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MOT13_RAT
ID   MOT13_RAT               Reviewed;         428 AA.
AC   Q66HE2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Monocarboxylate transporter 13;
DE            Short=MCT 13;
DE   AltName: Full=Solute carrier family 16 member 13;
GN   Name=Slc16a13; Synonyms=Mct13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC       transport of monocarboxylates across the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q7RTY0}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q7RTY0}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q7RTY0}. Cell membrane {ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; BC081902; AAH81902.1; -; mRNA.
DR   RefSeq; NP_001005530.1; NM_001005530.1.
DR   AlphaFoldDB; Q66HE2; -.
DR   SMR; Q66HE2; -.
DR   STRING; 10116.ENSRNOP00000025403; -.
DR   PaxDb; Q66HE2; -.
DR   Ensembl; ENSRNOT00000025403; ENSRNOP00000025403; ENSRNOG00000018785.
DR   GeneID; 287451; -.
DR   KEGG; rno:287451; -.
DR   UCSC; RGD:1359138; rat.
DR   CTD; 201232; -.
DR   RGD; 1359138; Slc16a13.
DR   eggNOG; KOG2504; Eukaryota.
DR   GeneTree; ENSGT00940000159372; -.
DR   HOGENOM; CLU_001265_59_1_1; -.
DR   InParanoid; Q66HE2; -.
DR   OMA; YGMTEVQ; -.
DR   OrthoDB; 916876at2759; -.
DR   PhylomeDB; Q66HE2; -.
DR   TreeFam; TF313792; -.
DR   PRO; PR:Q66HE2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000018785; Expressed in adult mammalian kidney and 18 other tissues.
DR   Genevisible; Q66HE2; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="Monocarboxylate transporter 13"
FT                   /id="PRO_0000287189"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        395..428
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  44993 MW;  7AC65745D23D3A79 CRC64;
     MVHRTEPPDG GWGWMVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA RVSWIASIGI
     AVQQFGSPIG SALSTKLGPR PVVMTGGILA ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
     TFTPTLACLS RYFSQRRSLA MGLALTGVGI SSFAFAPLFQ WLLNNYAWRG ALLLVSALSL
     HLVACGALLR PLSLTEDTAV GGPWAQITSL LCHGPFLRYT VALTLINTGY FIPYVHLVAH
     LQDLGWDPLP AAFLLSVAAI SDLVGRVASG WLGDAVPGPV ARLLMLWTTL TGVSLALFPV
     AQASTTLVVL AVAYGFTSGA LTPVAFSVIP ELVGTGRIYC GLGLVQMIES VGGLLGAPLS
     GYLRDVTGNY TASFVVAGAF LLAGSGVLIT LPHFFSCISL STSRPQDLVI EAPDTKIPLP
     KEEGLGEN
 
 
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