MOT13_RAT
ID MOT13_RAT Reviewed; 428 AA.
AC Q66HE2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Monocarboxylate transporter 13;
DE Short=MCT 13;
DE AltName: Full=Solute carrier family 16 member 13;
GN Name=Slc16a13; Synonyms=Mct13;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250|UniProtKB:Q7RTY0}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q7RTY0}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q7RTY0}. Cell membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR EMBL; BC081902; AAH81902.1; -; mRNA.
DR RefSeq; NP_001005530.1; NM_001005530.1.
DR AlphaFoldDB; Q66HE2; -.
DR SMR; Q66HE2; -.
DR STRING; 10116.ENSRNOP00000025403; -.
DR PaxDb; Q66HE2; -.
DR Ensembl; ENSRNOT00000025403; ENSRNOP00000025403; ENSRNOG00000018785.
DR GeneID; 287451; -.
DR KEGG; rno:287451; -.
DR UCSC; RGD:1359138; rat.
DR CTD; 201232; -.
DR RGD; 1359138; Slc16a13.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000159372; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q66HE2; -.
DR OMA; YGMTEVQ; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q66HE2; -.
DR TreeFam; TF313792; -.
DR PRO; PR:Q66HE2; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000018785; Expressed in adult mammalian kidney and 18 other tissues.
DR Genevisible; Q66HE2; RN.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..428
FT /note="Monocarboxylate transporter 13"
FT /id="PRO_0000287189"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 44993 MW; 7AC65745D23D3A79 CRC64;
MVHRTEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA RVSWIASIGI
AVQQFGSPIG SALSTKLGPR PVVMTGGILA ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
TFTPTLACLS RYFSQRRSLA MGLALTGVGI SSFAFAPLFQ WLLNNYAWRG ALLLVSALSL
HLVACGALLR PLSLTEDTAV GGPWAQITSL LCHGPFLRYT VALTLINTGY FIPYVHLVAH
LQDLGWDPLP AAFLLSVAAI SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVSLALFPV
AQASTTLVVL AVAYGFTSGA LTPVAFSVIP ELVGTGRIYC GLGLVQMIES VGGLLGAPLS
GYLRDVTGNY TASFVVAGAF LLAGSGVLIT LPHFFSCISL STSRPQDLVI EAPDTKIPLP
KEEGLGEN