MOT14_HUMAN
ID MOT14_HUMAN Reviewed; 510 AA.
AC Q7RTX9; A8KA08; Q53R92; Q96NI7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Monocarboxylate transporter 14;
DE Short=MCT 14;
DE AltName: Full=Solute carrier family 16 member 14;
GN Name=SLC16A14; Synonyms=MCT14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Brain cortex, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION (ISOFORM 1).
RX PubMed=12739169; DOI=10.1007/s00424-003-1067-2;
RA Halestrap A.P., Meredith D.;
RT "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic
RT amino acid transporters and beyond.";
RL Pflugers Arch. 447:619-628(2004).
CC -!- FUNCTION: Proton-linked monocarboxylate transporter. May catalyze the
CC transport of monocarboxylates across the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7RTX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7RTX9-2; Sequence=VSP_025826;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR EMBL; AK055356; BAB70909.1; -; mRNA.
DR EMBL; AK292873; BAF85562.1; -; mRNA.
DR EMBL; AC093171; AAY24109.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70913.1; -; Genomic_DNA.
DR EMBL; BC065524; AAH65524.1; -; mRNA.
DR EMBL; BN000146; CAD80157.1; -; mRNA.
DR CCDS; CCDS2473.1; -. [Q7RTX9-1]
DR RefSeq; NP_689740.2; NM_152527.4. [Q7RTX9-1]
DR RefSeq; XP_011509053.1; XM_011510751.2. [Q7RTX9-1]
DR RefSeq; XP_016858969.1; XM_017003480.1. [Q7RTX9-1]
DR AlphaFoldDB; Q7RTX9; -.
DR SMR; Q7RTX9; -.
DR BioGRID; 127380; 12.
DR IntAct; Q7RTX9; 2.
DR STRING; 9606.ENSP00000295190; -.
DR TCDB; 2.A.1.13.12; the major facilitator superfamily (mfs).
DR iPTMnet; Q7RTX9; -.
DR PhosphoSitePlus; Q7RTX9; -.
DR BioMuta; SLC16A14; -.
DR DMDM; 74738645; -.
DR MassIVE; Q7RTX9; -.
DR PaxDb; Q7RTX9; -.
DR PeptideAtlas; Q7RTX9; -.
DR PRIDE; Q7RTX9; -.
DR Antibodypedia; 50076; 80 antibodies from 19 providers.
DR DNASU; 151473; -.
DR Ensembl; ENST00000295190.9; ENSP00000295190.4; ENSG00000163053.11. [Q7RTX9-1]
DR GeneID; 151473; -.
DR KEGG; hsa:151473; -.
DR MANE-Select; ENST00000295190.9; ENSP00000295190.4; NM_152527.5; NP_689740.2.
DR UCSC; uc002vqd.2; human. [Q7RTX9-1]
DR CTD; 151473; -.
DR GeneCards; SLC16A14; -.
DR HGNC; HGNC:26417; SLC16A14.
DR HPA; ENSG00000163053; Tissue enhanced (salivary).
DR neXtProt; NX_Q7RTX9; -.
DR OpenTargets; ENSG00000163053; -.
DR PharmGKB; PA134983567; -.
DR VEuPathDB; HostDB:ENSG00000163053; -.
DR eggNOG; KOG2504; Eukaryota.
DR GeneTree; ENSGT00940000160895; -.
DR HOGENOM; CLU_001265_59_1_1; -.
DR InParanoid; Q7RTX9; -.
DR OMA; CSEYGWR; -.
DR OrthoDB; 916876at2759; -.
DR PhylomeDB; Q7RTX9; -.
DR TreeFam; TF313792; -.
DR PathwayCommons; Q7RTX9; -.
DR SignaLink; Q7RTX9; -.
DR BioGRID-ORCS; 151473; 13 hits in 1066 CRISPR screens.
DR ChiTaRS; SLC16A14; human.
DR GenomeRNAi; 151473; -.
DR Pharos; Q7RTX9; Tbio.
DR PRO; PR:Q7RTX9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q7RTX9; protein.
DR Bgee; ENSG00000163053; Expressed in pigmented layer of retina and 182 other tissues.
DR ExpressionAtlas; Q7RTX9; baseline and differential.
DR Genevisible; Q7RTX9; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..510
FT /note="Monocarboxylate transporter 14"
FT /id="PRO_0000288923"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 495..510
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 214..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_025826"
FT CONFLICT 209
FT /note="M -> T (in Ref. 1; BAB70909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 56254 MW; 5510E3E9ED63C280 CRC64;
MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS QMALGVLNVE
WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR QTAIIGGLVN SLGWVLSAYA
ANVHYLFITF GVAAGLGSGM AYLPAVVMVG RYFQKRRALA QGLSTTGTGF GTFLMTVLLK
YLCAEYGWRN AMLIQGAVSL NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST
GQQGRTEEKD GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW
YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN DVFPLTSIIA
IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP LMHTYAGLAV ICALIGFSSG
YFSLMPVVTE DLVGIEHLAN AYGIIICANG ISALLGPPFA GWIYDITQKY DFSFYICGLL
YMIGILFLLI QPCIRIIEQS RRKYMDGAHV
