK028759; BAC26104.1; -; mRNA.
DR EMBL; AL669869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039949; AAH39949.1; -; mRNA.
DR CCDS; CCDS24938.1; -.
DR RefSeq; NP_758959.1; NM_172371.3.
DR AlphaFoldDB; Q8CE94; -.
DR SMR; Q8CE94; -.
DR STRING; 10090.ENSMUSP00000053218; -.
DR PhosphoSitePlus; Q8CE94; -.
DR PaxDb; Q8CE94; -.
DR PeptideAtlas; Q8CE94; -.
DR PRIDE; Q8CE94; -.
DR ProteomicsDB; 290279; -.
DR Antibodypedia; 58703; 105 antibodies from 22 providers.
DR DNASU; 69309; -.
DR Ensembl; ENSMUST00000060010; ENSMUSP00000053218; ENSMUSG00000044367.
DR GeneID; 69309; -.
DR KEGG; mmu:69309; -.
DR UCSC; uc007jub.1; mouse.
DR CTD; 201232; -.
DR MGI; MGI:1916559; Slc16a13.
DR VEuPathDB; HostDB:ENSMUSG00000044367; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000159372; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q8CE94; -.
DR OMA; YGMTEVQ; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q8CE94; -.
DR TreeFam; TF313792; -.
DR BioGRID-ORCS; 69309; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Slc16a13; mouse.
DR PRO; PR:Q8CE94; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8CE94; protein.
DR Bgee; ENSMUSG00000044367; Expressed in proximal tubule and 145 other tissues.
DR ExpressionAtlas; Q8CE94; baseline and differential.
DR Genevisible; Q8CE94; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..428
FT /note="Monocarboxylate transporter 13"
FT /id="PRO_0000287188"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 54
FT /note="W -> C (in Ref. 1; BAC25771)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="S -> Y (in Ref. 1; BAC25771)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="Q -> H (in Ref. 1; BAC25771)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="S -> T (in Ref. 1; BAC25771)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="S -> N (in Ref. 1; BAC25120)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="R -> Q (in Ref. 1; BAC25120)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 44862 MW; C0EE724184856D45 CRC64;
MVRRAEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA RVSWIASIGI
AVQQFGSPIG SALSTKLGPR PVVMTGGILA ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
TFTPTMACLS RYFSQRRSLA MGLALTGVGI SSFAFAPLFQ WLINNYAWRG ALLLVSALSL
HLMACGALLR PLSLTEDAAV GGPGAQITSL LRHGPFLRYT AALTLINTGF FIPYVHLVAH
LQDLGWDPLP AAFLLSVAAV SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVSLALFPV
AQASSTLVVL AVAYGFTSGA LTPVAFSVLP ELVGTGRIYC GMGLVQMIES IGGLLGAPLS
GYLRDVTGNY TASFVVAGAF LLAGSGVLLT LPHFFSCISV STSRPQDLVI EASDTKIPLP
KEEGLGEN
